A concise synthesis of an alkylation subunit of the duocarmycins is achieved via a C–H-activation approach. The ethyl ester analogue of duocarmycin SA can be made in eleven linear steps from a commercially available precursor.
The natural product yatakemycin (YTM) is a potent antimicrobial DNA damaging agent. YtkR4 and YtkR5 are deoxyribonucleases that provide resistance to YTM toxicity by removing the a basic site produced by YtkR2 cleavage of a YTM-adenosine lesion.
This review discusses the diverse enzymatic pathways in the biosynthesis of cyclopropane, a unique structural motif with important biochemical properties.
Natural products (NPs) have long been foundational in medicine, from ancient herbal remedies to the discovery of transformative drugs like morphine and quinine.
In this review glycosidase activated prodrugs that target cancer cells are discussed.