We have developed a novel TfOH-catalyzed regioselective O-alkylation of 2-pyridones with diazo compounds in high regioselectivity. This protocol is characterized by mild reaction conditions, metal-free, and simplicity.
A thianthrene (TT)/TfOH-catalyzed electrophilic halogenation has been developed, enabling broad substrate applicability and diverse halogenation types via the generation of a TT-based halogenated thianthrenium salt.
An unprecedented TfOH-catalyzed transfer hydrogenation reaction has been developed using 1-tetralone as a novel dihydrogen source.
This method provides sulfur-containing heterocyclic compounds from propargyl compounds, which had not been achieved even with transition metal catalysts.
A highly efficient and chemoselective approach has been developed for the O- and S- trifluoroethylation of oxindoles, isoindolines, and thio-oxindoles utilizing Brønsted acid catalysis under greener protocol.