Issue 32, 2015
From the journal:

Chemical Communications

Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey

Robert Li-Yuan Bao,a   Rong Zhaoa  and  Lei Shi*a  

* Corresponding authors

a Institute of Organic Chemistry, The Academy of Fundamental and Interdisciplinary Science, Harbin Institute of Technology, Harbin 150080, P. R. China
E-mail: lshi@hit.edu.cn
Tel: +86-451-86403860

Abstract

Over the past decade, the effectiveness of i-PrMgCl·LiCl has been constantly highlighted by a number of research groups. Its enhanced nucleophilicity brings prosperity to highly functionalized Grignard reagents, other useful bimetallic (alkali-metal) agents and nucleophilic alkylation products under mild reaction conditions. In this feature article, a comprehensive, systematical and in-depth overview of i-PrMgCl·LiCl is provided in a multidisciplinary idea. It involves the structural and kinetic perspectives of i-PrMgCl·LiCl as well as its unique reactivity and selectivity, with knowledge of the former helping to rationalize trends of the later.

Graphical abstract: Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey

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Article information

DOI
https://doi.org/10.1039/C4CC10194D
Article type
Feature Article
Submitted
21 Dec 2014
Accepted
19 Feb 2015
First published
19 Feb 2015

Chem. Commun., 2015,51, 6884-6900

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Progress and developments in the turbo Grignard reagent i-PrMgCl·LiCl: a ten-year journey

R. Li-Yuan Bao, R. Zhao and L. Shi, Chem. Commun., 2015, 51, 6884 DOI: 10.1039/C4CC10194D

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