Issue 11, 2017
From the journal:

Journal of Materials Chemistry B

Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells†

Cheng Wang,a   Shaoqing Chen,a   Qin Yu,a   Fuqiang Hua  and  Hong Yuan ORCID logo *a  

* Corresponding authors

a College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, China
E-mail: yuanhong70@zju.edu.cn

Abstract

The high aqueous instability of amorphous calcium carbonate (ACC), which will lead to a burst release of its payload, has generally been recognized as the major obstacle for its further application in nanomedicine. Herein, a locking/unlocking strategy was applied to employ the instability of ACC to realize burst drug release within cancer cells.

Graphical abstract: Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells

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Article information

DOI
https://doi.org/10.1039/C6TB02826H
Article type
Communication
Submitted
28 Oct 2016
Accepted
13 Feb 2017
First published
14 Feb 2017

J. Mater. Chem. B, 2017,5, 2068-2073

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Taking advantage of the disadvantage: employing the high aqueous instability of amorphous calcium carbonate to realize burst drug release within cancer cells

C. Wang, S. Chen, Q. Yu, F. Hu and H. Yuan, J. Mater. Chem. B, 2017, 5, 2068 DOI: 10.1039/C6TB02826H

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