A hybrid hydrogel constructed using drug loaded mesoporous silica and multiple response copolymer as an intelligent dressing for wound healing of diabetic foot ulcers

Wenrui Zhang, Zun Yang, Mingzu Zhang, Jinlin He, Shenzhi Li, Xingwei Sun and Peihong Ni

J. Mater. Chem. B, 2023, 11, 4922
DOI: 10.1039/D3TB00395G

Construction of multifunctional wound dressings with their application in chronic wound treatment

Linyu Long, Wenqi Liu, Cheng Hu, Li Yang and Yunbing Wang

Biomater. Sci., 2022, 10, 4058
DOI: 10.1039/D2BM00620K

A bioinspired injectable antioxidant hydrogel for prevention of postoperative adhesion

Lei Yuan, Hongxiu Wei, ZhongJing Pan, Xiaobo Deng, Lin Yang, Yanchao Wang, Dan Lu, Zhen Li, Feng Luo, Jiehua Li and Hong Tan

J. Mater. Chem. B, 2024, 12, 6968
DOI: 10.1039/D4TB00805G

A peptide-based pH-sensitive antibacterial hydrogel for healing drug-resistant biofilm-infected diabetic wounds

Duoyang Fan, Ruyan Xie, Xiaohui Liu, Haohan Li, Ziheng Luo, Yanbing Li, Fei Chen and Wenbin Zeng

J. Mater. Chem. B, 2024, 12, 5525
DOI: 10.1039/D4TB00594E

Recombinant human collagen microneedle patches loaded with PRP for diabetic wound treatment

Xinyue Wang, Xinyue Zhang, Yihan Zhao, Xue Zhan, Chen Hu, Haihang Li, Xiaoju Fan, Jie Liang, Yafang Chen and Yujiang Fan

J. Mater. Chem. B, 2025, 13, 9607
DOI: 10.1039/D5TB00836K

Polyphenol-driven facile assembly of a nanosized acid fibroblast growth factor-containing coacervate accelerates the healing of diabetic wounds

Meng-Qi Tong, Cui-Tao Lu, Lan-Tian Huang, Jiao-Jiao Yang, Si-Ting Yang, Hang-Bo Chen, Peng-Peng Xue, Lan-Zi Luo, Qing Yao, He-Lin Xu and Ying-Zheng Zhao

Acta Biomaterialia, 2023, 157, 467
DOI: 10.1016/j.actbio.2022.11.054

Preparation and characterization of a novel humanized collagen III with repeated fragments of Gly300-Asp329

Lingying Yan, Yao Zhang, Yuxiang Zhang, Qiexin Chen, Luyao Zhang, Xiao Han, Yumo Yang, Chun Zhang, Yongdong Liu and Rong Yu

Protein Expression and Purification, 2024, 219, 106473
DOI: 10.1016/j.pep.2024.106473

Microenvironment‐Based Diabetic Foot Ulcer Nanomedicine

Fang Huang, Xiangyu Lu, Yan Yang, Yushan Yang, Yongyong Li, Le Kuai, Bin Li, Haiqing Dong and Jianlin Shi

Advanced Science, 2023, 10
DOI: 10.1002/advs.202203308

Progress of stimulus responsive nanosystems for targeting treatment of bacterial infectious diseases

Niuniu Yang, Mengyuan Sun, Huixin Wang, Danlei Hu, Aoxue Zhang, Suliman Khan, Zhen Chen, Dongmei Chen and Shuyu Xie

Advances in Colloid and Interface Science, 2024, 324, 103078
DOI: 10.1016/j.cis.2024.103078

Effect of atomization on the composition and structure of recombinant humanized collagen type III

Ningwen Cheng, Xinyue Zhang, Jian Wang, Danfeng Li, Ling Li, Huan Hu and Tingli Qu

Journal of Applied Biomaterials & Functional Materials, 2024, 22
DOI: 10.1177/22808000241261904

Nucleoside-stabilized stimuli-responsive lipoic acid supramolecular hydrogel: An efficacious antioxidant and antibacterial platform for chronic diabetic wound repair

Chunyue Zhao, Tong Wu, Enchang Liu, Fangzheng Zhao, Qiqi Han, Zhen Wang, Rijie Wang, Tingbin Zhang and Jinfeng Xing

Acta Biomaterialia, 2026, 212, 281
DOI: 10.1016/j.actbio.2026.01.007

Biomimetic Strategies for Nutraceutical Delivery: Advances in Bionanomedicine for Enhanced Nutritional Health

Vicente Javier Clemente-Suárez, Alvaro Bustamante-Sanchez, Alejandro Rubio-Zarapuz, Alexandra Martín-Rodríguez, José Francisco Tornero-Aguilera and Ana Isabel Beltrán-Velasco

Biomimetics, 2025, 10, 426
DOI: 10.3390/biomimetics10070426

Hydrogel composite nanomaterials for diabetic wound treatment

Nuonan Li, Xianjun Luo, Hongwen Zhu, Guowang Shen, Meifang Li, Chunxia Zhou, Ning Liang, Puhua Zhang and Xiaoyong Zhu

Colloids and Surfaces B: Biointerfaces, 2026, 260, 115392
DOI: 10.1016/j.colsurfb.2025.115392

Rational Design of Multifunctional Hydrogels for Wound Repair

Juan Cao, Bo Wu, Ping Yuan, Yeqi Liu and Cheng Hu

JFB, 2023, 14, 553
DOI: 10.3390/jfb14110553

The Importance of Sex-Based Comparisons in Preclinical Nanomedicine and Regenerative Chronic Wound Therapies

Negar Mahmoudi, Mohsin Hassan Saeed, Lars Peereboom, Xinyue Liu, David R. Nisbet and Morteza Mahmoudi

ACS Biomater. Sci. Eng., 2025, 11, 5682
DOI: 10.1021/acsbiomaterials.5c00996

RETRACTED ARTICLE: Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects

Fan Yang, Qiuxia Qin and Juan Liu

Hereditas, 2025, 162
DOI: 10.1186/s41065-025-00443-2

Recombinant collagen in regenerative medicine: Expression strategies, structural design, and translational applications

Huixia He, Mingzhu Ye, Guoqi Cui and Jianxi Xiao

Materials Today Bio, 2025, 35, 102452
DOI: 10.1016/j.mtbio.2025.102452

The treatment of diabetic foot ulcers with advanced nanomaterials

Meng Gu, Shuai Ye, Carmine Coluccini, Coghi Paolo Saul and Yi Zhun Zhu

Nano Ex., 2026, 7, 022001
DOI: 10.1088/2632-959X/ae6356

Enhancing Biological Activity in Skin Repair with a Transdermal Peptide–Recombinant Type III Collagen Hydrogel

Yue Liu and Jingjun Hong

Current Protocols, 2026, 6
DOI: 10.1002/cpz1.70392

Effect of composite biodegradable biomaterials on wound healing in diabetes

Sihang Ren, Shuaichen Guo, Liqun Yang and Chenchao Wang

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.1060026

Modern Approaches in Wounds Management

Simona-Maria Tatarusanu, Florentina-Geanina Lupascu, Bianca-Stefania Profire, Andrei Szilagyi, Ioannis Gardikiotis, Andreea-Teodora Iacob, Iulian Caluian, Lorena Herciu, Tudor-Catalin Giscă, Mihaela-Cristina Baican, Florina Crivoi and Lenuta Profire

Polymers, 2023, 15, 3648
DOI: 10.3390/polym15173648

Microfibrillated cellulose-enhanced carboxymethyl chitosan/oxidized starch sponge for chronic diabetic wound repair

Lin-yu Long, Cheng Hu, Wenqi Liu, Can Wu, Lu Lu, Li Yang and Yun-bing Wang

Biomaterials Advances, 2022, 135, 112669
DOI: 10.1016/j.msec.2022.112669

An injectable carrier for spatiotemporal and sequential release of therapeutic substances to treat myocardial infarction

Wenqi Liu, Cheng Hu, Linyu Long, Shuyi He, Wen Zhang, Zhicun Wang, Li Yang and Yunbing Wang

Journal of Controlled Release, 2024, 365, 29
DOI: 10.1016/j.jconrel.2023.10.056

Wound microenvironment‐responsive peptide hydrogel with multifunctionalities for accelerating wound healing

Weimiao Dong, Haihong Yang, Min Liu, Leixia Mei and Jun Han

Journal of Peptide Science, 2024, 30
DOI: 10.1002/psc.3595

Advances in the Research and Application of Smart-Responsive Hydrogels in Disease Treatment

Juan Cao, Ping Yuan, Bo Wu, Yeqi Liu and Cheng Hu

Gels, 2023, 9, 662
DOI: 10.3390/gels9080662

Immunomodulatory Hydrogels: Advanced Regenerative Tools for Diabetic Foot Ulcer

Yuan Xiong, Qian Feng, Li Lu, Kangkang Zha, Tao Yu, Ze Lin, Yiqiang Hu, Adriana C. Panayi, Vahideh Nosrati‐Ziahmagi, Xiangyu Chu, Lang Chen, Mohammad‐Ali Shahbazi, Bobin Mi and Guohui Liu

Adv Funct Materials, 2023, 33
DOI: 10.1002/adfm.202213066

Combining HUMSC secretome and a conductive hydrogel enhances angiogenesis and electrical transmission at myocardial infarct sites to support cardiac repair

Shu-yi He, Lin-yu Long, Zhi-cun Wang, Wen-qi Liu, Wen Zhang, Cheng Hu, Xiao-feng Wu, Ruiqi Dong, Hong-song Fan, Qing-Jiang, Ying-ying Tong, Guang-hua Yang, Li-Yang and Yun-bing Wang

Chemical Engineering Journal, 2023, 474, 145877
DOI: 10.1016/j.cej.2023.145877

High‐efficiency production of bioactive recombinant human type III collagen in transgenic silkworm cocoons

Shihua Li, Yijiangcheng Li, Zhanpeng Zhang, Dalin Zhu, Kai Chen, Richard Ansah Herman, Sheng Sheng, Jun Wang and Anjiang Tan

Insect Science, 2026
DOI: 10.1111/1744-7917.70271

Effect and mechanism of signal peptide and maltose on recombinant type III collagen production in Pichia pastoris

Xingyin Wang, Pan Wang, Weina Li, Chenhui Zhu and Daidi Fan

Appl Microbiol Biotechnol, 2023, 107, 4369
DOI: 10.1007/s00253-023-12579-0

The promoting effect of Balanus albicostatus cement protein 19k (Balcp19k) on wound healing by regulating fibroblast migration and relieving early-stage inflammation responses

Junyi Song, Ling Zeng, Zijian Ye, Peng Lu, Chengyu Jing, Biru Hu and Hao He

International Journal of Biological Macromolecules, 2025, 289, 138781
DOI: 10.1016/j.ijbiomac.2024.138781

Hydrogen sulfide as a therapeutic agent for diabetic wounds: effects on inflammation and fibroblast pyroptosis

Fusheng Zhao, Yuanyuan Li, Qunying Hu, Jiali Xu, Na Zhang, Yonglan Chen, Xinyue Jiang, Chunfu Gu, Kexin Zhang and Geng Wu

Front. Immunol., 2025, 16
DOI: 10.3389/fimmu.2025.1558443

Microenvironment-responsive collagen hydrogel with Houttuynia Cordata Thunb vesicles for diabetic wound repair

Wenhao Yang, Zheng Xing, Xin Wang, Zhen Xu, Xiaolian Jiang, Jiang Xia, Lin Qiu, Jianda Xu and Jianhao Wang

International Journal of Biological Macromolecules, 2025, 320, 145840
DOI: 10.1016/j.ijbiomac.2025.145840

Platelet Rich Plasma Loaded Multifunctional Hydrogel Accelerates Diabetic Wound Healing via Regulating the Continuously Abnormal Microenvironments

Kui Xu, Sijie Deng, Yabin Zhu, Wei Yang, Weizhen Chen, Liang Huang, Chi Zhang, Ming Li, Lijiao Ao, Yibo Jiang, Xiangyu Wang and Qiqing Zhang

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202301370

A dynamic wet-adhesive hydrogel loaded with ROS-responsive liposomes for chemotherapy-induced oral mucositis treatment

Danya Zhang, Peilin Zhuang, Yunyi Wang, Bingxu Lu, Jiajia Linghu, Yaping Yin, Baohan Xie, Guichao Zhang, Qin Mao and Zhaoqiang Zhang

Colloids and Surfaces B: Biointerfaces, 2026, 258, 115254
DOI: 10.1016/j.colsurfb.2025.115254

Responsive multifunctional hydrogels emulating the chronic wounds healing cascade for skin repair

Wen Zhang, Wenqi Liu, Linyu Long, Shuyi He, Zhicun Wang, Yang Liu, Li Yang, Ningbo Chen, Cheng Hu and Yunbing Wang

Journal of Controlled Release, 2023, 354, 821
DOI: 10.1016/j.jconrel.2023.01.049

Advancements in Clinical Utilization of Recombinant Human Collagen: An Extensive Review

Isaac Wong Kai Jie, Kar Wai Alvin Lee, Song Eun Yoon, Jong Keun Song, Lisa Kwin Wah Chan, Cheuk Hung Lee, Eunji Jeong, Jin-Hyun Kim and Kyu-Ho Yi

Life, 2025, 15, 582
DOI: 10.3390/life15040582

Tissue engineering applications of recombinant human collagen: a review of recent progress

Lili Cao, Zhongfeng Zhang, Dan Yuan, Meiping Yu and Jie Min

Front. Bioeng. Biotechnol., 2024, 12
DOI: 10.3389/fbioe.2024.1358246

Mechanism of medical hemorrhoid gel in relieving pruritus ani via inhibiting the activation of JAK2/STAT3 pathway

Zhongzhu Ai, Dongfeng Yuan, Jingyi Cai, Ruotong Dong, Wei Liu and Daonian Zhou

Front. Med., 2024, 11
DOI: 10.3389/fmed.2024.1487531

On-demand hydrogen sulfide-releasing hydrogel reprogramming the diabetic wound microenvironment to accelerate healing

Zhe Yang, Liujiao Ren, Tian He, Pengfei Yang, Xinyang Liu, Chenna Di, Ronghua Wang, Di Gao, Lin Jin, Chengwei Li and Zhongmin Tian

Biomaterials, 2026, 331, 124129
DOI: 10.1016/j.biomaterials.2026.124129

Smart Wound Dressings and the Biological Parameters They Monitor: A Scoping Review

Sebastian Probst, Alessio Stefanelli, Sophie Groux, Natacha Bossi, Marie‐Therese Pugliese and Damien Pastor

International Wound Journal, 2026, 23
DOI: 10.1111/iwj.70919

Bioarchitectural Design of Bioactive Biopolymers: Structure–Function Paradigm for Diabetic Wound Healing

Shivam Sharma and Anil Kishen

Biomimetics, 2024, 9, 275
DOI: 10.3390/biomimetics9050275

Oligolysine-based hydrogel dressing with antibacterial, anti-inflammatory, and tissue-adhesion activities for infected wound treatment

Jiaming Cui, Yongchang Tian, Bingbing Zhang, Rong Zhang, Jiaxin Li and Li Chen

Colloids and Surfaces B: Biointerfaces, 2024, 243, 114157
DOI: 10.1016/j.colsurfb.2024.114157

Architecturally designed sequential-release hydrogels

Dan Zhang, Zimu Li, Li Yang, Hualin Ma, Hongzhong Chen and Xiaowei Zeng

Biomaterials, 2023, 303, 122388
DOI: 10.1016/j.biomaterials.2023.122388

Stimulus-Responsive Bioactive Hydrogels in Diabetic Wound Healing

Guo Xu, Penghong Xu, Bingbing Gao, Jianlin Chu and Bingfang He

ACS Appl. Nano Mater., 2024, 7, 11037
DOI: 10.1021/acsanm.4c01917

Advanced Responsive Hydrogels for Diabetic Wound Healing: Design Principles, Controlled Drug Delivery, Therapeutic Strategies, and Application Prospects

Jiyuan Du, Caihong Xian, Xiaodan Liang, Shirou Fan, Liying Wang and Jun Wu

MedComm – Biomaterials and Applications, 2025, 4
DOI: 10.1002/mba2.70019

Recent Advances in Nano-Drug Delivery Systems for the Treatment of Diabetic Wound Healing

Mengqian Liu, Xuerong Wei, Zijun Zheng, Yicheng Li, Mengyao Li, Jiabao Lin and Lei Yang

IJN, 2023, Volume 18, 1537
DOI: 10.2147/IJN.S395438

The study on the preparation of mineralized recombinant humanized collagen type I composite by a two-step method and its performance for bone regeneration

Yi Lu, Qi Zhu, Siruo Zhang, Tao Han, Bo Yang and Xiaojie Lian

Materials Today Communications, 2024, 41, 111023
DOI: 10.1016/j.mtcomm.2024.111023

A Recent Insight into Research Pertaining to Collagen-Based Hydrogels as Dressings for Chronic Skin Wounds

Andreea Mariana Negrescu and Anisoara Cimpean

Gels, 2025, 11, 527
DOI: 10.3390/gels11070527

Recent advances in smart‐responsive hydrogels for tissue repairing

Cheng Hu, Li Yang and Yunbing Wang

MedComm – Biomaterials and Applications, 2022, 1
DOI: 10.1002/mba2.23

Application of Collagen-Based Hydrogel in Skin Wound Healing

Yuan Zhang, Yong Wang, Ying Li, Yunpeng Yang, Mingyuan Jin, Xiaoying Lin, Zeming Zhuang, Kai Guo, Tao Zhang and Weiqiang Tan

Gels, 2023, 9, 185
DOI: 10.3390/gels9030185

High-level secretory expression of recombinant type III human-like collagen α1 in Pichia pastoris via multilevel systematic optimization

Jing Wang, Zhi-Xiang Xiang, Meng-Fan Luan, Jin-Song Gong, Chang Su, Heng Li, Zheng-Hong Xu and Jin-Song Shi

International Journal of Biological Macromolecules, 2025, 313, 144270
DOI: 10.1016/j.ijbiomac.2025.144270

Applications of recombinant type III collagen in tissue engineering

Yuchen Shan, Ting Wang and Haiyan Lin

BioMed Eng OnLine, 2025, 24
DOI: 10.1186/s12938-025-01447-9

Hydrogels loaded with different substances for treating heart failure: a promising therapy

Ran Meng, Weiqiang Xiao, Shisen Liang, Jiahui Shen, Hanlin Xu, Haojun Li, Xiaohong Xue, Mingqi Zheng, Xugang Wang and Mei Wei

Front. Cardiovasc. Med., 2026, 13
DOI: 10.3389/fcvm.2026.1744301

Narrative review on nanoparticles based on current evidence: therapeutic agents for diabetic foot infection

Mohd Saleem, Azharuddin Sajid Syed Khaja, Soha Moursi, Tahani Almofeed Altamimi, Mohammed Salem Alharbi, Kauser Usman, Mohd Shahid Khan, Alwaleed Alaskar and Mohammad Jahoor Alam

Naunyn-Schmiedeberg's Arch Pharmacol, 2024, 397, 6275
DOI: 10.1007/s00210-024-03094-8

Acceleration of Wound Healing in Diabetic Rats through a Novel 3D Organo-Hydrogel Nanocomposite of Polydopamine/TiO2 Nanoparticles and Cu (PDA-TiO2@Cu)

Sally A. Elekhtiar, Maha Mohamed Abo Gazia, Azza I. Helal, Hala Mahfouz, Nesma M. El-Kemary, Sherief Abd-Elsalam, Samar Elksass, Hend A. Alkabes, Maged El-Kemary and Marwa M. Abd-Elsalam

EMIDDT, 2025, 25, 198
DOI: 10.2174/0118715303280532240415094718

An endometrial biomimetic extracellular matrix (ECM) for enhanced endometrial regeneration using hyaluronic acid hydrogel containing recombinant human type III collagen

Siying Wei, Ziyi Li, Huan Xia, Zhaoyang Wang, Jingxian Deng, Lu Li, Rufei Huang, Tao Ye, Yadong Huang and Yan Yang

International Journal of Biological Macromolecules, 2024, 268, 131723
DOI: 10.1016/j.ijbiomac.2024.131723

Application of In Situ Mucoadhesive Hydrogel with Anti-Inflammatory and Pro-Repairing Dual Properties for the Treatment of Chemotherapy-Induced Oral Mucositis

Yujie Kang, Yahui Xiong, Bingxu Lu, Yunyi Wang, Danya Zhang, Jinghao Feng, Lei Chen and Zhaoqiang Zhang

ACS Appl. Mater. Interfaces, 2024, 16, 35949
DOI: 10.1021/acsami.4c03217

Exo-hydrogel therapy: a revolutionary approach to managing diabetic complications

Yiming Meng, Jing Sun, Yushu Ma and Cuicui Kong

J Nanobiotechnol, 2025, 23
DOI: 10.1186/s12951-025-03621-6

Using biomaterials to improve mesenchymal stem cell therapies for chronic, nonhealing wounds

Romina Keshavarz, Sara Olsen and Bethany Almeida

Bioengineering & Transla Med, 2024, 9
DOI: 10.1002/btm2.10598

Regeneration of infarcted hearts by myocardial infarction-responsive injectable hydrogels with combined anti-apoptosis, anti-inflammatory and pro-angiogenesis properties

Cheng Hu, Wenqi Liu, Linyu Long, Zhicun Wang, Wen Zhang, Shuyi He, Lu Lu, Hongsong Fan, Li Yang and Yunbing Wang

Biomaterials, 2022, 290, 121849
DOI: 10.1016/j.biomaterials.2022.121849

Recombination humanized type III collagen promotes oral ulcer healing

Xinxing Shuai, Ning Kang, Yuhan Li, Mingxuan Bai, Xinyi Zhou, Yanjun Zhang, Weimin Lin, Hanwen Li, Caojie Liu, Hai Lin and Quan Yuan

Oral Diseases, 2024, 30, 1286
DOI: 10.1111/odi.14540

Characterization of Schiff base self-healing hydrogels by dynamic speckle pattern analysis

Madeh Sajjadi, Ramin Jamali, Tahereh Kiyani, Zahra Mohamadnia and Ali-Reza Moradi

Sci Rep, 2024, 14
DOI: 10.1038/s41598-024-79499-5

Collaborative Enhancement of Diabetic Wound Healing and Skin Regeneration by Recombinant Human Collagen Hydrogel and hADSCs

Weishi Kong, Yulu Bao, Wei Li, Dingding Guan, Yating Yin, Yongqiang Xiao, Shihui Zhu, Yu Sun and Zhaofan Xia

Adv Healthcare Materials, 2024, 13
DOI: 10.1002/adhm.202401012

Development and application of recombinant collagen in dermatology

Le Li, Wan Liu, Xiaofei Xie and Huan Lei

Reactive and Functional Polymers, 2025, 217, 106495
DOI: 10.1016/j.reactfunctpolym.2025.106495

Synergistic Effects of Fractional CO2 Laser and Recombinant Humanized Type III Collagen (rhCol III) in Atrophic Acne Scar Treatment: Activation of MAPK Pathway and Enhanced Collagen Remodeling

Li Gu, Jing Wang, Rong Guo, Zhinan Shi, Zhiyi Xu, Shu Zhou, Jingting Zhao, Liqun Gu, Bingrong Zhou, Hui Hua and Suraiya Saleem

Dermatologic Therapy, 2025, 2025
DOI: 10.1155/dth/6736692

Electrical Microenvironment Reconstruction and the Application of Biomaterials in Spinal Cord Injury

Jie Zhang, Xiangyun Zou, Mengshuang Li and Yaosai Liu

JFB, 2026, 17, 172
DOI: 10.3390/jfb17040172

Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway

Zhongzhu Ai, Dongfeng Yuan, Yun Li, Jingyi Cai, Daonian Zhou and Wei Liu

JIR, 2025, Volume 18, 10619
DOI: 10.2147/JIR.S526589