Issue 99, 2015

Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

Abstract

Self-assembled cholesterol–asplatin-incorporated nanoparticles (SCANs) were prepared for oral delivery of a Pt(IV) prodrug. SCANs exhibit high gastrointestinal stability, sustained drug release and enhanced cell uptake. The oral bioavailability of SCANs was 4.32-fold higher than that of free Pt(IV) prodrugs. The oral administration of SCANs efficaciously inhibits tumor growth with negligible toxicity.

Graphical abstract: Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

Associated articles

Supplementary files

Article information

Article type
Communication
Submitted
18 Sep 2015
Accepted
09 Oct 2015
First published
12 Oct 2015

Chem. Commun., 2015,51, 17536-17539

Oral delivery of a platinum anticancer drug using lipid assisted polymeric nanoparticles

Q. Cheng, H. Shi, H. Huang, Z. Cao, J. Wang and Y. Liu, Chem. Commun., 2015, 51, 17536 DOI: 10.1039/C5CC07853A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements