Photoredox-catalyzed dicarbofunctionalization of styrenes with amines and CO2: a convenient access to γ-amino acids

Bo Zhang; Yaping Yi; Zhong-Qian Wu; Chao Chen; Chanjuan Xi

doi:10.1039/D0GC02254C

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Photoredox-catalyzed dicarbofunctionalization of styrenes with amines and CO₂: a convenient access to γ-amino acids†

Bo Zhang,^a Yaping Yi,^a Zhong-Qian Wu,^a Chao Chen

*^a and Chanjuan Xi

*^ab

Author affiliations

* Corresponding authors

^a MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Department of Chemistry, Tsinghua University, Beijing 100084, China
E-mail: cjxi@tsinghua.edu.cn, chenchao01@mails.tsinghua.edu.cn

^b State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China

Abstract

A visible-light-promoted carbocarboxylation of styrenes using CO₂ and amines is reported. The reaction is catalyzed by a photoredox catalyst and is compatible with a variety of amines and styrenes. This method affords highly functionalized γ-amino acids in good yields with high regioselectivity.

This article is part of the themed collections: CO2 Utilisation and 2020 Green Chemistry Hot Articles

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Article information

DOI: https://doi.org/10.1039/D0GC02254C
Article type: Communication
Submitted: 02 Jul 2020
Accepted: 18 Aug 2020
First published: 18 Aug 2020

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Green Chem., 2020,22, 5961-5965

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Photoredox-catalyzed dicarbofunctionalization of styrenes with amines and CO₂: a convenient access to γ-amino acids

B. Zhang, Y. Yi, Z. Wu, C. Chen and C. Xi, Green Chem., 2020, 22, 5961 DOI: 10.1039/D0GC02254C

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