Issue 64, 2015
From the journal:

Chemical Communications

A ring to rule them all: a cyclic ketene acetal comonomer controls the nitroxide-mediated polymerization of methacrylates and confers tunable degradability†

Vianney Delplace,a   Elise Guégain,a   Simon Harrisson,b   Didier Gigmes,c   Yohann Guillaneufc  and  Julien Nicolas*a  

* Corresponding authors

a Institut Galien Paris-Sud, Université Paris-Sud, UMR CNRS 8612, Faculté de Pharmacie, 5 rue Jean-Baptiste Clément, F-92296 Châtenay-Malabry cedex, France
E-mail: julien.nicolas@u-psud.fr
Web: http://www.twitter.com/julnicolas

b Université de Toulouse, CNRS, Laboratoire des Interactions Moléculaires et Réactivité Chimique et Photochimique UMR 5623, 118 route de Narbonne, F-31062 Toulouse, France

c Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire UMR 7273, Avenue Escadrille Normandie-Niemen, F-13397 Marseille cedex 20, France

Abstract

2-Methylene-4-phenyl-1,3-dioxolane (MPDL) was successfully used as a controlling comonomer in NMP with oligo(ethylene glycol) methyl ether methacrylate (MeOEGMA) to prepare well-defined and degradable PEG-based P(MeOEGMA-co-MPDL) copolymers. The level of ester group incorporation is controlled, leading to reductions in molecular weight of up to 95% on hydrolysis. Neither the polymer nor its degradation products displayed cytoxicity. The method was also successfully applied to methyl methacrylate.

Graphical abstract: A ring to rule them all: a cyclic ketene acetal comonomer controls the nitroxide-mediated polymerization of methacrylates and confers tunable degradability

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DOI
https://doi.org/10.1039/C5CC04610F
Article type
Communication
Submitted
04 Jun 2015
Accepted
06 Jul 2015
First published
14 Jul 2015
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2015,51, 12847-12850

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A ring to rule them all: a cyclic ketene acetal comonomer controls the nitroxide-mediated polymerization of methacrylates and confers tunable degradability

V. Delplace, E. Guégain, S. Harrisson, D. Gigmes, Y. Guillaneuf and J. Nicolas, Chem. Commun., 2015, 51, 12847 DOI: 10.1039/C5CC04610F

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