Colchicine–cinnamic acid hybrid B7 exhibits potent antitumor activity in vitro and in vivo.
Sulfonamide derivatives are potential tubulin binding agents which specifically binds to the colchicine site of microtubule. Sulfonamide derivatives potentially disrupt the polymerization process of tubulin network and induce the cancer cell death.
Sulfonamide-functionalized PCAs showed potent tubulin inhibition, strong anticancer selectivity, low hemolytic activity, and favorable physicochemical properties. Compounds 3 and 5 emerged as lead colchicine-site tubulin inhibitors.
Fluorescent tubulin-targeting agents: from probe development to applications and strategies for next-generation ligands.
A series of quinoline derivatives was designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site.