This review highlights advances in one-pot multicomponent synthesis of naphthyridine derivatives, focusing on efficient, atom-economical methods, diverse scaffolds and mechanistic insights fostering innovation in organic synthesis.
Our attempts to access these heteroatom-containing aromatic hexacycles are reported, as well as their photophysical properties, and ability to inhibit the activity of PIM 1 and 2 protein kinases.
An exceptional discovery of intermolecular cascade annulation for dihydrobenzo[b][1,8]naphthyridines involving specific aniline fragment transfer between Michael addition and SNAr has been reported.
A new unsymmetrical dinucleating PNNN ligand is reported, the versatility of which is demonstrated by formation of heterobimetallic, homobimetallic and monometallic complexes.
Twenty-eight compounds, viz., 1,8-naphthyridine-3-carbonitrile (ANC and ANA) derivatives, were designed and synthesized through a molecular hybridization approach. The designed compounds were evaluated for anti-TB activity against Mtb H37Rv strain.