A tumor-targeting probe based on a mitophagy process for live imaging

Lijuan Gui; Zhenwei Yuan; Habtamu Kassaye; Jinrong Zheng; Yuxin Yao; Fei Wang; Qing He; Yuanzhi Shen; Li Liang; Haiyan Chen

doi:10.1039/C8CC04246B

A tumor-targeting probe based on a mitophagy process for live imaging†

Lijuan Gui,‡^a Zhenwei Yuan,‡^a Habtamu Kassaye,^a Jinrong Zheng,^a Yuxin Yao,^a Fei Wang,^a Qing He,^a Yuanzhi Shen,^a Li Liang^a and Haiyan Chen

*^a

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^a Department of Biomedical Engineering, School of Engineering, China Pharmaceutical University, 24 Tongjia Lane, Gulou District, Nanjing 210009, China
E-mail: chenhaiyan@cpu.edu.cn

Abstract

A glucosamine modified near-infrared cyanine dye CyT sensitive to pH was synthesized. Due to the different pH values of mitochondria and autolysosomes, the probe can simultaneously investigate mitochondria and autolysosomes in living cells. Moreover, due to the introduction of glucosamine groups, this fluorescent probe can be applied for tumor targeted imaging.

Chemical Communications

A tumor-targeting probe based on a mitophagy process for live imaging†

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A tumor-targeting probe based on a mitophagy process for live imaging

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