Issue 59, 2018
From the journal:

Chemical Communications

NaI-mediated divergent synthesis of isatins and isoindigoes: a new protocol enabled by an oxidation relay strategy†

Hong-hua Zhang,‡a   Yong-qiang Wang,‡a   Long-tao Huang,a   Long-qing Zhu,a   Yi-yue Feng,a   Ying-mei Lu,a   Quan-yi Zhao,a   Xue-qiang Wang ORCID logo *b  and  Zhen Wang ORCID logo *a  

* Corresponding authors

a School of Pharmacy, Lanzhou University, West Donggang Road. No. 199, Lanzhou 730000, China
E-mail: zhenw@lzu.edu.cn

b State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, 2 Lushan Nan Road, Changsha, Hunan 410082, China
E-mail: wangxq@hnu,edu.cn

Abstract

A new approach for the synthesis of isatins and isoindigoes by an inexpensive and environmentally friendly NaI-mediated transformation is disclosed. The selectivity could be switched by simply varying the solvent, and isatins (using THF) and isoindigoes (using DMSO) could be obtained in moderate to excellent yields.

Graphical abstract: NaI-mediated divergent synthesis of isatins and isoindigoes: a new protocol enabled by an oxidation relay strategy

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Article information

DOI
https://doi.org/10.1039/C8CC04471F
Article type
Communication
Submitted
05 Jun 2018
Accepted
03 Jul 2018
First published
04 Jul 2018

Chem. Commun., 2018,54, 8265-8268

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NaI-mediated divergent synthesis of isatins and isoindigoes: a new protocol enabled by an oxidation relay strategy

H. Zhang, Y. Wang, L. Huang, L. Zhu, Y. Feng, Y. Lu, Q. Zhao, X. Wang and Z. Wang, Chem. Commun., 2018, 54, 8265 DOI: 10.1039/C8CC04471F

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