AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging

Jun Wang; Yinglong Wu; Fang Zeng; Shuailing Huang; Shuizhu Wu

doi:10.1039/C6FD00118A

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AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging†

Jun Wang,‡^a Yinglong Wu,‡^a Fang Zeng,*^a Shuailing Huang^a and Shuizhu Wu*^a

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* Corresponding authors

^a College of Materials Science and Engineering, State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640, P. R. China
E-mail: mcfzeng@scut.edu.cn, shzhwu@scut.edu.cn
Fax: +86 20 22236363
Tel: +86 20 22236262

Abstract

Fluorophores with aggregation-induced emission (AIE) characteristics are attractive and versatile tools for both chemical sensing and biological imaging. Herein, we designed and synthesized a fluorescent light-up system CTPE-Tau with enhanced cellular uptake ability. The system possesses several advantages, such as a large Stokes shift, low cytotoxicity, and good photostability. Also, it has been successfully utilized to track esterase-activated release of taurine and to scavenge intracellular ROS, and shows great potential for trackable visualized therapy.

This article is part of the themed collection: Aggregation Induced Emission

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Associated articles

Biomedical applications of luminogens: general discussion

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Article information

DOI: https://doi.org/10.1039/C6FD00118A
Article type: Paper
Submitted: 06 May 2016
Accepted: 14 Jun 2016
First published: 14 Jun 2016

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Faraday Discuss., 2017,196, 335-350

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AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging

J. Wang, Y. Wu, F. Zeng, S. Huang and S. Wu, Faraday Discuss., 2017, 196, 335 DOI: 10.1039/C6FD00118A

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Faraday Discussions

AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging†

Abstract

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Supplementary files

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AIE fluorophore with enhanced cellular uptake for tracking esterase-activated release of taurine and ROS scavenging

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