Rhodium(iii)-catalyzed oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols†
Abstract
An efficient Rh(III)-catalyzed C–H oxidative alkylation of N-aryl-7-azaindoles with cyclopropanols by merging tandem C–H and C–C cleavage was developed. This transformation features mild reaction conditions, high regioselectivity, and excellent functional group compatibility. The resulting β-aryl ketone derivatives can be readily transformed into 7-azaindole-containing π-extended polycyclic heteroarenes.
- This article is part of the themed collection: Synthetic methodology in OBC
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