Issue 16, 2021
From the journal:

RSC Advances

Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles†

Tung T. Nguyen, ORCID logo *ab   Lam V. Le,ab   Hai H. Pham,ab   Dung H. Nguyen,ab   Nam T. S. Phan, ORCID logo ab   Ha V. Leab  and  Anh N. Q. Phan*ab  

* Corresponding authors

a Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam
E-mail: tungtn@hcmut.edu.vn, pnqanh@hcmut.edu.vn

b Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

Abstract

We report a method for directed ortho-arylation of N-aryl pyrazoles with arylboronic acids. Reactions proceeded in the presence of a Co(hfacac)2 catalyst, CeSO4 oxidant, and HFIP solvent. Functionalities such as nitro, ester, bromo, and ketone groups were compatible with the reaction conditions. Using heterocycles including thiophene and carbazole was also feasible.

Graphical abstract: Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles

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Article information

DOI
https://doi.org/10.1039/D1RA00975C
Article type
Paper
Submitted
05 Feb 2021
Accepted
24 Feb 2021
First published
01 Mar 2021
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2021,11, 9349-9352

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Cobalt-catalyzed, directed arylation of C–H bonds in N-aryl pyrazoles

T. T. Nguyen, L. V. Le, H. H. Pham, D. H. Nguyen, N. T. S. Phan, H. V. Le and A. N. Q. Phan, RSC Adv., 2021, 11, 9349 DOI: 10.1039/D1RA00975C

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