A novel strategy for the selective synthesis of (E)-vinyl sulfone derivatives from p-tosylmethyl isocyanide (TosMIC) and ortho-substituted benzaldehydes has been established.
Herein a rapid continuous flow method for the conversion of aryl ketones to nitriles is presented, which features advantages such as improved safety, substrate scope and scalability.
A base-promoted approach has been devised for the synthesis of pyrrole derivatives via a [3 + 2] cycloaddition reaction of propiolonitriles with isocyanides within 10–90 min.
Herein, we report highly efficient and base-promoted approaches for the diversity-oriented synthesis of 2,5- and 4,5-disubstituted thiazoles using alkyl 2-(methylthio)-2-thioxoacetates as synthetic precursors.
Over the past decade, there has been exponential growth in the vicinal iodosulfonylation of alkynes using sulfonyl and iodide reactants. This review highlights the recent developments of β-iodovinyl sulfones and their applications in organic synthesis.