This review discusses the significant advances in the current status and latest synthesis techniques for N-substituted 3-acetyl-4-hydroxyquinolinones.
A green, one-pot sequential synthesis of functionalized quinolinones from benzhydrol is reported. This method features mild reaction conditions, high atom economy, scalability, and excellent yields. The photophysical properties were also explored.
Several fused/binary pyrazole quinolinone hybrids are synthesized via tandem reactions and their insecticidal efficacy against S. littoralis and A. gossypii are evaluated.
The advances in the Povarov reactions under visible-light conditions are highlighted, offering helpful guidance for selecting suitable synthetic protocols.
A chiral phosphoric acid-catalyzed Paal–Knorr reaction was achieved for constructing axially chiral pyrrolyl(aza)quinolinones with ‘6–5’-membered rings as a new family member of N–N atropisomers.