Issue 96, 2016
From the journal:

Chemical Communications

Remote meta C–H bond functionalization of 2-phenethylsulphonic acid and 3-phenylpropanoic acid derivatives†

Atanu Modak,a   Anirban Mondal,a   Rahul Watile,a   Semanti Mukherjeea  and  Debabrata Maiti*a  

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
E-mail: dmaiti@chem.iitb.ac.in

Abstract

This discovery illustrates selective meta C–H bond activation from multiple non-equivalent C–H bonds present in medicinally relevant arylethanesulfonic acid and the 2-arylpropanoic acid moiety using weakly coordinating nitrile as a directing group. Transformation of the meta olefinated compounds to important organic molecules has been demonstrated. Efforts were made to obtain mechanistic detail of the meta C–H bond functionalization reaction.

Graphical abstract: Remote meta C–H bond functionalization of 2-phenethylsulphonic acid and 3-phenylpropanoic acid derivatives

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Article information

DOI
https://doi.org/10.1039/C6CC08302A
Article type
Communication
Submitted
14 Oct 2016
Accepted
07 Nov 2016
First published
07 Nov 2016

Chem. Commun., 2016,52, 13916-13919

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Remote meta C–H bond functionalization of 2-phenethylsulphonic acid and 3-phenylpropanoic acid derivatives

A. Modak, A. Mondal, R. Watile, S. Mukherjee and D. Maiti, Chem. Commun., 2016, 52, 13916 DOI: 10.1039/C6CC08302A

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