Advances in pyrazolo[1,5-a]pyrimidines: synthesis and their role as protein kinase inhibitors in cancer treatment

Terungwa H. Iorkula, Osasere Jude-Kelly Osayawe, Daniel A. Odogwu, Latifat Oluwatobi Ganiyu, Emmanuel Faderin, Raymond Femi Awoyemi, Busayo Odunayo Akodu, Ikhazuagbe Hilary Ifijen, Omowunmi Rebecca Aworinde, Peter Agyemang and Odo Lovelyn Onyinyechi

RSC Adv., 2025, 15, 3756
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Design, synthesis, theoretical study, antioxidant, and anticholinesterase activities of new pyrazolo-fused phenanthrolines

Efraín Polo-Cuadrado, Cristian Rojas-Peña, Karen Acosta-Quiroga, Lorena Camargo-Ayala, Iván Brito, Jonathan Cisterna, Félix Moncada, Jorge Trilleras, Yeray A. Rodríguez-Núñez and Margarita Gutierrez

RSC Adv., 2022, 12, 33032
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GreenMedChem: the challenge in the next decade toward eco-friendly compounds and processes in drug design

Carola Castiello, Pierre Junghanns, Annika Mergel, Claus Jacob, Christian Ducho, Sergio Valente, Dante Rotili, Rossella Fioravanti, Clemens Zwergel and Antonello Mai

Green Chem., 2023, 25, 2109
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Piperonal chalcone derivative incorporating the pyrazolo[3,4-b]pyridine moiety; crystal structure, spectroscopic characterization and quantum chemical investigations

Efraín Polo-Cuadrado, Karoll Ferrer, Edison Osorio, Iván Brito, Jonathan Cisterna, Luis Espinoza, Joel B. Alderete and Margarita Gutiérrez

RSC Adv., 2023, 13, 5197
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Modular and selective synthesis of pyrazolo-azepino-centred polycyclic aromatic and non-aromatic architectures

Ting Chen, Jin-Tian Ma, Xiang-Long Chen, You Zhou, Zhi-Cheng Yu, Shuang-Gui Lei, Yan-Dong Wu, Jia-Chen Xiang and An-Xin Wu

Org. Chem. Front., 2023, 10, 4122
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1H-Pyrazolo[3,4-b]quinolines: Synthesis and Properties over 100 Years of Research

Andrzej Danel, Ewa Gondek, Mateusz Kucharek, Paweł Szlachcic and Arkadiusz Gut

Molecules, 2022, 27, 2775
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Water an Eco-Friendly Crossroad in Green Extraction: An Overview

Dasha Mihaylova and Anna Lante

TOBIOTJ, 2019, 13, 155
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Ultrasound irradiation in heterocycle synthesis: An overview

Salim Saranya, Sankaran Radhika, Cheriya Mukkolakkal Afsina Abdulla and Gopinathan Anilkumar

Journal of Heterocyclic Chem, 2021, 58, 1570
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Recent Advances in Synthesis and Properties of Pyrazoles

María-Camila Ríos and Jaime Portilla

Chemistry, 2022, 4, 940
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One-pot Multicomponent Synthesis of Hydrazinyl Thiazoles Bearing an Isatin Moiety in Aqueous Medium

Kooi-Mow Sim, Li-Ping Chung, Kit-Lin Tan, Yee-Ting Tan, Xin-Lee Kee and Kah-Cheng Teo

LOC, 2024, 21, 192
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Triethylammonium Hydrogen Sulfate [Et3NH][HSO4]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-d]pyrimidine and Pyrazolo[3,4-b]pyridine Hybrids

Chetan Jadhav, Amol Nipate, Asha Chate and Charansingh Gill

ACS Omega, 2021, 6, 18215
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Synthesis of Fluorescent 1,7-Dipyridyl-bis-pyrazolo[3,4-b:4′,3′-e]pyridines: Design of Reversible Chemosensors for Nanomolar Detection of Cu2+

Mauricio García, Iván Romero and Jaime Portilla

ACS Omega, 2019, 4, 6757
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Synthesis of new magnetic nanocatalyst Fe3O4@CPTMO-phenylalanine-Ni and its catalytic effect in the preparation of substituted pyrazoles

Samaneh Bikas, Ahmad Poursattar Marjani, Sepideh Bibak and Hamideh Sarreshtehdar Aslaheh

Sci Rep, 2023, 13
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The use of ultrasound in the South Cone region. Advances in organic and inorganic synthesis and in analytical methods

Marcos J. Lo Fiego, Anabela S. Lorenzetti, Gustavo F. Silbestri and Claudia E. Domini

Ultrasonics Sonochemistry, 2021, 80, 105834
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Synthesis of pyrimido[4,5- b ]quinolindiones and formylation: ultrasonically assisted reactions

Jorge Trilleras, Andrés Charris-Molina, Alfredo Pérez-Gamboa, Paola Acosta-Guzman and Jairo Quiroga

R. Soc. Open Sci., 2024, 11
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Synthesis of Pyrazolo-Fused 4-Azafluorenones in an Ionic Liquid. Mechanistic Insights by Joint Studies Using DFT Analysis and Mass Spectrometry

Efraín Polo, Valentina Arce-Parada, Xaviera A. López-Cortés, Jesús Sánchez-Márquez, Alejandro Morales-Bayuelo, Oscar Forero-Doria and Margarita Gutiérrez

Catalysts, 2019, 9, 820
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5-(Indol-2-yl)pyrazolo[3,4-b]pyridines as a New Family of TASK-3 Channel Blockers: A Pharmacophore-Based Regioselective Synthesis

David Ramírez, Melissa Mejia-Gutierrez, Braulio Insuasty, Susanne Rinné, Aytug K. Kiper, Magdalena Platzk, Thomas Müller, Niels Decher, Jairo Quiroga, Pedro De-la-Torre and Wendy González

Molecules, 2021, 26, 3897
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A Review on Microwave‐Assisted Synthesis of Fused N‐Containing Bioactive Heterocyclic Molecules

Raju Kumar Sarma, Ayesha Aktar Khanam Choudhury and Nayana Adhikari

ChemistrySelect, 2026, 11
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Green synthesis of biologically active heterocycles of medicinal importance: a review

R. Nishanth Rao, Sushovan Jena, Manjima Mukherjee, Barnali Maiti and Kaushik Chanda

Environ Chem Lett, 2021, 19, 3315
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Synthesis of heterocyclic compounds via Michael and Hantzsch reactions

Amna M. Abdella, Amr M. Abdelmoniem, Ismail A. Abdelhamid and Ahmed H. M. Elwahy

Journal of Heterocyclic Chem, 2020, 57, 1476
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Design, synthesis, and characterization of novel pyrazolopyridine and pyridopyrazolopyrimidine derivatives

Reda M. Keshk

Journal of Heterocyclic Chem, 2022, 59, 1768
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3-(3,4-Dimethoxyphenyl)-5-(2-fluorophenyl)-1-phenyl-4,5-dihydro-1H-pyrazole

Adel Zamri, Hilwan Y. Teruna, Sri Wulansari, Noval Herfindo, Neni Frimayanti and Ihsan Ikhtiarudin

Molbank, 2019, 2019, M1088
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Advances in the Synthesis of Heteroaromatic Hybrid Chalcones

Ajay Mallia and Joseph Sloop

Molecules, 2023, 28, 3201
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Synthesis of pyrazolopyridine and pyrazoloquinoline derivatives by one-pot, three-component reactions of arylglyoxals, 3-methyl-1-aryl-1H-pyrazol-5-amines and cyclic 1,3-dicarbonyl compounds in the presence of tetrapropylammonium bromide

Ahmad Poursattar Marjani, Jabbar Khalafy and Somayeh Akbarzadeh

Green Processing and Synthesis, 2019, 8, 533
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Single crystal structure, thermal stability and theoretical studies of ethyl 4-(4-(dimethylamino)phenyl)-3,6-dimethyl-1-phenyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

Efraín Polo-Cuadrado, Karoll Ferrer, Oscar Forero-Doria, Alejandro Morales-Bayuelo, Iván Brito, Jonathan Cisterna, Luis Espinoza, Jesús Sánchez-Márquez and Margarita Gutiérrez

Journal of Molecular Structure, 2022, 1260, 132826
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Claisen-Schmidt, aza-Michael, cyclization via cascade strategy toward microwave promoted synthesis of imidazo[2,1-b]quinazolines

Duraipandi Devi Priya and Selvaraj Mohana Roopan

Synthetic Communications, 2020, 50, 1813
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Recent Advances of Indium(III) Chloride Catalyzed Reactions in Organic Synthesis

Mrityunjoy Datta

ChemistrySelect, 2021, 6, 187
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Green Chemistry in the Synthesis of Pharmaceuticals

Supratik Kar, Hans Sanderson, Kunal Roy, Emilio Benfenati and Jerzy Leszczynski

Chem. Rev., 2022, 122, 3637
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Síntesis asistida por ultrasonido de Pirazolo[3,4-b]Piridinas policíclicas fusionadas

Jorge Trilleras, Freddy Ríos-De-La-Rotta and Luis-Felipe Pedroza-García

Rev. Cient., 2023, 47, 1
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Novel Pyrazolo[3,4‐b]pyridines: Synthesis, Molluscicidal, and Antimicrobial Activities

Ahmed Abdou O. Abeed, Sarra Rafrafi, Heba Alsharif, Tarek H. Afifi, Sahar I. M. Abd El‐Wahed and Hesham A. M. Ibrahim

Chemistry & Biodiversity, 2026, 23
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Research on synthesis of microwave‐assisted heterocyclic compounds with eco‐friendly solvents and transition metals via C–H activation

Woo‐Jin Park, Ye Ri Han and Hyejeong Lee

Bulletin Korean Chem Soc, 2026
DOI: 10.1002/bkcs.70127

Unexpected discovery: “A new 3,3′-bipyrazolo[3,4-b]pyridine scaffold and its comprehensive analysis”

Efraín Polo-Cuadrado, Karoll Ferrer, Jesús Sánchez-Márquez, Andrés Charris-Molina, Yeray A. Rodríguez-Núñez, Luis Espinoza-Catalán and Margarita Gutiérrez

Heliyon, 2024, 10, e32573
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Recent Progress in the Synthetic Methods of Pyrazoloquinoline Derivatives

Rita M. Borik, Mohamed S. Mostafa, Mohamed S. Behalo and Rizk E. Khidre

COC, 2024, 28, 117
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Multicomponent Reactions Using C,N-Binucleophilic Nature of Aminopyrazoles: Construction of Pyrazole-Fused Heterocycles

Tasneem Parvin

Top Curr Chem (Z), 2023, 381
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Indane-1,3-dione: Versatile precursor for the microwave-assisted synthesis of annulated and spiro-molecular systems

Sherif M. H. Sanad and Ibrahim S. Sanad

Synthetic Communications, 2025, 55, 1045
DOI: 10.1080/00397911.2025.2492703

Ethylene Glycol Mediated, Catalyst-Free Synthesis of Bis(pyrazolo) pyridines and Their Photophysical Studies

Markabandhu Shanthi, Ravichandran Janani, Arulmozhi Puhazhendhi, Bhaskaran Shankar, Soumya Sivalingam and Subburethinam Ramesh

Synthesis, 2025, 57, 675
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