Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

Srinivasulu Aitipamula; Pui Shan Chow; Reginald B. H. Tan

doi:10.1039/C7CE01979C

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Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’†

Srinivasulu Aitipamula,

*^a Pui Shan Chow

^a and Reginald B. H. Tan

*^ab

Author affiliations

* Corresponding authors

^a Crystallization and Formulation Science, Institute of Chemical and Engineering Sciences, A*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore
E-mail: srinivasulu_aitipamula@ices.a-star.edu.sg

^b Department of Chemical & Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore
E-mail: reginald_tan@ices.a-star.edu.sg

Abstract

The inadvertent errors in the lattice energy calculations of the polymorphs reported in our previous article (CrystEngComm, 2009, 11, 1823–1827) were rectified. Form I (Refcode: QULLUF) was found to be the most thermodynamically stable polymorph by slurry experiments even though it has marginally higher lattice energy than the other two polymorphs.

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Article information

DOI: https://doi.org/10.1039/C7CE01979C
Article type: Letter
Submitted: 14 Nov 2017
Accepted: 13 Dec 2017
First published: 13 Dec 2017

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CrystEngComm, 2018,20, 373-374

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Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2018, 20, 373 DOI: 10.1039/C7CE01979C

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Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’†

Abstract

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Supplementary files

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Reply to the ‘Comment on “Trimorphs of a pharmaceutical cocrystal involving two active pharmaceutical ingredients: potential relevance to combination drugs” by S. Aitipamula, P. S. Chow and R. B. H. Tan, CrystEngComm, 2009, 11, 1823’

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