Stanislav A. Paveliev, Andrey Dvoretskiy, Oleg O. Segida, Igor B. Krylov and Alexander O. Terent’ev
Chem. Commun., 2025,61, 14426-14429
Abstract
Electrochemical synthesis of O-imido oximes from azides and N-hydroxyimides via N–O coupling of iminyl and N-oxyl radicals has been discovered.
Elizaveta I. Basanova, Ekaterina A. Kulikova, Nikolai I. Bormotov, Olga A. Serova, Larisa N. Shishkina, Alyona S. Ovchinnikova, Dmitry A. Odnoshevskiy, Oleg V. Pyankov, Alexander P. Agafonov, Olga I. Yarovaya, Sophia S. Borisevich, Margarita G. Ilyina, Dmitry S. Kolybalov, Sergey G. Arkhipov, Nikita E. Bogdanov, Marina A. Pavlova, Nariman F. Salakhutdinov, Valery P. Perevalov and Polina A. Nikitina
RSC Med. Chem., 2024,15, 3196-3211
Abstract
Newly synthesized 2-aryl-1-hydroxyimidazoles display promising antiviral activity against orthopoxviruses, including the variola virus.
Vladislav O. Golfarb-Abramov, Anastasia V. Kazennova, Elizaveta I. Basanova, Olga A. Serova, Nikolai I. Bormotov, Larisa N. Shishkina, Vyacheslav I. Krasnov, Dmitriy N. Polovyanenko, Ivan A. Moskalev, Alexey Yu. Fedorov, Sergey G. Arkhipov, Margarita G. Ilyina, Sophia S. Borisevich, Olga I. Yarovaya and Polina A. Nikitina
New J. Chem., 2025,49, 19699-19717
Abstract
Structural features (isomers, tautomers, conformers) of N-substituted 2-(2-arylethenyl)imidazoles were considered. Antiviral activity against orthopoxviruses was evaluated, with 1-methoxyimidazoles being the most promising compounds.
Marcin Bielinski, Lucy R. Henderson, Yuliana Yosaatmadja, Lonnie P. Swift, Hannah T. Baddock, Matthew J. Bowen, Jürgen Brem, Philip S. Jones, Stuart P. McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A. Newman, Peter J. McHugh and Christopher J. Schofield
Chem. Sci., 2024,15, 8227-8241
Abstract
SNM1 metallo-β-lactamase fold nucleases (human SNM1A–C) play roles in DNA damage repair and telomere maintenance. Screening and SAR studies lead to selective small molecules validating SNM1A as a cancer target.
Alexander S. Budnikov, Igor B. Krylov, Mikhail I. Shevchenko, Lyubov’ L. Sokova, Yan Liu, Bing Yu and Alexander O. Terent'ev
Org. Biomol. Chem., 2024,22, 8755-8763
Abstract
Ring-opening oxyimidation of cyclobutanols and cyclopropanols with the formation of ω-functionalized ketones via radical cross-recombination is reported.