Lasso Peptide Syanodin I: Loop-Pulling Two-Step Thermal Unthreading Mechanism

Miguel Santos-Fernandez, Kevin Jeanne Dit Fouque, Ukesh Karki, Alain Blond, Séverine Zirah, Prem P. Chapagain, Julian D. Hegemann and Francisco Fernandez-Lima

Anal. Chem., 2025, 97, 25111
DOI: 10.1021/acs.analchem.5c04118

Hyphenation of Trapped Ion Mobility to Two-Dimensional Mass Spectrometry for Protein Analysis in Complex Biomixtures

Callan Littlejohn, Meng Li, Christopher A. Wootton, Mark P. Barrow and Peter B. O’Connor

J. Am. Soc. Mass Spectrom., 2025, 36, 2707
DOI: 10.1021/jasms.5c00292

Trapped Ion Mobility Spectrometry, Ultraviolet Photodissociation, and Time-of-Flight Mass Spectrometry for Gas-Phase Peptide Isobars/Isomers/Conformers Discrimination

Samuel A. Miller, Kevin Jeanne Dit Fouque, Mark E. Ridgeway, Melvin A. Park and Francisco Fernandez-Lima

J. Am. Soc. Mass Spectrom., 2022, 33, 1267
DOI: 10.1021/jasms.2c00091

Direct histone proteoform profiling of the unannotated, endangered coral Acropora cervicornis

Cassandra N Fuller, Sabrina Mansoor, Kevin Jeanne Dit Fouque, Lilian Valadares Tose, Javier Rodriguez-Casariego, Mariangela Kosmopoulou, Detlev Suckau, Francisca N de Luna Vitorino, Benjamin A Garcia, Jose M Eirin-Lopez and Francisco Fernandez-Lima

Nucleic Acids Research, 2025, 53
DOI: 10.1093/nar/gkaf740

Cyclic Peptide Protomer Detection in the Gas Phase: Impact on CCS Measurement and Fragmentation Patterns

Andréa McCann, Christopher Kune, Philippe Massonnet, Johann Far, Marc Ongena, Gauthier Eppe, Loïc Quinton and Edwin De Pauw

J. Am. Soc. Mass Spectrom., 2022, 33, 851
DOI: 10.1021/jasms.2c00035

Ion Mobility Mass Spectrometry (IM-MS) for Structural Biology: Insights Gained by Measuring Mass, Charge, and Collision Cross Section

Emilia Christofi and Perdita Barran

Chem. Rev., 2023, 123, 2902
DOI: 10.1021/acs.chemrev.2c00600

Online, Bottom-up Characterization of Histone H4 4–17 Isomers

Cassandra N. Fuller, Kevin Jeanne Dit Fouque, Lilian Valadares Tose, Francisca N. L. Vitorino, Benjamin A. Garcia and Francisco Fernandez-Lima

Anal. Chem., 2024, 96, 17165
DOI: 10.1021/acs.analchem.4c02549

Broad‐Spectrum Diffusion Coefficient Measurements via Surface Plasmon Resonance: From Thermodynamics to Protein Conformational Disorders

Giuseppe Stefano Basile, Damiano Calcagno, Nunzio Tuccitto, Diego Sbardella and Giuseppe Grasso

ChemPhysChem, 2025, 26
DOI: 10.1002/cphc.202500138

Advancing Cyclic Ion Mobility Mass Spectrometry Methods for Studying Biomolecules: Toward the Conformational Dynamics of Mega Dalton Protein Aggregates

Julian A. Harrison, Adam Pruška, Philipp Bittner, Alexander Muck, Dale A. Cooper-Shepherd and Renato Zenobi

Anal. Chem., 2022, 94, 12435
DOI: 10.1021/acs.analchem.2c02406

Top/Middle-Down Characterization of α-Synuclein Glycoforms

Samuel A. Miller, Kevin Jeanne Dit Fouque, Eldon R. Hard, Aaron T. Balana, Desmond Kaplan, Valery G. Voinov, Mark E. Ridgeway, Melvin A. Park, Gordon A. Anderson, Matthew R. Pratt and Francisco Fernandez-Lima

Anal. Chem., 2023, 95, 18039
DOI: 10.1021/acs.analchem.3c02405

Mapping Native Peptide–Peptide Noncovalent Interactions: Insights from Trapped Ion Mobility Spectrometry, Electron- and UV-Fragmentation, Tandem Mass Spectrometry, and Molecular Dynamics

Miguel Santos-Fernandez, Kevin Jeanne Dit Fouque, Samuel Silva da Rocha Pita, Prem P. Chapagain, Fenfei Leng and Francisco Fernandez-Lima

J. Am. Soc. Mass Spectrom., 2026, 37, 638
DOI: 10.1021/jasms.5c00357

Top-Down Structural Characterization of Native Ubiquitin Combining Solution-Stable Isotope Labeling, Trapped Ion Mobility Spectrometry, and Tandem Electron Capture Dissociation Mass Spectrometry

Kevin Jeanne Dit Fouque, Meiby Fernandez-Rojas, Anelis E. Roque and Francisco Fernandez-Lima

Anal. Chem., 2024, 96, 14963
DOI: 10.1021/acs.analchem.4c03070

A Conformation-Specific Approach to Native Top-down Mass Spectrometry

Hannah M. Britt, Aisha Ben-Younis, Nathanael Page and Konstantinos Thalassinos

J. Am. Soc. Mass Spectrom., 2024, 35, 3203
DOI: 10.1021/jasms.4c00361

Top-“Double-Down” Mass Spectrometry of Histone H4 Proteoforms: Tandem Ultraviolet-Photon and Mobility/Mass-Selected Electron Capture Dissociations

Kevin Jeanne Dit Fouque, Samuel A. Miller, Khoa Pham, Natarajan V. Bhanu, Yarixa L. Cintron-Diaz, Dennys Leyva, Desmond Kaplan, Valery G. Voinov, Mark E. Ridgeway, Melvin A. Park, Benjamin A. Garcia and Francisco Fernandez-Lima

Anal. Chem., 2022, 94, 15377
DOI: 10.1021/acs.analchem.2c03147