Issue 73, 2018
From the journal:

Chemical Communications

Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite†

Jia Hao Pang,a   Atsushi Kagaa  and  Shunsuke Chiba ORCID logo *a  

* Corresponding authors

a Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore
E-mail: shunsuke@ntu.edu.sg

Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

Graphical abstract: Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CC05979A
Article type
Communication
Submitted
24 Jul 2018
Accepted
15 Aug 2018
First published
16 Aug 2018

Chem. Commun., 2018,54, 10324-10327

Permissions

Request permissions

Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

J. H. Pang, A. Kaga and S. Chiba, Chem. Commun., 2018, 54, 10324 DOI: 10.1039/C8CC05979A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements