Yann Fichou, Michael Vigers, Andrew K. Goring, Neil A. Eschmann and Songi Han
Chem. Commun., 2018,54, 4573-4576
DOI:
10.1039/C8CC01355A,
Communication
Alzheimer's disease (AD) is characterized by the presence of tau filaments in the brain whose structure was recently solved. The formation of AD filaments is routinely modeled in vitro by mixing tau with heparin. This study shows that heparin-induced tau filaments are markedly different from the AD filaments and are highly heterogeneous.