Recent advances in cyclization reactions of unsaturated oxime esters (ethers): synthesis of versatile functionalized nitrogen-containing scaffolds

Abstract

Cyclization/functionalization of unsaturated oxime esters (ethers) is a powerful strategy for the synthesis of versatile functionalized nitrogen-containing scaffolds, which are valuable structural motifs in numerous bioactive molecules. This review provides an overview of the recent advances in cascade cyclization of unsaturated oxime esters (ethers) with different functional group reagents. Typical examples are listed and mechanistic aspects are discussed in detail. Moreover, the remaining challenges and future perspectives are presented at the end.