An ion-pair as a superacidic precatalyst for the synthesis of indole alkaloids: a novel entry into the Fischer indole synthesis

Abstract

The first ion-pair-catalysed Fischer indole synthesis is disclosed, powered by the superacidic [Ph₃C]⁺[B(C₆F₅)₄]⁻ system as the pre-catalyst. The method introduces a powerful tool for the synthesis of indole alkaloids with exceptional efficiency.

One-pot cobalt-catalyzed ring-opening of diaziridines for bismuth-promoted Fischer indole synthesis

Abstract

The cobalt-catalyzed tandem process enabling Fischer indole synthesis using stable diaziridine was developed. This one-pot cascade protocol features operational simplicity and mild conditions, eliminating the need to handle hazardous hydrazine.

Total synthesis of haploscleridamine, villagorgin A and an approach towards lissoclin C

Abstract

Total syntheses of scalemic samples of the marine-derived indole alkaloids haploscleridamine and villagorgin A were accomplished from S-histidine relying on ring-closing metathesis reaction and a modified Fischer indole synthesis.

Correction: Bis-Fischer indole[3,2-b]carbazole modification of [10]cycloparaphenylenes: tuning optical properties through rigid substitution

Continuous flow synthesis of N,N-dimethyltryptamine (DMT) analogues with therapeutic potential

Abstract

Flow chemistry allows for the rapid and clean synthesis of therapeutically relevant tryptamines in good yields, including the large scale drug rizatriptan.