Red-shifted backbone N–H photocaging agents

Alicia E. Mangubat-Medina, Hallie O. Trial, Reyner D. Vargas, Mekedlawit T. Setegne, Taysir Bader, Mark D. Distefano and Zachary T. Ball

Org. Biomol. Chem., 2020, 18, 5110
DOI: 10.1039/D0OB00923G

Triggering biological processes: methods and applications of photocaged peptides and proteins

Alicia E. Mangubat-Medina and Zachary T. Ball

Chem. Soc. Rev., 2021, 50, 10403
DOI: 10.1039/D0CS01434F

Two-photon uncaging of bioactive thiols in live cells at wavelengths above 800 nm

Matthew D. Hammers, Michael H. Hodny, Taysir K. Bader, M. Mohsen Mahmoodi, Sifei Fang, Alexander D. Fenton, Kadiro Nurie, Hallie O. Trial, Feng Xu, Andrew T. Healy, Zachary T. Ball, David A. Blank and Mark D. Distefano

Org. Biomol. Chem., 2021, 19, 2213
DOI: 10.1039/D0OB01986K

Pro-fluorescent ethynylthiophene-based o-nitrobenzyl photolabile protecting group for hydroxamic acid synthesis

Albert D. Campbell, Lingaraju Gorla, Ophelia Adjei-Sah, Blaise Williams, Stephen O. Ajagbe, Samer Gozem, Mohammad A. Halim and Carl Jacky Saint-Louis

Org. Biomol. Chem., 2025
DOI: 10.1039/D5OB00859J

Optical control of targeted protein degradation

Martin Reynders and Dirk Trauner

Cell Chemical Biology, 2021, 28, 969
DOI: 10.1016/j.chembiol.2021.05.010

Seeing and Cleaving: Turn-Off Fluorophore Uncaging and Its Application in Hydrogel Photopatterning and Traceable Neurotransmitter Photocages

Orsolya Pantl, Balázs Chiovini, Gergely Szalay, Gábor Turczel, Ervin Kovács, Zoltán Mucsi, Balázs Rózsa and Levente Cseri

ACS Appl. Mater. Interfaces, 2024
DOI: 10.1021/acsami.4c10861

Visible-to-NIR-Light Activated Release: From Small Molecules to Nanomaterials

Roy Weinstain, Tomáš Slanina, Dnyaneshwar Kand and Petr Klán

Chem. Rev., 2020, 120, 13135
DOI: 10.1021/acs.chemrev.0c00663

Smart Nucleic Acids as Future Therapeutics

Jiahui Zhang and Khalid Salaita

Trends in Biotechnology, 2021, 39, 1289
DOI: 10.1016/j.tibtech.2021.03.007

Light‐Controlled Cell‐Cycle Arrest and Apoptosis

Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube and Esther Zanin

Angew Chem Int Ed, 2021, 60, 1187
DOI: 10.1002/anie.202008267

Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function

Anirban Bardhan, Wes Brown, Savannah Albright, Michael Tsang, Lance A. Davidson and Alexander Deiters

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202318773

Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π‐Electron Caging Chromophore

Matthew T. Richers, Stefan Passlick, Hitesh Agarwal and Graham C. R. Ellis‐Davies

Angewandte Chemie, 2019, 131, 12214
DOI: 10.1002/ange.201906067

Boosting the Release of Leaving Group from Blebbistatin Derivative Photocages via Enhancing Intramolecular Charge Transfer and Stabilizing Cationic Intermediate

Zicong Situ, Manlin Lu, Wenbin Chen, Zuoti Xie, Shun Li Chen, Li Dang and Ming-De Li

J. Phys. Chem. Lett., 2023, 14, 11580
DOI: 10.1021/acs.jpclett.3c02970

Efficient Activation of 6‐Nitropiperonyloxymethylene (NPOM)‐Caged Nucleosides with Visible Light

Anirban Bardhan and Alexander Deiters

ChemPhotoChem, 2023, 7
DOI: 10.1002/cptc.202200218

Wavelength-Selective Uncaging of Two Different Photoresponsive Groups on One Effector Molecule for Light-Controlled Activation and Deactivation

Isam Elamri, Chahinez Abdellaoui, Jasleen Kaur Bains, Katharina Felicitas Hohmann, Santosh Lakshmi Gande, Elke Stirnal, Josef Wachtveitl and Harald Schwalbe

J. Am. Chem. Soc., 2021, 143, 10596
DOI: 10.1021/jacs.1c02817

Design, Synthesis and Evaluation of Novel Carbazole‐Derived Photocages

Zhipeng Wang and Stephen F. Martin

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202200311

Methods for Three-Dimensional All-Optical Manipulation of Neural Circuits

Emiliano Ronzitti, Valentina Emiliani and Eirini Papagiakoumou

Front. Cell. Neurosci., 2018, 12
DOI: 10.3389/fncel.2018.00469

Guiding Lights: Tissue Bioprinting Using Photoactivated Materials

Mihyun Lee, Riccardo Rizzo, František Surman and Marcy Zenobi-Wong

Chem. Rev., 2020, 120, 10950
DOI: 10.1021/acs.chemrev.0c00077

Dendrimer Conjugation Enables Multiphoton Chemical Neurophysiology Studies with an Extended π‐Electron Caging Chromophore

Matthew T. Richers, Stefan Passlick, Hitesh Agarwal and Graham C. R. Ellis‐Davies

Angew Chem Int Ed, 2019, 58, 12086
DOI: 10.1002/anie.201906067

Long-wavelength photoremovable protecting groups: On the way to in vivo application

Aleksey Yu. Vorobev and Alexander E. Moskalensky

Computational and Structural Biotechnology Journal, 2020, 18, 27
DOI: 10.1016/j.csbj.2019.11.007

Photo- and Ca2+- induced acceleration of uncaging process from hemiacetal intermediate formed in the photolysis of an o-nitrobenzyl type of photoremovable protecting group (photocage)

Tam Thi Thanh Tran and Manabu Abe

Journal of Photochemistry and Photobiology A: Chemistry, 2025, 462, 116230
DOI: 10.1016/j.jphotochem.2024.116230

Development of photolabile protecting groups and their application to the optochemical control of cell signaling

Anirban Bardhan and Alexander Deiters

Current Opinion in Structural Biology, 2019, 57, 164
DOI: 10.1016/j.sbi.2019.03.028

Light‐Controlled Cell‐Cycle Arrest and Apoptosis

Edgar Uhl, Friederike Wolff, Sriyash Mangal, Henry Dube and Esther Zanin

Angewandte Chemie, 2021, 133, 1207
DOI: 10.1002/ange.202008267

Chromatic Selectivity of Coumarin‐Caged Oligonucleotides

Janik Kaufmann, Fabian Sinsel and Alexander Heckel

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202204014

Development of visible-light-activatable photocaged PROTACs

Weizhi Weng, Gang Xue and Zhengying Pan

European Journal of Medicinal Chemistry, 2024, 265, 116062
DOI: 10.1016/j.ejmech.2023.116062

Dextran-Conjugated Caged siRNA Nanoparticles for Photochemical Regulation of RNAi-Induced Gene Silencing in Cells and Mice

Changmai Chen, Zhongyu Wang, Jinhao Zhang, Xinli Fan, Luzheng Xu and Xinjing Tang

Bioconjugate Chem., 2019, 30, 1459
DOI: 10.1021/acs.bioconjchem.9b00204

Selective Modification for Red‐Shifted Excitability: A Small Change in Structure, a Huge Change in Photochemistry

Yvonne Becker, Sina Roth, Maximilian Scheurer, Andreas Jakob, Daniel A. Gacek, Peter J. Walla, Andreas Dreuw, Josef Wachtveitl and Alexander Heckel

Chemistry A European J, 2021, 27, 2212
DOI: 10.1002/chem.202003672

Using photocaging for fast time-resolved structural biology studies

Diana C. F. Monteiro, Emmanuel Amoah, Cromarte Rogers and Arwen R. Pearson

Acta Crystallogr D Struct Biol, 2021, 77, 1218
DOI: 10.1107/S2059798321008809

Generation of a caged lentiviral vector through an unnatural amino acid for photo-switchable transduction

Yan Wang, Shuai Li, Zhenyu Tian, Jiaqi Sun, Shuobin Liang, Bo Zhang, Lu Bai, Yuanjie Zhang, Xueying Zhou, Sulong Xiao, Qiang Zhang, Lihe Zhang, Chuanling Zhang and Demin Zhou

Nucleic Acids Research, 2019, 47, e114
DOI: 10.1093/nar/gkz659

Direct Activation of Nucleobases with Small Molecules for the Conditional Control of Antisense Function

Anirban Bardhan, Wes Brown, Savannah Albright, Michael Tsang, Lance A. Davidson and Alexander Deiters

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202318773

Multiwavelength Control of Mixtures Using Visible Light-Absorbing Photocages

Julie A. Peterson, Ding Yuan and Arthur H. Winter

J. Org. Chem., 2021, 86, 9781
DOI: 10.1021/acs.joc.1c00658

Remotely controlled opening of delivery vehicles and release of cargo by external triggers

Dingcheng Zhu, Sathi Roy, Ziyao Liu, Horst Weller, Wolfgang J. Parak and Neus Feliu

Advanced Drug Delivery Reviews, 2019, 138, 117
DOI: 10.1016/j.addr.2018.10.003

Study on factors affecting quantum yield for the design of improved ortho-nitrobenzyl photoremovable protecting groups

Linh Tran Bao Nguyen and Manabu Abe

Bulletin of the Chemical Society of Japan, 2024, 97
DOI: 10.1093/bulcsj/uoae067

Conditionally Activatable Visible-Light Photocages

Márton Bojtár, Krisztina Németh, Farkas Domahidy, Gergely Knorr, András Verkman, Mihály Kállay and Péter Kele

J. Am. Chem. Soc., 2020, 142, 15164
DOI: 10.1021/jacs.0c07508

Inactivation of Competitive Decay Channels Leads to Enhanced Coumarin Photochemistry

Robin Klimek, Marvin Asido, Volker Hermanns, Stephan Junek, Josef Wachtveitl and Alexander Heckel

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202200647

Rhodamine‐Sensitized Two‐Photon Activation of a Red Light‐Absorbing BODIPY Photocage

Rebekka Weber, Kerby Chok, Stephan Junek, Clemens Glaubitz and Alexander Heckel

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202300149

Photoactivable AIEgen-based Lipid-Droplet-Specific Drug Delivery Model for Live Cell Imaging and Two-Photon Light-Triggered Anticancer Drug Delivery

Amit Kumar Singh, Rakesh Mengji, Asha V Nair, Sk. Sheriff Shah, Jana Avijit and N. D. Pradeep Singh

ACS Appl. Bio Mater., 2023, 6, 4372
DOI: 10.1021/acsabm.3c00580

Rethinking Uncaging: A New Antiaromatic Photocage Driven by a Gain of Resonance Energy

Volker Hermanns, Maximilian Scheurer, Nils Frederik Kersten, Chahinez Abdellaoui, Josef Wachtveitl, Andreas Dreuw and Alexander Heckel

Chemistry A European J, 2021, 27, 14121
DOI: 10.1002/chem.202102351