Michael Friess, Amit Singh Sahrawat, Bianca Kerschbaumer, Silvia Wallner, Ana Torvisco, Roland Fischer, Karl Gruber, Peter Macheroux and Rolf Breinbauer

ACS Catal., 2024, 14, 7256
DOI: 10.1021/acscatal.4c00276

Catalytic asymmetric dearomatization of phenols via divergent intermolecular (3 + 2) and alkylation reactions

Xiang Gao, Tian-Jiao Han, Bei-Bei Li, Xiao-Xiao Hou, Yuan-Zhao Hua, Shi-Kun Jia, Xiao Xiao, Min-Can Wang, Donghui Wei and Guang-Jian Mei

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-40891-w

Catalytic Asymmetric Synthesis of Aza-Quaternary Carbon Cyclohexadieneones Enabled by Aminative Dearomatization of Phenols

Yu Chen, Shi-Kun Jia, Xiao Xiao, Min-Can Wang, Lihua Huang and Guang-Jian Mei

Org. Lett., 2023, 25, 4740
DOI: 10.1021/acs.orglett.3c01746

Bifunctional Iminophosphorane Catalyzed Amide Enolization for Enantioselective Cyclohexadienone Desymmetrization

Charmaine Y. X. Poh, Daniel Rozsar, Jinchao Yang, Kirsten E. Christensen and Darren J. Dixon

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202315401

Chemoenzymatic and Enantiomeric Switching Regimes Enabling the Synthesis of Homochiral Cyclohexa-2,5-dienones Incorporating All-Carbon Quaternary Centers

Sebastian Ye and Martin G. Banwell

J. Org. Chem., 2021, 86, 15403
DOI: 10.1021/acs.joc.1c01931

Diastereoselective and Regioselective Tunable Cascade Annulation of Prochiral Enone-Tethered Cyclohexadienones

Ramulu Dhanavath, Tarun Nallamilli, Anandarao Munakala, Jagadeesh Babu Nanubolu and Rambabu Chegondi

Org. Lett., 2025, 27, 7879
DOI: 10.1021/acs.orglett.5c02189

Brønsted acid-catalyzed asymmetric [3 + 3] cyclization of para-quinamines: Access to 6/6/6/6-fused tetracyclic 1,2,4-triazinanes

Yan Ding, Feng Lv, Yue Chen, Zhe Liu, Yang Ma, Shiru Li, Dejing Yin, Jian Wen, Yong Rao, Ling Huang and Zengwei Lai

Chinese Chemical Letters, 2025, 112288
DOI: 10.1016/j.cclet.2025.112288

Steric- and Electronic-Controlled Intramolecular [2 + 2]-Cycloaddition of Cyclohexadienone-Containing 1,7-Enynes

Anandarao Munakala, Tarun Nallamilli, Jagadeesh Babu Nanubolu and Rambabu Chegondi

Org. Lett., 2022, 24, 892
DOI: 10.1021/acs.orglett.1c04232

Palladium(0)-Catalyzed Remote Decarboxylative Allylation and Base-Mediated 1,3-Migration

Ashok Donthoju, Anandarao Munakala, Sushma Ellandula and Rambabu Chegondi

J. Org. Chem., 2022, 87, 8267
DOI: 10.1021/acs.joc.2c00961

Enantioselective Total Synthesis of (+)‐Incargranine A Enabled by Bifunctional Iminophosphorane and Iridium Catalysis

Anna A. M. Miller, Phillip Biallas, Benjamin D. A. Shennan and Darren J. Dixon

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202314308

Gold‐Catalyzed Redox Cycloisomerization/[3+2] Dipolar Cycloaddition Domino Reactions: Construction of Isoxazolidine‐Containing Polycyclic Scaffolds

Wei Zhao, Sining Wang, Haixing Xu, Kun Zhao and Tao Shu

Eur J Org Chem, 2026, 29
DOI: 10.1002/ejoc.202501012

Ene-Reductase-Catalyzed Enantioselective Desymmetrization of Cyclohexadienones: Straightforward Access to All-Carbon Quaternary Stereocenters

Xiaofan Wu, Lin Yang, Zhigang Liu, Ke Zhang, Zedu Huang and Fener Chen

ACS Catal., 2024, 14, 6194
DOI: 10.1021/acscatal.4c00239

Catalyst-Controlled Diastereoselective Synthesis of Bridged [3.3.1] Bis(Indolyl)-Oxanes and Oxepanes via Desymmetrization of Bis(Indolyl)-Cyclohexadienones

Abhishek Kumar Mishra, Anil Chauhan, Santosh Kumar, Ruchir Kant and Ravindra Kumar

Org. Lett., 2023, 25, 3034
DOI: 10.1021/acs.orglett.3c00834

Enantioselective Desymmetrization Triggered by Iminium‐Enamine Activation: Access to Complex Cyclohepta[b]indoles

Lakshmi Revati Magham, Satish B. Thopate, Abdus Samad and Rambabu Chegondi

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202203435

Synthesis of 6/5/3-Fused Tricyclic Scaffolds via Multistep Cascade Cyclization of α-Aryl Vinylsulfoniums with para-Quinamines and para-Quinols

Zhen-Hua Wang, Dong-Qun Huang, Ping Wang, Lei Yang, Yong You, Jian-Qiang Zhao, Yan-Ping Zhang and Wei-Cheng Yuan

Org. Lett., 2024, 26, 5905
DOI: 10.1021/acs.orglett.4c01740

Thiourea‐Promoted Cascade Dihalogenation‐Cyclization of Cyclohexadienone‐Containing 1,6‐Enynes

Jia‐Ying Zhao, Qi Liao, Jian‐Wei Zhang, Guo‐Qiang Lin, Zhengtao Wang, Dingding Gao, Qing‐Hua Li and Ping Tian

Adv Synth Catal, 2023, 365, 482
DOI: 10.1002/adsc.202201185

Asymmetric Synthesis of Hydrophenanthrenones Bearing Multiple Stereogenic Centers via Squaramide-Catalyzed Domino 1,4-/1,4-Addition Desymmetrization Sequence

Manisha Sharma, Tamanna and Pankaj Chauhan

Org. Lett., 2023, 25, 7911
DOI: 10.1021/acs.orglett.3c03167

Carbon-silicon-switch effect in enantioselective construction of silicon-stereogenic center from silacyclohexadienones

Yu Yan, Qi Wei, Zhishan Su, Nan-Nan Hang, Tamio Hayashi and Jialin Ming

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-54241-x

Polycyclic Pyrazoles from Alkynyl Cyclohexadienones and Nonstabilized Diazoalkanes via [3 + 2]-Cycloaddition/[1,5]-Sigmatropic Rearrangement/Aza-Michael Reaction Cascade

Raj Kumar Patel, Priyankar Jha, Anil Chauhan, Ruchir Kant and Ravindra Kumar

Org. Lett., 2024, 26, 839
DOI: 10.1021/acs.orglett.3c03967

Rhodium(I)/Chiral Diene Complexes Catalyzed Asymmetric Desymmetrization of Alkynyl-Tethered 2,5-Cyclohexadienones Through an Arylative Cyclization Cascade

Yu-Yi Cheng, Ting-Shen Kuo, Ping-Yu Wu, Jen-Chieh Hsieh and Hsyueh-Liang Wu

J. Org. Chem., 2024, 89, 4861
DOI: 10.1021/acs.joc.4c00053

Silver-Catalyzed Asymmetric Desymmetrization of Cyclohexadienones via Van Leusen Pyrrole Synthesis

Mohamed Ahmed Abozeid, Hun Young Kim and Kyungsoo Oh

Org. Lett., 2022, 24, 1812
DOI: 10.1021/acs.orglett.2c00240

Organocatalytic Desymmetric Spirocyclization of Enone-Tethered 2,5-Cyclohexadienone with Isoxazolines to Access Enantioenriched Spiro-Fused Scaffolds

Sachin S. Gorad and Prasanta Ghorai

Org. Lett., 2024, 26, 8780
DOI: 10.1021/acs.orglett.4c03103

Yujing Hu, Jie Chen, Shaofang Qi, Hui Wang, Zhaoxuan Zhu, Yongzhen Peng, Wenjing Wang, Guixiang Huang, Zheng Fang, Yuxuan Ye, Zhiguo Wang and Kai Guo

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202501425

Engineered Artificial Carboligase-Catalyzed Stereoselective Michael Addition of Nitroalkane to Cyclohexadienone

Li Zhang, Yushun Sun, Xiaofan Wu, Qi Wang, Zhigang Liu, Yunyun Yang, Zedu Huang and Fener Chen

ACS Catal., 2026, 16, 1447
DOI: 10.1021/acscatal.5c07465

Sc(OTf)3‐Catalyzed Dearomative [3+2] Annulation of 5‐Aminoisoxazoles with Quinone Imine Ketals or Quinone Monoacetals

Yingkun Yan, Min Li, Min Liu, Min Huang, Lianyi Cao, Wenzhe Li and Xiaomei Zhang

Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200067

Silver‐Catalyzed [3+2] Cycloaddition for the Diastereoselective Synthesis of anti‐3‐Substituted Hydroindolin‐2‐Imines

Zhongtao Yang, Xiai Luo, Zhipeng Zhang, Xiaoling Luo, Jia Zheng, Hui Luo and Weiguang Yang

Adv Synth Catal, 2022, 364, 4433
DOI: 10.1002/adsc.202200993

Synthesis of Diastereomeric Hydrobenzofurans and Hydronaphthofurans via an Iodine Reagent-Promoted Intramolecular Dearomatization Reaction

Xinkun An, Haoyun Ma, Tingting Zhang, Guoen Cui, Xie He and Mingan Wang

J. Org. Chem., 2025, 90, 2760
DOI: 10.1021/acs.joc.4c02998

Catalytic Friedel–Crafts Alkylative Desymmetrization of Cyclohexa-2,5-dienones: Access to Linear and Bridged Polycyclic Pyrroles and 3-Arylpyrroles

Raj Kumar Patel, Anil Chauhan, Priyankar Jha, Ruchir Kant and Ravindra Kumar

Org. Lett., 2022, 24, 5422
DOI: 10.1021/acs.orglett.2c02135

Palladium(II)-Catalyzed Desymmetrization of 2-Alkynylbenzoate-Tethered Cyclohexadienones for the Synthesis of Polycyclic Compounds

Archana Rai, Priyam Bajpai, Rama Krishna Gamidi, Kumar Vanka and Utpal Das

Org. Lett., 2025, 27, 5429
DOI: 10.1021/acs.orglett.5c01396

Organocatalytic Asymmetric Desymmetrization of 2,5-Cyclohexadienones: From Single-Bond Formation to Domino Reactions

Manisha Sharma, Vanisha Sodhi, Pragati Sharma and Pankaj Chauhan

Synlett, 2025
DOI: 10.1055/a-2706-0870

Anion-Relay Double Aza-Michael–Michael Cascades to Enone-Tethered Cyclohexadienones: Access to an Intricate Bridged Ring System

Anil Chauhan, Raj Kumar Patel, Akhilesh Yadav, Ruchir Kant and Ravindra Kumar

Org. Lett., 2024, 26, 5602
DOI: 10.1021/acs.orglett.4c01009

Transition‐Metal Catalyzed Stereoselective Desymmetrization of Prochiral Cyclohexadienones

Anandarao Munakala, Mandalaparthi Phanindrudu and Rambabu Chegondi

The Chemical Record, 2021, 21, 3689
DOI: 10.1002/tcr.202100136

Catalytic desymmetrization reactions to synthesize all-carbon quaternary stereocentres

Pengwei Xu, Feng Zhou, Lei Zhu and Jian Zhou

Nat. Synth, 2023, 2, 1020
DOI: 10.1038/s44160-023-00406-3

Asymmetric Direct/Stepwise Dearomatization Reactions Involving Hypervalent Iodine Reagents

Ravi Kumar, Fateh V. Singh, Naoko Takenaga and Toshifumi Dohi

Chemistry An Asian Journal, 2022, 17
DOI: 10.1002/asia.202101115

Bifunctional Iminophosphorane Catalyzed Amide Enolization for Enantioselective Cyclohexadienone Desymmetrization

Charmaine Y. X. Poh, Daniel Rozsar, Jinchao Yang, Kirsten E. Christensen and Darren J. Dixon

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202315401

Asymmetric Organocatalyzed Intermolecular Functionalization of Cyclohexanone‐Derived Dienones

Corinne Coutant, Paul De Bonfils, Pierrick Nun and Vincent Coeffard

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300042

Progress in the Synthesis of Hydrobenzofurans from O-Cyclohexadienone-tethered 1,6-Enynes

Zhiqing Li, Xiaoyang Qiu, Nan Meng and Zhuqing Liu

Chinese Journal of Organic Chemistry, 2021, 41, 4306
DOI: 10.6023/cjoc202105029

Desymmetrization of Cyclohexadienones via [3+2]/[2+1] Domino Annulation: Access to Cyclopropane Fused Tricyclic Enones

Yannan Zhu, Sen Wang, Bo Fang, Qiuyun Li, Gang Qi and Zhongfei Han

Adv Synth Catal, 2024, 366, 2939
DOI: 10.1002/adsc.202400261

Atom Economical Photocatalytic Oxidation of Phenols and Site-Selective Epoxidation Toward Epoxyquinols

Louis Péault, Aurélien Planchat, Pierrick Nun, Erwan Le Grognec and Vincent Coeffard

J. Org. Chem., 2021, 86, 18192
DOI: 10.1021/acs.joc.1c02459

Combined Lewis Acid Catalyzed Diastereoselective Halogenative Cascade Annulation of Enone-Tethered Cyclohexadienones

Tarun Nallamilli, Anandarao Munakala and Rambabu Chegondi

Org. Lett., 2023, 25, 8240
DOI: 10.1021/acs.orglett.3c03269

Dearomatization drives complexity generation in freshwater organic matter

Siyu Li, Mourad Harir, David Bastviken, Philippe Schmitt-Kopplin, Michael Gonsior, Alex Enrich-Prast, Juliana Valle and Norbert Hertkorn

Nature, 2024, 628, 776
DOI: 10.1038/s41586-024-07210-9

Phenyliodine(III) diacetate-mediated dearomatization of 2-(2-hydroxyaryl)benzoxazoles and 2-(2-hydroxyaryl)benzothiazoles: Regio- and stereoselective synthesis of tetramethoxycyclohexenones and bicyclo[2.2.2]octenones

Geeta Yadav, Sunil Kumar, Devinder Kumar, Ramesh Kataria, Christophe Laroche and Sean M. Kerwin

Journal of Molecular Structure, 2022, 1266, 133520
DOI: 10.1016/j.molstruc.2022.133520

Asymmetric Synthesis of Hydroindoles via Desymmetrizing [3+2] Annulation of p-Quinamines and Arylalkylketenes

Qianping Chen, Yan Zhang, Yanji Song, Yang Zhang, Zhishan Su, Xiaoming Feng and Xiaohua Liu

Org. Lett., 2024, 26, 3366
DOI: 10.1021/acs.orglett.4c00780

Enantioselective desymmetrization reactions in asymmetric catalysis

Carmen Nájera, Francisco Foubelo, José M. Sansano and Miguel Yus

Tetrahedron, 2022, 106-107, 132629
DOI: 10.1016/j.tet.2022.132629

Tandem Enantioselective Cycloaromatization/Intramolecular Friedel–Crafts Desymmetrization of Cyclohexadienones

Daniel Gaviña, Marta Durán, Lidia Prieto, Marcos Escolano, Santiago Díaz‐Oltra, María Sánchez‐Roselló and Carlos del Pozo

Adv Synth Catal, 2024, 366, 3881
DOI: 10.1002/adsc.202400576

Rhodium-Catalyzed Desymmetric Arylation of γ,γ-Disubsituted Cyclohexadienones: Asymmetric Synthesis of Chiral All-Carbon Quaternary Centers

Yu Qiao, Shiming Bai, Xiao-Feng Wu, Ying Yang, He Meng and Jialin Ming

Org. Lett., 2022, 24, 1556
DOI: 10.1021/acs.orglett.2c00225

Rhodium(III)-Catalyzed Asymmetric Reductive Cyclization of Cyclohexadienone-Containing 1,6-Dienes via an Anti-Michael/Michael Cascade Process

Hao Xu, Yun-Xuan Tan, Pei-Pei Xie, Rui Ding, Qi Liao, Jian-Wei Zhang, Qing-Hua Li, Yu-Hui Wang, Xin Hong, Guo-Qiang Lin and Ping Tian

ACS Catal., 2021, 11, 8015
DOI: 10.1021/acscatal.1c02431

Design and Synthesis of Planar-Chiral Oxazole–Pyridine N,N-Ligands: Application in Palladium-Catalyzed Asymmetric Acetoxylative Cyclization

Yu-Qing Bai, Xin-Wei Wang, Bo Wu, Xiao-Qing Wang, Rong-Zheng Liao, Man Li and Yong-Gui Zhou

ACS Catal., 2023, 13, 9829
DOI: 10.1021/acscatal.3c01163

Copper-Catalyzed Enantioselective Desymmetric Protosilylation of Prochiral Diynes: Access to Optically Functionalized Tertiary Alcohols

Zhi-Yuan Chen, Meng-Wei Yang, Zi-Lu Wang and Yun-He Xu

Org. Lett., 2023, 25, 5242
DOI: 10.1021/acs.orglett.3c01702

Divergent Synthesis of Multisubstituted Hydroindole Derivatives via [3+2] Annulations of p‐Quinamines with Nitroalkenes

Hao Qin, Didi Liu, Bingrui Wan, Zhe Liu, Yan Ding, Haonan Zong, Yi Huang, Liang‐Hua Zou and Zengwei Lai

Adv Synth Catal, 2024, 366, 4654
DOI: 10.1002/adsc.202400647

Copper‐Catalyzed Olefination of 4‐CF3‐Substituted Cyclohexadienones Using Sulfonylmethyl Isocyanides: An Electrostatic Repulsion‐Controlled Regioselectivity Switch Strategy

Seungwon Lee, Mohamed Ahmed Abozeid, Hun Young Kim and Kyungsoo Oh

Adv Synth Catal, 2023, 365, 600
DOI: 10.1002/adsc.202201333

Recent advances towards organocatalytic enantioselective desymmetrizing reactions

Yin Xu, Tong-Yi Zhai, Zhou Xu and Long-Wu Ye

Trends in Chemistry, 2022, 4, 191
DOI: 10.1016/j.trechm.2021.12.010

Solvent-Mediated Enantioselective Rauhut–Currier Cyclization via Iminium and Enamine Activation

Satish B. Thopate, Lakshmi Revati Magham, Shrabani Dinda and Rambabu Chegondi

Org. Lett., 2023, 25, 1072
DOI: 10.1021/acs.orglett.2c04249

Reaction of 4-(Alkynyloxy)cyclohexa-2,5-dienones with Dimethyl Sulfoxide: A Catalyst-Free Formation of 6/5/3-Fused Tricyclic Enones

Archana Rai and Utpal Das

J. Org. Chem., 2025, 90, 653
DOI: 10.1021/acs.joc.4c02553

Enantioselective Total Synthesis of (+)‐Incargranine A Enabled by Bifunctional Iminophosphorane and Iridium Catalysis

Anna A. M. Miller, Phillip Biallas, Benjamin D. A. Shennan and Darren J. Dixon

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202314308

Asymmetric Synthesis of Cyclohexenone-Fused Isochromans via Quinidine-Catalyzed Domino Peroxyhemiacetalization/Oxa-Michael Addition/Desymmetrization Sequence

Tamanna, Yaseen Hussain, Deepak Sharma and Pankaj Chauhan

J. Org. Chem., 2022, 87, 6397
DOI: 10.1021/acs.joc.2c00215

[2 + 3] Cycloaddition of para-Quinamines and para-Quinols with C,N-Cyclic Azomethine Imines: Access to 6/5/6/6-Fused Tetracyclic Pyrazolidines

Zhe Liu, Yan Ding, Mingbin Chen, Feng Lv, Ting Xiao, Wen-Bin Liu, Bingrui Wan, Ling Huang, Yong Rao and Zengwei Lai

Org. Lett., 2025, 27, 6257
DOI: 10.1021/acs.orglett.5c01087

Enantiodivergent Cyclization of Racemic Cyclohexadienones via Parallel Kinetic Asymmetric Transformation

Xiang Gao, Bei-Bei Li, Yu-Wei Li, Xiao Xiao, Meng-Meng Liu and Guang-Jian Mei

Org. Lett., 2024, 26, 6290
DOI: 10.1021/acs.orglett.4c02396

Yujing Hu, Jie Chen, Shaofang Qi, Hui Wang, Zhaoxuan Zhu, Yongzhen Peng, Wenjing Wang, Guixiang Huang, Zheng Fang, Yuxuan Ye, Zhiguo Wang and Kai Guo

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202501425

Nickel-Catalyzed Cascade Carbocyclization/Alkenylation of Bisallenes and Organoboronic Acids

Xiao-Die An, Tao Wang, Ji-Xun Guan, Yun-Xuan Tan and Ping Tian

Org. Lett., 2025, 27, 7614
DOI: 10.1021/acs.orglett.5c02170