Issue 24, 2014
From the journal:

Dalton Transactions

Ni2+ chemistry in pathogens – a possible target for eradication

Magdalena Rowinska-Zyrek,*a   Jolanta Zakrzewska-Czerwinska,bc   Anna Zawilak-Pawlikc  and  Henryk Kozlowskia  

* Corresponding authors

a Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, 50-383 Wroclaw, Poland
E-mail: magdalena.rowinska-zyrek@chem.uni.wroc.pl

b Faculty of Biotechnology, University of Wroclaw, F. Joliot-Curie 14A, 50-383 Wroclaw, Poland
E-mail: jolanta.zakrzewska@uni.wroc.pl

c Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Department of Microbiology, Weigla 12, 53-114 Wrocław, Poland
E-mail: zawilak@iitd.pan.wroc.pl

Abstract

The survival of all urease and/or hydrogenase containing pathogens depends on the proper homeostasis of nickel. In the scope of this perspectives paper, details of Ni2+ metabolism of Helicobacter pylori, a widespread stomach-ulcer causing bacterium, are described. Nickel binding proteins and thermodynamics of such metal complexes are discussed in detail and special focus is given to potential nickel binding sequences in this metal's chaperones and regulators. A list of potential Ni2+ binding sites in various pathogens is presented, which points out numerous examples of nickel interactions that still need to be understood.

Graphical abstract: Ni2+ chemistry in pathogens – a possible target for eradication

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Article information

DOI
https://doi.org/10.1039/C4DT00421C
Article type
Perspective
Submitted
09 Feb 2014
Accepted
04 Apr 2014
First published
07 Apr 2014

Dalton Trans., 2014,43, 8976-8989

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Ni2+ chemistry in pathogens – a possible target for eradication

M. Rowinska-Zyrek, J. Zakrzewska-Czerwinska, A. Zawilak-Pawlik and H. Kozlowski, Dalton Trans., 2014, 43, 8976 DOI: 10.1039/C4DT00421C

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