Cancer is the second most high-morbidity disease throughout the world.
Asymmetric synthesis of functionalized nitrogen-containing compounds via the direct condensation of amines with carbonyls, focusing on the desymmetrization or dynamic kinetic resolution, the de novo cycloaromatization and the Heyns rearrangement.
A rare example of hydrolytic instability of the C–F bond: the trifluoromethyl group in 2,2,2-trifluoroethylphosphinic acids undergoes alkaline hydrolysis and forms carboxymethylphosphinate and fluoride.
This review highlights the recent advances in multi-component reactions for synthesizing heterocyclic compounds via green approaches including photoredox catalysis, electrochemical activation, catalyst-free methods and use of water as sole solvent.
The use of manganese oxide (MnOx)-based catalysts has gained significant recognition as a promising solution for the sustainable synthesis of value-added chemicals.