Issue 66, 2020
From the journal:

RSC Advances

Homo-condensation of acetophenones toward imidazothiones†

Phuc Hoang Pham, ORCID logo ‡ab   Phuc Thai Thien Nguyen, ORCID logo ‡ab   Thuy Thu Bui,ab   Hien Nhat Tra, ORCID logo ab   Tung Thanh Nguyen ORCID logo *ab  and  Nam Thanh Son Phan ORCID logo *ab  

* Corresponding authors

a Faculty of Chemical Engineering, Ho Chi Minh City University of Technology (HCMUT), 268 Ly Thuong Kiet, District 10, Ho Chi Minh City, Vietnam
E-mail: tungtn@hcmut.edu.vn, ptsnam@hcmut.edu.vn

b Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Vietnam

Abstract

Direct synthesis of imidazothiones from simple, commercial substrates is not known. We report a method for the condensation of acetophenones, elemental sulfur, and ammonium acetate as a nitrogen source to obtain the hitherto challenging five-membered heterocycles. Functionalities such as halogen, trifluoromethyl, cyano, methylthio, and heteroaryl groups were well tolerated.

Graphical abstract: Homo-condensation of acetophenones toward imidazothiones

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DOI
https://doi.org/10.1039/D0RA03047C
Article type
Paper
Submitted
04 Apr 2020
Accepted
30 Oct 2020
First published
04 Nov 2020
This article is Open Access
Creative Commons BY-NC license

RSC Adv., 2020,10, 40225-40228

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Homo-condensation of acetophenones toward imidazothiones

P. H. Pham, P. T. Thien Nguyen, T. T. Bui, H. N. Tra, T. T. Nguyen and N. T. Son Phan, RSC Adv., 2020, 10, 40225 DOI: 10.1039/D0RA03047C

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