Hydrotropy and scattering: pre-ouzo as an extended near-spinodal region

Seishi Shimizu and Nobuyuki Matubayasi

Phys. Chem. Chem. Phys., 2017, 19, 26734
DOI: 10.1039/C7CP04990K

PPh4Cl in aqueous solution – the aggregation behavior of an antagonistic salt

Robert Winkler, Thomas Buchecker, Florian Hastreiter, Didier Touraud and Werner Kunz

Phys. Chem. Chem. Phys., 2017, 19, 25463
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Hydrotrope-assisted interconnected mesoporous polyindole-decorated carbon nanotubes: synthesis, characterisation, and fabrication of asymmetric supercapacitor

Shashikant Shivaji Vhatkar, Kumar Abhisek, Helen Treasa Mathew and Ramesh Oraon

New J. Chem., 2023, 47, 14395
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Recent advances in hydrotropic solvent systems for lignocellulosic biomass utilization

Soyeon Jeong, Jiae Ryu, Qiang Yang, J. Y. Zhu and Chang Geun Yoo

Green Chem., 2024, 26, 1806
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Statistical thermodynamic foundation for mesoscale aggregation in ternary mixtures

Seishi Shimizu and Nobuyuki Matubayasi

Phys. Chem. Chem. Phys., 2018, 20, 13777
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Statistical thermodynamics unveils the dissolution mechanism of cellobiose

Thomas W. J. Nicol, Noriyuki Isobe, James H. Clark and Seishi Shimizu

Phys. Chem. Chem. Phys., 2017, 19, 23106
DOI: 10.1039/C7CP04647B

Unifying hydrotropy under Gibbs phase rule

Seishi Shimizu and Nobuyuki Matubayasi

Phys. Chem. Chem. Phys., 2017, 19, 23597
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Assessing the hydrotropic effect in the presence of electrolytes: competition between solute salting-out and salt-induced hydrotrope aggregation

Afonso C. Martins, Jordana Benfica, Germán Peréz-Sanchéz, Seishi Shimizu, Tânia E. Sintra, Nicolas Schaeffer and João A. P. Coutinho

Phys. Chem. Chem. Phys., 2022, 24, 21645
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The impact of the structuring of hydrotropes in water on the mesoscale solubilisation of a third hydrophobic component

Thomas Buchecker, Sebastian Krickl, Robert Winkler, Isabelle Grillo, Pierre Bauduin, Didier Touraud, Arno Pfitzner and Werner Kunz

Phys. Chem. Chem. Phys., 2017, 19, 1806
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Ab initio prediction of structuring/mesoscale inhomogeneities in surfactant-free microemulsions and hydrogen-bonding-free microemulsions

Maximilian Hahn, Sebastian Krickl, Thomas Buchecker, Gašper Jošt, Didier Touraud, Pierre Bauduin, Arno Pfitzner, Andreas Klamt and Werner Kunz

Phys. Chem. Chem. Phys., 2019, 21, 8054
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The impact of the counterion in the performance of ionic hydrotropes

Dinis O. Abranches, Jordana Benfica, Bruna P. Soares, Ana M. Ferreira, Tânia E. Sintra, Seishi Shimizu and João A. P. Coutinho

Chem. Commun., 2021, 57, 2951
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Using coarse-grained molecular dynamics to rationalize biomolecule solubilization mechanisms in ionic liquid-based colloidal systems

Henrique Bastos, Ricardo Bento, Nicolas Schaeffer, João A. P. Coutinho and Germán Pérez-Sánchez

Phys. Chem. Chem. Phys., 2020, 22, 24771
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The impact of size and shape in the performance of hydrotropes: a case-study of alkanediols

Dinis O. Abranches, Bruna P. Soares, Ana M. Ferreira, Seishi Shimizu, Simão P. Pinho and João A. P. Coutinho

Phys. Chem. Chem. Phys., 2022, 24, 7624
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What is better to enhance the solubility of hydrophobic compounds in aqueous solutions: eutectic solvents or ionic liquids?

Olga Ferreira, Liliana P. Silva, Heloísa H. S. Almeida, Jordana Benfica, Dinis O. Abranches, Simão P. Pinho and João A. P. Coutinho

RSC Sustainability, 2024, 2, 4052
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Practical molecular thermodynamics for greener solution chemistry

Steven Abbott, Jonathan J. Booth and Seishi Shimizu

Green Chem., 2017, 19, 68
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Cooperativity in micellar solubilization

Seishi Shimizu and Nobuyuki Matubayasi

Phys. Chem. Chem. Phys., 2021, 23, 8705
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Unveiling the mechanism of hydrotropy: evidence for water-mediated aggregation of hydrotropes around the solute

Dinis O. Abranches, Jordana Benfica, Bruna P. Soares, Alejandro Leal-Duaso, Tânia E. Sintra, Elísabet Pires, Simão P. Pinho, Seishi Shimizu and João A. P. Coutinho

Chem. Commun., 2020, 56, 7143
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Fluctuation adsorption theory: quantifying adsorbate–adsorbate interaction and interfacial phase transition from an isotherm

Seishi Shimizu and Nobuyuki Matubayasi

Phys. Chem. Chem. Phys., 2020, 22, 28304
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Enhanced dissolution of ibuprofen using ionic liquids as catanionic hydrotropes

T. E. Sintra, K. Shimizu, S. P. M. Ventura, S. Shimizu, J. N. Canongia Lopes and J. A. P. Coutinho

Phys. Chem. Chem. Phys., 2018, 20, 2094
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Exploring the impact of sodium salts on hydrotropic solubilization

Jordana Benfica, Afonso C. Martins, Germán Peréz-Sanchéz, Nicolas Schaeffer and João A. P. Coutinho

Phys. Chem. Chem. Phys., 2023, 25, 26327
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Boosting antibiotics performance by new formulations with deep eutectic solvents

Sónia N. Pedro, Ana T.P.C. Gomes, Párástu Oskoei, Helena Oliveira, Adelaide Almeida, Mara G. Freire, Armando J.D. Silvestre and Carmen S.R. Freire

International Journal of Pharmaceutics, 2022, 616, 121566
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Hydrotropically Engineered Polyindole-Encapsulated Flower Shape Nanostructured MoS2 Conductive Framework for Asymmetric Supercapacitors

Shashikant Shivaji Vhatkar, Helen Treasa Mathew, Kumar Abhisek and Ramesh Oraon

ACS Appl. Eng. Mater., 2024, 2, 880
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Superchaotropic Stabilization of Monomeric Protein States

Ben Tin Yan Wong, Lichun Zhang, Thomas Chun Yip Wong, Chun Ngo Yau, Adrian Jun Chu, Tsz Fung Tsang, Joshua Jing Xi Li, Xiao Yang and Hei Ming Lai

Biomacromolecules, 2026, 27, 1138
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Understanding Solute-Hydrotrope Aggregation in Aqueous Solutions: A Molecular Dynamics Approach

Esteban Cea-Klapp, Dinis O. Abranches, Eliseo Marin-Rimoldi, Nicolás F. Gajardo-Parra, Roberto I. Canales, José Matías Garrido and Edward J. Maginn

J. Phys. Chem. B, 2025, 129, 5016
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Enhancing Artemisinin Solubility in Aqueous Solutions: Searching for Hydrotropes based on Ionic Liquids

Isabela Sales, Dinis O. Abranches, Pedro Costa, Tânia E. Sintra, Sónia P.M. Ventura, Silvana Mattedi, João A.P. Coutinho, Mara G. Freire and Simão P. Pinho

Fluid Phase Equilibria, 2021, 534, 112961
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Solubility Enhancement of Vitamins in Water in the Presence of Covitamins: Measurements and ePC-SAFT Predictions

Kamila Wysoczanska, Eugénia A. Macedo, Gabriele Sadowski and Christoph Held

Ind. Eng. Chem. Res., 2019, 58, 21761
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Distinguishing the transitions of fluorescence spectra of tryptophan-134 and 213 in BSA induced by bindings of UV filters, oxybenzone-3, and avobenzone

Megumi Minamide, Minori Tsurushima, Ryotaro Koga, Kanji Hasegawa, Yuya Kurosawa, Tomohiro Tsuchida and Satoru Goto

Bulletin of the Chemical Society of Japan, 2024, 97
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Additive effect between maltodextrins and short food agreed organic acids for rutin and quercetin solubilization in aqueous solutions.

Bastian Mueller, Eva Mueller, Didier Touraud, Anne-Sylvie Fabiano-Tixier and Werner Kunz

Journal of Molecular Liquids, 2025, 434, 128020
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Mechanism of dye solubilization and de-aggregation by urea

James M. Perry, Yu Nagai Kanasaki, Peter B. Karadakov and Seishi Shimizu

Dyes and Pigments, 2021, 193, 109530
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Hydrotropes: Solubilization of nonpolar compounds and modification of surfactant solutions

Lucia Ya. Zakharova, Elmira A. Vasilieva, Alla B. Mirgorodskaya, Sergey V. Zakharov, Rais V. Pavlov, Nadezda E. Kashapova and Gulnara A. Gaynanova

Journal of Molecular Liquids, 2023, 370, 120923
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Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles

Wei Chen, Chi-An Cheng, Bai-Yu Lee, Daniel L. Clemens, Wen-Yen Huang, Marcus A. Horwitz and Jeffrey I. Zink

ACS Appl. Mater. Interfaces, 2018, 10, 31870
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Synergistic Solvation as the Enhancement of Local Mixing

Seishi Shimizu and Nobuyuki Matubayasi

J. Phys. Chem. B, 2024, 128, 5713
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Cooperative Sorption on Porous Materials

Seishi Shimizu and Nobuyuki Matubayasi

Langmuir, 2021, 37, 10279
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Cholinium-based ionic liquids as bioinspired hydrotropes to tackle solubility challenges in drug formulation

Tânia E. Sintra, Dinis O. Abranches, Jordana Benfica, Bruna P. Soares, Sónia P.M. Ventura and João A.P. Coutinho

European Journal of Pharmaceutics and Biopharmaceutics, 2021, 164, 86
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Ensemble transformation in the fluctuation theory

Seishi Shimizu and Nobuyuki Matubayasi

Physica A: Statistical Mechanics and its Applications, 2022, 585, 126430
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In search for novel functions of adenosine 5′-triphosphate (ATP) in the heart

Thomas Meyer and Niels Voigt

Cardiovascular Research, 2017, 113, e59
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Geminal Diol of Dihydrolevoglucosenone as a Switchable Hydrotrope: A Continuum of Green Nanostructured Solvents

Mario De bruyn, Vitaliy L. Budarin, Antonio Misefari, Seishi Shimizu, Heather Fish, Martin Cockett, Andrew J. Hunt, Heike Hofstetter, Bert M. Weckhuysen, James H. Clark and Duncan J. Macquarrie

ACS Sustainable Chem. Eng., 2019, 7, 7878
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Concentrated Aqueous Sodium Tosylate as Green Medium for Alkene Oxidation and Nucleophilic Substitution Reactions

Tal Sela, Xiaoxi Lin and Arkadi Vigalok

J. Org. Chem., 2017, 82, 11609
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Role of Deep Eutectic Solvent Precursors as Hydrotropes: Unveiling Synergism/Antagonism for Enhanced Kraft Lignin Dissolution

Filipe H. B. Sosa, Dinis O. Abranches, André M. da Costa Lopes, Mariana C. da Costa and João A. P. Coutinho

ACS Sustainable Chem. Eng., 2024, 12, 8930
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Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

Rabindranath Paul, Krishna Gopal Chattaraj and Sandip Paul

Langmuir, 2021, 37, 4745
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Temperature Dependence of Hydrotropy

Seishi Shimizu and Nobuyuki Matubayasi

J. Phys. Chem. B, 2024, 128, 10915
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Kraft Lignin Solubility and Its Chemical Modification in Deep Eutectic Solvents

Filipe H. B. Sosa, Dinis O. Abranches, André M. da Costa Lopes, João A. P. Coutinho and Mariana C. da Costa

ACS Sustainable Chem. Eng., 2020, 8, 18577
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Progress in the field of hydrotropy: mechanism, applications and green concepts

Akash D. Patel and Meghal A. Desai

Reviews in Chemical Engineering, 2023, 39, 601
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A promising hydrotropic effect of Tetra n-octyl ammonium bromide (TOAB) for thermodynamic investigation of surface tension, conductivity of indole in water

Shashikant Shivaji Vhatkar, Kumar Abhisek, Helen Treasa Mathew and Ramesh Oraon

Analytical Chemistry Letters, 2023, 13, 451
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Solubility Enhancement of Hydrophobic Compounds in Aqueous Solutions Using Biobased Solvents as Hydrotropes

Sandra S. Silva, Dinis O. Abranches, Ana S. Pinto, Bruna P. Soares, Helena Passos, Ana M. Ferreira and João A. P. Coutinho

Ind. Eng. Chem. Res., 2023, 62, 12021
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Aggregation Behavior and Thermodynamic Studies of Hydrotropes: A Review

Akash D. Patel and Meghal A. Desai

Tenside Surfactants Detergents, 2020, 57, 192
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Temperature Dependence of Sorption

Seishi Shimizu and Nobuyuki Matubayasi

Langmuir, 2021, 37, 11008
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Hydrotrope-driven facile synthesis of nanosized polyindole and their electrochemical study for supercapacitor application

Shashikant Shivaji Vhatkar, Kumar Abhisek, Helen Treasa Mathew and Ramesh Oraon

Chem. Pap., 2023, 77, 6785
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Shaped Controlled Polyindole Decorated Vanadium Selenide Nanosheets: A Worthy Approach Using Hydrotrope for Asymmetric Supercapacitors

Shashikant Shivaji Vhatkar, Helen Treasa Mathew, Kumar Abhisek and Ramesh Oraon

J Inorg Organomet Polym, 2024, 34, 1822
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Hydrotrope dynamics: unraveling solubility pattern and correlation of benzimidazole using response surface methodology expert system

Arunodhaya Natarajan, Umaiyambika Neduvel Annal, Vasanth Kumar Elakiyaasokan and Nagendra Gandhi Nagarajan

Journal of Dispersion Science and Technology, 2025, 46, 1216
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Solubility Enhancement of Hydrophobic Substances in Water/Cyrene Mixtures: A Computational Study

Dinis O. Abranches, Jordana Benfica, Seishi Shimizu and João A. P. Coutinho

Ind. Eng. Chem. Res., 2020, 59, 18247
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Multiplicativity in Solubility Isotherms

Seishi Shimizu and Nobuyuki Matubayasi

Ind. Eng. Chem. Res., 2025, 64, 833
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Glycerol Ethers as Hydrotropes and Their Use to Enhance the Solubility of Phenolic Acids in Water

Bruna P. Soares, Dinis O. Abranches, Tânia E. Sintra, Alejandro Leal-Duaso, José Ignacio García, Elísabet Pires, Seishi Shimizu, Simão P. Pinho and João A. P. Coutinho

ACS Sustainable Chem. Eng., 2020, 8, 5742
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Data-Centric Development of Lignin Structure–Solubility Relationships in Deep Eutectic Solvents Using Molecular Simulations

Zeynep Sumer and Reid C. Van Lehn

ACS Sustainable Chem. Eng., 2022, 10, 10144
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Sorption: A Statistical Thermodynamic Fluctuation Theory

Seishi Shimizu and Nobuyuki Matubayasi

Langmuir, 2021, 37, 7380
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EXPLORING MODERN TECHNIQUES FOR SOLUBILITY ENHANCEMENT IN DRUG FORMULATIONS

PRIYANKA V. BAGADE, NILESH S. KULKARNI, PRAVIN D. CHAUDHARI, SHASHIKANT N. DHOLE and UJWALA S. DESAI

Int J Curr Pharm Sci, 2025, 31
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Intensive nature of fluctuations: Reconceptualizing Kirkwood-Buff theory via elementary algebra

Seishi Shimizu and Nobuyuki Matubayasi

Journal of Molecular Liquids, 2020, 318, 114225
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Enhanced Solubility of Lignin Monomeric Model Compounds and Technical Lignins in Aqueous Solutions of Deep Eutectic Solvents

Belinda Soares, Daniel J. P. Tavares, José Luis Amaral, Armando J. D. Silvestre, Carmen S. R. Freire and João A. P. Coutinho

ACS Sustainable Chem. Eng., 2017, 5, 4056
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Exploring the role of temperature on hydrotropy

Dinis O. Abranches, Bruna P. Soares, Isabella W. Cordova, Jordana Benfica, Olga Ferreira, Simão P. Pinho and João A.P. Coutinho

Chemical Engineering Science, 2025, 313, 121759
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The Perspective of Cooperative Hydrotropy on the Solubility in Aqueous Solutions of Cyrene

Dinis O. Abranches, Jordana Benfica, Seishi Shimizu and João A. P. Coutinho

Ind. Eng. Chem. Res., 2020, 59, 18649
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Kirkwood-Buff Analysis of Binary and Ternary Systems Consisting of Alcohols (Methanol, Ethanol, 1-Propanol, and 2-Propanol), Water, and n-Hexane to Understand the Formation of Surfactant-Free Microemulsions

Seungmin Seo, Hong-shik Lee and Tae Jun Yoon

J. Phys. Chem. B, 2024, 128, 5092
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Hydrotropy and Cosolvency in Lignin Solubilization with Deep Eutectic Solvents

Belinda Soares, Armando J. D. Silvestre, Paula C. Rodrigues Pinto, Carmen S. R. Freire and João A. P. Coutinho

ACS Sustainable Chem. Eng., 2019
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Amyl Xyloside, a Selective Sugar-Based Hydrotrope for the Aqueous Extraction of Carnosic Acid from Rosemary

Agathe Mazaud, Raphaël Lebeuf, Christel Pierlot, Mickaël Laguerre and Véronique Nardello-Rataj

ACS Sustainable Chem. Eng., 2021, 9, 4801
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Acid Hydrotropic Fractionation of Lignocelluloses for Sustainable Biorefinery: Advantages, Opportunities, and Research Needs

Junyong Zhu, Liheng Chen and Cheng Cai

ChemSusChem, 2021, 14, 3031
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How Sugars Modify Caffeine Self-Association and Solubility: Resolving a Mechanism of Selective Hydrotropy

Ilan Shumilin, Christoph Allolio and Daniel Harries

J. Am. Chem. Soc., 2019, 141, 18056
DOI: 10.1021/jacs.9b07056

Selection of hydrotropes for enhancing the solubility of artemisinin in aqueous solutions

Isabela Sales, Dinis.O. Abranches, Tânia E. Sintra, Silvana Mattedi, Mara G. Freire, João A.P. Coutinho and Simão P. Pinho

Fluid Phase Equilibria, 2022, 562, 113556
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The effect of water content on lignin solubilization in deep eutectic solvents

Yuling Zhang, Hongwei Ren, Hasmerya Maarof, Syarah Mat Udin, Yize Liu, Meiyu Li, Hajar Alias and Erhong Duan

Journal of Molecular Liquids, 2023, 374, 121271
DOI: 10.1016/j.molliq.2023.121271

Drug Solubilization by Means of Partition/Association Equilibrium Using a Modified Nanosized Dendrimeric Biopolymer

Hwee Jing Ong and Rodolfo Pinal

AAPS PharmSciTech, 2019, 20
DOI: 10.1208/s12249-019-1490-0