Decarboxylative Csp3–Csp3 coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols

Sasa Wang; Xinzheng Chen; Qiaoqiao Ao; Huifei Wang; Hongbin Zhai

doi:10.1039/C6CC03835B

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Decarboxylative C_sp³–C_sp³ coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols†

Sasa Wang,^a Xinzheng Chen,^a Qiaoqiao Ao,^b Huifei Wang*^a and Hongbin Zhai*^acd

Author affiliations

* Corresponding authors

^a Guangdong Provincial Key Laboratory of Nano-Micro Materials Research, Key Laboratory of Chemical Genomics, Shenzhen Graduate School of Peking University, Shenzhen 518055, China
E-mail: wanghf@pkusz.edu.cn, zhaihb@pkusz.edu.cn

^b The State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China

^c College of Science, Northwest A&F University, Xi'an 712100, China

^d Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, China

Abstract

A new decarboxylative C_sp³–C_sp³ coupling approach for the benzylation of ketone enolates has been developed. A variety of raspberry ketone derivatives were conveniently synthesized in good to excellent yields under mild conditions. A crossover reaction shed light on the mechanism of this tandem reaction.

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Correction: Decarboxylative Csp3–Csp3 coupling for benzylation of unstable keton…

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Article information

DOI: https://doi.org/10.1039/C6CC03835B
Article type: Communication
Submitted: 07 May 2016
Accepted: 27 Jun 2016
First published: 27 Jun 2016

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Chem. Commun., 2016,52, 9454-9457

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Decarboxylative C_sp³–C_sp³ coupling for benzylation of unstable ketone enolates: synthesis of p-(acylethyl)phenols

S. Wang, X. Chen, Q. Ao, H. Wang and H. Zhai, Chem. Commun., 2016, 52, 9454 DOI: 10.1039/C6CC03835B

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