Issue 40, 2012
From the journal:

Journal of Materials Chemistry

Polymer–gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(iii) complexes†

Mariana Beija,a   Yang Li,a   Hien T. Duong,a   Sophie Laurent,b   Luce Vander Elst,b   Robert N. Muller,bc   Andrew B. Lowe,*d   Thomas P. Davis*a  and  Cyrille Boyer*a  

* Corresponding authors

a Australian Centre for NanoMedicine (ACN), School of Chemical Engineering, The University of New South Wales, Sydney, NSW 2052, Australia
E-mail: t.davis@unsw.edu.au, cboyer@unsw.edu.au

b NMR and Molecular Imaging Laboratory, Department of General, Organic and Biomedical Chemistry, University of Mons, 7000 Mons, Belgium

c Center for Microscopy and Molecular Imaging, Rue Adrienne Bolland 8, 6041 Charleroi, Belgium

d Centre for Advanced Macromolecular Design (CAMD), The University of New South Wales, Sydney, NSW 2052, Australia
E-mail: a.lowe@unsw.edu.au

Abstract

We present a new synthetic strategy to produce Gd(III)-decorated gold nanoparticles (AuNPs) for potential use as bimodal contrast agents (CA) for computed X-ray tomography (CT) and magnetic resonance imaging (MRI). The hybrid AuNPs exhibit high molar relaxivities (>12 000 mM−1 s−1 per particle), indicative of highly efficient CT/MRI CAs.

Graphical abstract: Polymer–gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(iii) complexes

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Article information

DOI
https://doi.org/10.1039/C2JM34999J
Article type
Communication
Submitted
27 Jul 2012
Accepted
30 Aug 2012
First published
14 Sep 2012

J. Mater. Chem., 2012,22, 21382-21386

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Polymer–gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes

M. Beija, Y. Li, H. T. Duong, S. Laurent, L. V. Elst, R. N. Muller, A. B. Lowe, T. P. Davis and C. Boyer, J. Mater. Chem., 2012, 22, 21382 DOI: 10.1039/C2JM34999J

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