Issue 32, 2016

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Abstract

We have discovered and characterised a fluorinating enzyme from marine-derived Streptomyces xinghaiensis. It is able to install a fluorine atom into S-adenosyl-L-methionine (SAM) to form 5′-fluorodeoxy adenosine. To our knowledge, this is the first ever fluorinase unveiled from a marine source. It is ‘the most efficient’ fluorinase by far and, impressively, highly robust. Therefore it promises to be useful in different cases such as bio-transformation and synthetic biology.

Graphical abstract: Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
03 Jan 2016
Accepted
27 Feb 2016
First published
02 Mar 2016
This article is Open Access
Creative Commons BY license

RSC Adv., 2016,6, 27047-27051

Biological fluorination from the sea: discovery of a SAM-dependent nucleophilic fluorinating enzyme from the marine-derived bacterium Streptomyces xinghaiensis NRRL B24674

L. Ma, Y. Li, L. Meng, H. Deng, Y. Li, Q. Zhang and A. Diao, RSC Adv., 2016, 6, 27047 DOI: 10.1039/C6RA00100A

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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