This review summarizes the recent advances in the synthesis and application of furoxan molecules, with special attention to the synthetic strategy of the post-ring introduction of substituents (PRIS).
A novel bis-(triazolyl)-furoxan structure has been developed to balance detonation and sensitivity, attributed to its graphene-like layered stacking arrangement of crystals.
A novel hybrid integrating piplartine with a furoxan moiety exhibited a sub-micromolar IC50 and extraordinary selectivity for PC3 cells, which was associated with its capacity to release NO, generate ROS, induce DNA damage, and trigger apoptosis.
OTF simultaneously meets the high requirements of high density, high detonation velocity, excellent decomposition temperature, and low impact sensitivity, which is rarely reported in the field of energetic materials.
A series of new high-nitrogen energetic salts comprising linearly linked 1,2,4-triazole, furoxan and N-hydroxytetrazole scaffolds were synthesized.