* Corresponding authors

^a Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, University of South China, Hengyang, Hunan, China
E-mail: guozifen76@163.com

^b CAS Key Laboratory of Receptor Research, CAS Center for Excellence in Molecular Cell Science, Center for Biotherapeutics Discovery Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Pudong, Shanghai 201203, P. R. China
E-mail: tangfeng2013@simm.ac.cn

^c School of Chinese Materia Medica, Nanjing University of Chinese Medicine, Nanjing, China

^d University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, P. R. China

^e School of Pharmaceutical Science and Technology, Hangzhou, Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, P. R. China
E-mail: huangwei@simm.ac.cn