Chiral diphenylprolinol silyl ethers have been successfully identified for the enantioselective allenation reaction of terminal alkynes and 2-alkynals, delivering a diverse set of chiral allenynes with high efficiency.
Highly substituted trans-hydrindanes were synthesized by the three-component coupling reactions of 1,3-diethyl 2-(2-oxopropylidene)propanedioate and two different α,β-unsaturated aldehydes catalyzed by diphenylprolinol silyl ether.
In this review, we provide an overview of alkaloid syntheses reported since 2017, categorized by scaffold, with a focus on key steps involving asymmetric reactions catalyzed by secondary amine organocatalysts.
An efficient synthesis of kainoid member, (+)-allokainic acid has been designed via diphenylprolinol catalyzed organocatalytic cross-aldol reaction.
Herein, we describe an efficient strategy for an asymmetric one-pot methodology for the synthesis of N-phenyl thioether-tethered tetrasubstituted chiral 4,5-dihydropyrrole-3-carbaldehydes utilizing chiral amine as a organocatalysts.