Visible light photocatalytic reductive hydroalkylation and deuterium alkylation to access α-silylated bicyclo[1.1.1]pentanes
Abstract
As pharmacophoric elements, both bicyclo[1.1.1]pentanes (BCPs) and silyl substituents have found widespread applications in drug discovery. However, systematic synthetic methods for α-silylated BCPs remain limited. Herein, we report a photocatalytic hydro/deutero-alkylation of propellane that enables the synthesis of α-silylated BCPs, showcasing broad substituent compatibility.
- This article is part of the themed collection: New Talent 2025

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