New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications

Vincenzo Taresco; Jiraphong Suksiriworapong; Ioanna D. Styliari; Richard H. Argent; Sadie M. E. Swainson; Jonathan Booth; Eleanor Turpin; Charles A. Laughton; Jonathan C. Burley; Cameron Alexander; Martin C. Garnett

doi:10.1039/C6RA21464A

New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications†

Vincenzo Taresco,^a Jiraphong Suksiriworapong,^b Ioanna D. Styliari,^a Richard H. Argent,^a Sadie M. E. Swainson,^a Jonathan Booth,^c Eleanor Turpin,^a Charles A. Laughton,^a Jonathan C. Burley,^a Cameron Alexander

^a and Martin C. Garnett

*^a

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* Corresponding authors

^a University of Nottingham, School of Pharmacy, University Park, Nottingham, UK
E-mail: Martin.Garnett@nottingham.ac.uk

^b Mahidol University, Department of Pharmacy, Faculty of Pharmacy, Bangkok, Thailand

^c AstraZeneca, Macclesfield, UK

Abstract

A novel class of biodegradable polyesters has been generated by coupling poly(glycerol adipate) with N-acyl aromatic amino acids. This new set of polymers from this highly versatile polymeric platform may offer unprecedented new opportunities to produce biodegradable and biocompatible polymers with tailorable physical–chemical properties.

This article is part of the themed collection: Contributions from the chemical industry

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New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications†

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New N-acyl amino acid-functionalized biodegradable polyesters for pharmaceutical and biomedical applications

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