Nusaybah Alotaibi, Rasool Babaahmadi, Milan Pramanik, Tanja Kaehler, Ayan Dasgupta, Emma Richards, Alireza Ariafard, Thomas Wirth and Rebecca L. Melen

Dalton Trans., 2023, 52, 5039
DOI: 10.1039/D3DT00745F

Chiral-at-metal rhodium(iii) complex catalyzed enantioselective synthesis of C2-substituted benzofuran derivatives

Haoran Zhang, Shiwu Li, Qiang Kang and Yu Du

Org. Chem. Front., 2019, 6, 3683
DOI: 10.1039/C9QO01022J

Atom-economical selenation of electron-rich arenes and phosphonates with molecular oxygen at room temperature

Samir Kumar Bhunia, Pritha Das and Ranjan Jana

Org. Biomol. Chem., 2018, 16, 9243
DOI: 10.1039/C8OB02792G

Asymmetric synthesis of spirooxindole–pyranoindole products via Friedel–Crafts alkylation/cyclization of the indole carbocyclic ring

Yuan Gao, Xiaonan Wang, Zhonglin Wei, Jungang Cao, Dapeng Liang, Yingjie Lin and Haifeng Duan

New J. Chem., 2020, 44, 9788
DOI: 10.1039/D0NJ00074D

Reaction of phosphinylated nitrosoalkenes with electron-rich heterocycles. Electrophilic aromatic substitution vs. cycloaddition

Jesús M. de los Santos, Gloria Rubiales, Zouhair Es Sbai, Ana M. Ochoa de Retana and Francisco Palacios

Org. Biomol. Chem., 2017, 15, 662
DOI: 10.1039/C6OB02486F

Metal-free C(sp3)–H bond functionalization via oxidative cross-dehydrogenative coupling

Jun Xu, Fan Zhang, Minghua Gan, Yaoyao Liu, Mengqi Wang, Jianfeng Wen and Die Hu

Green Chem., 2026, 28, 1904
DOI: 10.1039/D5GC05120G

An asymmetric Brønsted acid-catalyzed Friedel–Crafts reaction of indoles with cyclic N-sulfimines

Sang Gyu Lee and Sung-Gon Kim

RSC Adv., 2017, 7, 34283
DOI: 10.1039/C7RA06244C

Cobalt-catalysed reductive C–H alkylation of indoles using carboxylic acids and molecular hydrogen

Jose R. Cabrero-Antonino, Rosa Adam, Kathrin Junge and Matthias Beller

Chem. Sci., 2017, 8, 6439
DOI: 10.1039/C7SC02117H

Asymmetric dearomative cyclopropanation of naphthalenes to construct polycyclic compounds

Fujun Guan, Rong Zhou, Xiaoyu Ren, Zhen Guo, Chengming Wang and Cong-Ying Zhou

Chem. Sci., 2022, 13, 13015
DOI: 10.1039/D2SC04509E

An overview of the applications of chiral phosphoric acid organocatalysts in enantioselective additions to CO and CN bonds

Xabier del Corte, Edorta Martínez de Marigorta, Francisco Palacios, Javier Vicario and Aitor Maestro

Org. Chem. Front., 2022, 9, 6331
DOI: 10.1039/D2QO01209J

Palladium-catalyzed regioselective C–H alkynylation of indoles with haloalkynes: access to functionalized 7-alkynylindoles

Songjia Fang, Guangbin Jiang, Meng Li, Zhenying Liu, Huanfeng Jiang and Wanqing Wu

Chem. Commun., 2019, 55, 13769
DOI: 10.1039/C9CC07263B

Exploiting the σ-phylic properties of cationic gold(i) catalysts in the ring opening reactions of aziridines with indoles

Elisabetta Rossi, Giorgio Abbiati, Monica Dell'Acqua, Marco Negrato, Andrea Paganoni and Valentina Pirovano

Org. Biomol. Chem., 2016, 14, 6095
DOI: 10.1039/C6OB00672H

Micelle-mediated multicomponent cross-coupling in water: general construction of 3-chalcogenylindoles

Xi He, Weili Song, Xuemin Liu, Jiamin Huang, Ruilong Feng, Shaodong Zhou, Jianquan Hong and Xin Ge

Green Chem., 2023, 25, 1311
DOI: 10.1039/D2GC03694K

Controllable synthesis of pyrido[2,3-b]indol-4-ones or indolo[3,2-b]quinolines via formal intramolecular C(sp2)–H functionalization

Bo Song, Mengdan Wang, Murong Xu, Lingkai Kong, Huihui Xie, Chengyu Wang and Yanzhong Li

Org. Biomol. Chem., 2019, 17, 9960
DOI: 10.1039/C9OB02108F

Asymmetric aza-Friedel–Crafts reaction of newly developed ketimines: access to chiral indeno[1,2-b]quinoxaline architectures

Zhen-Hua Wang, Tong Zhang, Dong-Qun Huang, Jia-Xin Li, Yong You, Lei Yang, Jian-Qiang Zhao, Yan-Ping Zhang and Wei-Cheng Yuan

Org. Biomol. Chem., 2025, 23, 4654
DOI: 10.1039/D5OB00372E

HFIP-mediated three-component imidization of electron-rich arenes with in situ formed spiroindolenines for facile construction of 2-arylspiroindolenines

Chunyan Ge, Liang Wang, Fangzhi Hu, Zhanshuai Ding, Xinyao Li, Deshuai Xiao, Jiayi Wang and Shuai-Shuai Li

Org. Chem. Front., 2022, 9, 1696
DOI: 10.1039/D1QO01862K

Synthesis of C3-functionalized indole derivatives via Brønsted acid-catalyzed regioselective arylation of 2-indolylmethanols with guaiazulene

Yang Liu, Meng Cao, Shangxi Zhang, Zhenxi Wang, Xin Dai, Xinde Jiang, Yucheng Dong and Jie Fu

Org. Biomol. Chem., 2022, 20, 1510
DOI: 10.1039/D1OB02384E

Metal–organic frameworks: advanced tools for multicomponent reactions

Mohammad Ali Ghasemzadeh, Boshra Mirhosseini-Eshkevari, Mona Tavakoli and Farzad Zamani

Green Chem., 2020, 22, 7265
DOI: 10.1039/D0GC01767A

Organocatalytic dimensions to the C–H functionalization of the carbocyclic core in indoles: a review update

Prantika Bhattacharjee and Utpal Bora

Org. Chem. Front., 2021, 8, 2343
DOI: 10.1039/D0QO01466D

C3-Functionalization of indoles with α-heteroaryl-substituted methyl alcohols

Ethan J. Pazur, Nikhil R. Tasker and Peter Wipf

Org. Biomol. Chem., 2023, 21, 8651
DOI: 10.1039/D3OB01432K

Theoretical investigation on the Cu(i)-catalyzed N-carboxamidation of indoles with isocyanates to form indole-1-carboxamides: effects of solvents

Binfang Yuan, Jingwei Wan, Xiaogang Guo, Yongmi Gong, Fulan Zhang, Qing Li, Guangzhao Wang, Jinyang Chen and Rongxing He

New J. Chem., 2020, 44, 9878
DOI: 10.1039/D0NJ01116A

Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions

Peng Liu, Jian-Wu Hao, Li-Ping Mo and Zhan-Hui Zhang

RSC Adv., 2015, 5, 48675
DOI: 10.1039/C5RA05746A

Access to 5H-benzo[a]carbazol-6-ols and benzo[6,7]cyclohepta[1,2-b]indol-6-ols via rhodium-catalyzed C–H activation/carbenoid insertion/aldol-type cyclization

Yumeng Yuan, Xiemin Guo, Xiaofeng Zhang, Buhong Li and Qiufeng Huang

Org. Chem. Front., 2020, 7, 3146
DOI: 10.1039/D0QO00820F

Brønsted acid-catalyzed regioselective reactions of 2-indolylmethanols with cyclic enaminone and anhydride leading to C3-functionalized indole derivatives

Can Li, Hong-Hao Zhang, Tao Fan, Yang Shen, Qiong Wu and Feng Shi

Org. Biomol. Chem., 2016, 14, 6932
DOI: 10.1039/C6OB01282E

Iron(ii)-catalyzed C-2 cyanomethylation of indoles and pyrroles via direct oxidative cross-dehydrogenative coupling with acetonitrile derivatives

Kai Qiao, Dong Zhang, Kai Zhang, Xin Yuan, Ming-Wei Zheng, Tian-Fo Guo, Zheng Fang, Li Wan and Kai Guo

Org. Chem. Front., 2018, 5, 1129
DOI: 10.1039/C7QO01086A

Construction of bridged polycycles through dearomatization strategies

Ziying Zhang, Huabin Han, Lele Wang, Zhanwei Bu, Yan Xie and Qilin Wang

Org. Biomol. Chem., 2021, 19, 3960
DOI: 10.1039/D1OB00096A

Manganese catalyzed cross-coupling of allylic alcohols and indoles: an elegant route for access to γ-hydroxyindole

Yanyan Shen, Fangyuan Hu, Yuhua Chen, Dingguo Song, Fei Ling and Weihui Zhong

RSC Adv., 2025, 15, 30622
DOI: 10.1039/D5RA04342E

Asymmetric N-aminoalkylation of 3-substituted indoles by N-protected N,O-acetals: an access to chiral propargyl aminals

Junxian Yang, Zeyuan He, Liang Hong, Wangsheng Sun and Rui Wang

Org. Biomol. Chem., 2020, 18, 4169
DOI: 10.1039/D0OB00795A

Synthesis of azepane-fused pyrano[3,2-b]indoles by Lewis acid-catalysed oxa Diels–Alder reactions

Saikumar Banda, Alexander Villinger and Malte Brasholz

Org. Biomol. Chem., 2023, 21, 4379
DOI: 10.1039/D3OB00234A

Synthesis of 3-indolyl all-carbon quaternary centers via Rh/Brønsted acid co-catalyzed three-component reactions of azoalkenes with indoles and diazoacetates

Xiao-Jing Yue, Li-Ping Pei, Min-Can Wang, Shi-Kun Jia and Guang-Jian Mei

Org. Biomol. Chem., 2025, 23, 5323
DOI: 10.1039/D5OB00567A

Tryptophol and derivatives: natural occurrence and applications to the synthesis of bioactive compounds

Alessandro Palmieri and Marino Petrini

Nat. Prod. Rep., 2019, 36, 490
DOI: 10.1039/C8NP00032H

Tris(trimethylsilyl)silane and visible-light irradiation: a new metal- and additive-free photochemical process for the synthesis of indoles and oxindoles

Gustavo Piva da Silva, Akbar Ali, Rodrigo César da Silva, Hao Jiang and Márcio W. Paixão

Chem. Commun., 2015, 51, 15110
DOI: 10.1039/C5CC06329A

Diversity-oriented synthesis of indole-fused scaffolds and bis(indolyl)methane from tosyl-protected tryptamine

Liang Wang, Xiaopei Song, Fengxia Guo, Lubin Xu, Fangzhi Hu, Feng-Wei Guo and Shuai-Shuai Li

Org. Biomol. Chem., 2024, 22, 2824
DOI: 10.1039/D4OB00099D

The mechanism of [3+2] annulations between indole-2-formaldehydes and isatins mediated by N-hetrocyclic carbenes: a DFT study

Yan Li, Mingchao Zhang, Lina Geng and Zhiqiang Zhang

New J. Chem., 2022, 46, 22746
DOI: 10.1039/D2NJ04442K

Catalyst and solvent switched divergent C–H functionalization: oxidative annulation of N-aryl substituted quinazolin-4-amine with alkynes

Siddi Ramulu Meesa, Praveen Kumar Naikawadi, Kishan Gugulothu and K. Shiva Kumar

Org. Biomol. Chem., 2020, 18, 3032
DOI: 10.1039/D0OB00318B

Advances in organocatalytic asymmetric reactions of vinylindoles: powerful access to enantioenriched indole derivatives

Man-Su Tu, Ke-Wei Chen, Ping Wu, Yu-Chen Zhang, Xiao-Qin Liu and Feng Shi

Org. Chem. Front., 2021, 8, 2643
DOI: 10.1039/D0QO01643H

Copper–iodine co-catalyzed C–H aminoalkenylation of indoles via temperature-controlled selectivity switch: facile synthesis of 2-azolyl-3-alkenylindoles

Xiaoxiang Zhang, Wenhua Yu, Yiyu Nie, Yingying Zhang, Xiaoting Gu, Wanxing Wei, Zhuan Zhang and Taoyuan Liang

Org. Chem. Front., 2022, 9, 3794
DOI: 10.1039/D2QO00627H

Direct construction of benzimidazo[l,2-c]quinazolin-6-onesviametal-free oxidative C–C bond cleavage

Ping-Gui Li, Cheng Yan, Shuai Zhu, Shu-Hui Liu and Liang-Hua Zou

Org. Chem. Front., 2018, 5, 3464
DOI: 10.1039/C8QO01039K

Chiral cis-iron(ii) complexes with metal- and ligand-centered chirality for highly regio- and enantioselective alkylation of N-heteroaromatics

Jinhu Wei, Bei Cao, Chun-Wai Tse, Xiao-Yong Chang, Cong-Ying Zhou and Chi-Ming Che

Chem. Sci., 2020, 11, 684
DOI: 10.1039/C9SC04858H

Synthesis of spiro isoindolinone-indolines and 1,2-disubstituted indoles from 2-iodobenzamide derivatives

Bharath Kumar Villuri, Trimurtulu Kotipalli, Veerababurao kavala, Sachin S. Ichake, Vijayalakshmi Bandi, Chun-Wei Kuo and Ching-Fa Yao

RSC Adv., 2016, 6, 74845
DOI: 10.1039/C6RA15002K

New achievements on C-C bond formation in water catalyzed by metal complexes

Franco Scalambra, Pablo Lorenzo-Luis, Isaac de los Rios and Antonio Romerosa

Coordination Chemistry Reviews, 2021, 443, 213997
DOI: 10.1016/j.ccr.2021.213997

Sulfamic Acid‐Catalyzed One‐Pot Synthesis of a New Series of Biologically Relevant Indole‐Uracil Molecular Hybrids in Water at Room Temperature

Goutam Brahmachari, Sanchari Begam and Khondekar Nurjamal

ChemistrySelect, 2018, 3, 3400
DOI: 10.1002/slct.201800488

An Arylation Strategy to Propargylamines: Catalytic Asymmetric Friedel–Crafts‐type Arylation Reactions of C‐Alkynyl Imines

Yingcheng Wang, Liang Jiang, Long Li, Jun Dai, Dan Xiong and Zhihui Shao

Angew Chem Int Ed, 2016, 55, 15142
DOI: 10.1002/anie.201608918

Carbene‐Catalyzed Enantioselective Aromatic N‐Nucleophilic Addition of Heteroarenes to Ketones

Yonggui Liu, Guoyong Luo, Xing Yang, Shichun Jiang, Wei Xue, Yonggui Robin Chi and Zhichao Jin

Angewandte Chemie, 2020, 132, 450
DOI: 10.1002/ange.201912160

Construction of pyrrole- and indole-fused CF3-piperazine derivatives

Yu-Ting Tian, Yu-Wei Zong, Jing Nie, Fa-Guang Zhang and Jun-An Ma

Journal of Fluorine Chemistry, 2019, 226, 109361
DOI: 10.1016/j.jfluchem.2019.109361

Enantioselective Formal [4+2] Cycloadditions to 3‐Nitroindoles by Trienamine Catalysis: Synthesis of Chiral Dihydrocarbazoles

Yang Li, Fernando Tur, Rune Pagh Nielsen, Hao Jiang, Frank Jensen and Karl Anker Jørgensen

Angew Chem Int Ed, 2016, 55, 1020
DOI: 10.1002/anie.201509693

High‐Pressure‐Mediated Asymmetric Organocatalytic Hydroxyalkylation of Indoles with Trifluoromethyl Ketones

Adrian Kasztelan, Michał Biedrzycki and Piotr Kwiatkowski

Adv Synth Catal, 2016, 358, 2962
DOI: 10.1002/adsc.201600327

Catalytic Enantioselective Arylative Dearomatization of 3‐Methyl‐2‐vinylindoles Enabled by Reactivity Switch

Yang Wang, Meng Sun, Lei Yin and Feng Shi

Adv Synth Catal, 2015, 357, 4031
DOI: 10.1002/adsc.201500901

Development of the Vinylogous Pictet–Spengler Cyclization and Total Synthesis of (±)‐Lundurine A

Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens and Uttam K. Tambar

Angewandte Chemie, 2018, 130, 7004
DOI: 10.1002/ange.201803702

Synthesis of Polysubstituted Cyclopentene and Cyclopenta[b]carbazole Analogues from Unsymmetrical 4-Arylidene-3,6-diarylhex-2-en-5-ynal and Indole Derivatives via an Iodine Mediated Electrocyclization Reaction

Vijayalakshmi Bandi, Veerababurao Kavala, Ashok Konala, Che-Hao Hsu, Bharath Kumar Villuri, Sabbasani Rajasekhara Reddy, LiChun Lin, Chun-Wei Kuo and Ching-Fa Yao

J. Org. Chem., 2019, 84, 3036
DOI: 10.1021/acs.joc.8b02168

Tandem Annulations of Propargylic Alcohols to Indole Derivatives

Xiao‐Yan Liu, Yun‐Lin Liu and Long Chen

Adv Synth Catal, 2020, 362, 5170
DOI: 10.1002/adsc.202000930

Iodine-Catalyzed C–H Amidation and Imination at the 2α-Position of 2,3-Disubstituted Indoles with Chloramine Salts

Xiaozu Liu, Yuxiang Zhou, Zhongqin Yang, Qin Li, Liang Zhao and Peijun Liu

J. Org. Chem., 2018, 83, 4665
DOI: 10.1021/acs.joc.8b00286

Arylation of N‐Methyl‐2‐oxindole with Arylboronic Acids in Water Catalyzed by Palladium(II) Pincer Complexes with a Low Catalyst Loading

Arumugam Vignesh, Werner Kaminsky and Nallasamy Dharmaraj

ChemCatChem, 2017, 9, 910
DOI: 10.1002/cctc.201601411

Highly Enantioselective Synthesis of Pyrroloindolones and Pyrroloquinolinones via an N-Heterocyclic Carbene-Catalyzed Cascade Reaction

Xiao-Yong Duan, Zhaohui Tian, Binghao Liu, Tao He, Liang-Liang Zhao, Mengdie Dong, Pengna Zhang and Jing Qi

Org. Lett., 2021, 23, 3777
DOI: 10.1021/acs.orglett.1c01203

Organocatalytic Enantioselective Friedel–Crafts Alkylation of 1‐Naphthol Derivatives and Activated Phenols with Ethyl Trifluoropyruvate

Marc Montesinos‐Magraner, Carlos Vila, Gonzalo Blay, Isabel Fernández, M. Carmen Muñoz and José R. Pedro

Adv Synth Catal, 2015, 357, 3047
DOI: 10.1002/adsc.201500548

Catalyst-Free Conjugate Addition of Indolizines to In Situ-Generated Oxidized Morita–Baylis–Hillman Adducts

Thiago S. Silva, Lucas A. Zeoly and Fernando Coelho

J. Org. Chem., 2020, 85, 5438
DOI: 10.1021/acs.joc.0c00189

Asymmetric Dearomatization of Nonfunctionalized 1-Naphthols via Copper-Catalyzed Enantioselective [4 + 1] Spiroannulation

Xingguang Li, Jia-Xing Guo, Jin Zhang, Qian-Yu Chen, Yu-Jie He, Feng Sha, Huijing Xiang, Peiyuan Yu and Pei-Nian Liu

ACS Catal., 2024, 14, 9244
DOI: 10.1021/acscatal.4c01563

Asymmetric Dearomatization of 3H-Indoles via Copper-Catalyzed Enantioselective [4 + 1] Spiroannulation with Vinyl Ethynylethylene Carbonates

Jiaxing Guo, Yujie He, Xuan Cheng, Huijing Xiang and Xingguang Li

Org. Lett., 2025, 27, 10700
DOI: 10.1021/acs.orglett.5c03214

Thiourea‐Catalyzed Addition of Indoles to Aliphatic β,γ‐Unsaturated α‐Ketoesters

Verónica Juste‐Navarro, Eugenia Marqués‐López and Raquel P. Herrera

Asian J Org Chem, 2015, 4, 884
DOI: 10.1002/ajoc.201500154

Lipase‐Catalyzed Kinetic Resolution of N‐Substituted 1‐(β‐Hydroxypropyl)indoles by Enantioselective Acetylation

Paweł Borowiecki, Maciej Dranka and Zbigniew Ochal

Eur J Org Chem, 2017, 2017, 5378
DOI: 10.1002/ejoc.201700889

A novel Pd-catalysed sequential carbonylation/cyclization approach toward bis- N -heterocycles: rationalization by electronic structure calculations

Liliana Damas, Rui M. B. Carrilho, Sandra C. C. Nunes, Alberto A. C. C. Pais, László Kollár, Marta Pineiro and Mariette M. Pereira

R. Soc. open sci., 2018, 5, 181140
DOI: 10.1098/rsos.181140

Brønsted Acid Catalyzed [3+2]‐Cycloaddition of 2‐Vinylindoles with In Situ Generated 2‐Methide‐2H‐indoles: Highly Enantioselective Synthesis of Pyrrolo[1,2‐a]indoles

Kalisankar Bera and Christoph Schneider

Chemistry A European J, 2016, 22, 7074
DOI: 10.1002/chem.201601020

A Cascade Approach for the Synthesis of 5-(Indol-3-yl)hydantoin: An Application to the Total Synthesis of (±)-Oxoaplysinopsin B

Ponnusamy Pon Sathieshkumar, Metlapalli Durga Anand Saibabu and Rajagopal Nagarajan

J. Org. Chem., 2021, 86, 3730
DOI: 10.1021/acs.joc.0c02435

Synthesis of 3‐Substituted Chalcogenophene‐Fused Indoles from 2‐Alkynylindoles

Guilherme Leonel, Davi F. Back and Gilson Zeni

Adv Synth Catal, 2020, 362, 585
DOI: 10.1002/adsc.201901213

An Efficient Approach to Aromatic Aminomethylation Using Dichloromethane as Methylene Source

Carmine Ostacolo, Veronica Di Sarno, Simona Musella, Tania Ciaglia, Vincenzo Vestuto, Giacomo Pepe, Fabrizio Merciai, Pietro Campiglia, Isabel M. Gomez Monterrey and Alessia Bertamino

Front. Chem., 2019, 7
DOI: 10.3389/fchem.2019.00568

Design and Enantioselective Construction of Axially Chiral Naphthyl‐Indole Skeletons

Hong‐Hao Zhang, Cong‐Shuai Wang, Can Li, Guang‐Jian Mei, Yuxue Li and Feng Shi

Angew Chem Int Ed, 2017, 56, 116
DOI: 10.1002/anie.201608150

Transition Metal‐Free P‐Se Oxidative Cross‐Coupling for the Synthesis of Phosphoroselenothioates and Phosphoroselenoates

Sung‐Hung Lee, Indrajit Karmakar, Hsiu‐Te Hung, Rekha Bai, Chin Chang, Mi‐Zuo Huang, Kuan‐Yu Lin and Chin‐Fa Lee

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.70223

The Diverse Reactivity of Homopropargylic Amines as “Masked” 1C Synthons for the Aza‐Friedel–Crafts Alkylation of Indoles

Hao Chen, Min Ni, Xiaofeng Bao, Chan Wang, Lingyan Liu, Weixing Chang and Jing Li

Eur J Org Chem, 2018, 2018, 470
DOI: 10.1002/ejoc.201701523

Asymmetric Phosphoric Acid‐catalyzed Aza‐Friedel–Crafts Reaction of Furan with Cyclic N‐Sulfimines

Jiseon Lee and Sung‐Gon Kim

Bulletin Korean Chem Soc, 2019, 40, 606
DOI: 10.1002/bkcs.11731

Fe(III)-Catalyzed direct C3 chalcogenylation of indole: The effect of iodide ions

Eduardo Q. Luz, Diego Seckler, Janylson Souza Araújo, Leonardo Angst, David B. Lima, Elise Ane Maluf Rios, Ronny R. Ribeiro and Daniel S. Rampon

Tetrahedron, 2019, 75, 1258
DOI: 10.1016/j.tet.2019.01.037

Discovery and enantiocontrol of axially chiral urazoles via organocatalytic tyrosine click reaction

Ji-Wei Zhang, Jin-Hui Xu, Dao-Juan Cheng, Chuan Shi, Xin-Yuan Liu and Bin Tan

Nat Commun, 2016, 7
DOI: 10.1038/ncomms10677

Organocatalytic Enantioselective Functionalization of Unactivated Indole C(sp3)−H Bonds

Dengke Ma, Zhihan Zhang, Min Chen, Zhenyang Lin and Jianwei Sun

Angewandte Chemie, 2019, 131, 16063
DOI: 10.1002/ange.201909397

Catalytic Asymmetric Synthesis of Chiral Bis(indolyl)methanes Using a Ts-PyBidine–Nickel Complex

Ryo Sato, Takuya Tosaka, Hyuma Masu and Takayoshi Arai

J. Org. Chem., 2019, 84, 14248
DOI: 10.1021/acs.joc.9b02006

Synthesis of 3-Substituted Indoles by Yonemitsu Three-Component Reactions Accelerated in Microdroplet/Thin Film

Yikang Wu, Jiayao Li, Jiannan Sun, Yizhou Wang, Jinhua Liu and Heyong Cheng

J. Org. Chem., 2024, 89, 18493
DOI: 10.1021/acs.joc.4c02395

Gold-catalyzed Bicyclization of Diaryl Alkynes: Synthesis of Polycyclic Fused Indole and Spirooxindole Derivatives

Ju Cai, Bing Wu, Guangwei Rong, Cheng Zhang, Lihua Qiu and Xinfang Xu

Org. Lett., 2018, 20, 2733
DOI: 10.1021/acs.orglett.8b00939

Efficient assembly and anti-tumor evaluation of novel polycyclic [1,2-a]-fused indoles

Hui Guo, Yuqi Tian, Xing Wu, Liang Tu, Jikai Liu, Yongsheng Zheng and Rong Huang

Bioorganic Chemistry, 2024, 146, 107289
DOI: 10.1016/j.bioorg.2024.107289

Approach to preparative synthesis of ortho-(1-methylbut-2-en-1-yl)anilines, precursors of new cytotoxic heterocycles

L. A. Aleksandrova, M. F. Abdullin, Yu. V. Vakhitova and R. R. Gataullin

Russ J Gen Chem, 2016, 86, 810
DOI: 10.1134/S1070363216040083

Carbene-Catalyzed Indole 3-Methyl C(sp3)–H Bond Functionalization

Jian Cheng, Jun Sun, Jiekuan Yan, Song Yang, Pengcheng Zheng, Zhichao Jin and Yonggui Robin Chi

J. Org. Chem., 2017, 82, 13342
DOI: 10.1021/acs.joc.7b02436

Asymmetric Hydrogenative Coupling of Indoles with Unsaturated Ketones Enabled by Copper/Ruthenium Relay Catalysis

Jian Zhang, Chen Guo, Weijun Tang, Dong Xue, Huaming Sun, Jianliang Xiao and Chao Wang

Synthesis, 2024, 56, 3390
DOI: 10.1055/a-2295-5417

Solvent-controlled and selective synthesis of mono- and bis-indolyl products in Brønsted acid catalyzed aza-Friedel–Crafts reactions of indoles with cyclic imines

You-Qing Wang, Zhong-Shu Wei, Chao-Qun Zhu, Yuan-Yuan Ren and Chunrui Wu

Tetrahedron, 2016, 72, 4643
DOI: 10.1016/j.tet.2016.06.037

Thermal and spectroscopic studies of 2,3,5-trisubstituted and 1,2,3,5-tetrasubstituted indoles as non-competitive antagonists of GluK1/GluK2 receptors

Agata Bartyzel, Agnieszka A. Kaczor, Halina Głuchowska, Monika Pitucha, Tomasz M. Wróbel and Dariusz Matosiuk

J Therm Anal Calorim, 2018, 133, 935
DOI: 10.1007/s10973-018-7146-6

Rhodium(III)‐Catalyzed Regioselective C−H Allylation and Prenylation of Indoles at C4‐Position

Shang‐Shi Zhang, Yan‐Zhi Liu, Yi‐Chuan Zheng, Hui Xie, Shao‐Yong Chen, Jia‐Lin Song and Bing Shu

Adv Synth Catal, 2022, 364, 64
DOI: 10.1002/adsc.202100882

Tandem Cross‐Coupling/Spirocyclization/Mannich‐Type Reactions of 3‐(2‐Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines

Guo‐Shu Chen, Shu‐Jie Chen, Jian Luo, Xiang‐Yu Mao, Albert Sun‐Chi Chan, Raymond Wai‐Yin Sun and Yun‐Lin Liu

Angewandte Chemie, 2020, 132, 624
DOI: 10.1002/ange.201911614

The Application of N‐Protected 3‐Vinylindoles in Chiral Phosphoric Acid‐Catalyzed [3+2] Cyclization with 3‐Indolylmethanols: Monoactivation of the Catalyst to Vinyliminium

Tao Fan, Hong‐Hao Zhang, Can Li, Yang Shen and Feng Shi

Adv Synth Catal, 2016, 358, 2017
DOI: 10.1002/adsc.201501175

Organocatalytic Enantioselective Friedel–Crafts Alkylation/Lactonization Reaction of Hydroxyindoles with Methyleneoxindoles

Mengjie Xiao, Dengfeng Xu, Weihong Liang, Wenyu Wu, Albert S. C. Chan and Junling Zhao

Adv Synth Catal, 2018, 360, 917
DOI: 10.1002/adsc.201701089

Enantioselective Formal [4+2] Cycloadditions to 3‐Nitroindoles by Trienamine Catalysis: Synthesis of Chiral Dihydrocarbazoles

Yang Li, Fernando Tur, Rune Pagh Nielsen, Hao Jiang, Frank Jensen and Karl Anker Jørgensen

Angewandte Chemie, 2016, 128, 1032
DOI: 10.1002/ange.201509693

Organocatalytic Enantioselective Synthesis of Chiral Allenes: Remote Asymmetric 1,8‐Addition of Indole Imine Methides

Xingguang Li and Jianwei Sun

Angew Chem Int Ed, 2020, 59, 17049
DOI: 10.1002/anie.202006137

Development of the Vinylogous Pictet–Spengler Cyclization and Total Synthesis of (±)‐Lundurine A

Aaron Nash, Xiangbing Qi, Pradip Maity, Kyle Owens and Uttam K. Tambar

Angew Chem Int Ed, 2018, 57, 6888
DOI: 10.1002/anie.201803702

Asymmetric N-Hydroxyalkylation of Indoles with Ethyl Glyoxalates Catalyzed by a Chiral Phosphoric Acid: Highly Enantioselective Synthesis of Chiral N,O-Aminal Indole Derivatives

Le Wang, Jia Zhou, Tong-Mei Ding, Zhi-Qiang Yan, Si-Hua Hou, Guo-Dong Zhu and Shu-Yu Zhang

Org. Lett., 2019, 21, 2795
DOI: 10.1021/acs.orglett.9b00757

Cu(OTf)2 and a novel axially chiral quinoline-arylphenol ligand partner enabled an enantioselective C H functionalization of indoles with vinylogous migratory carbene insertion of α-arylidene diazosuccinimides for stout preparation of chiral maleimides

Chun-Jun Zhu, Qian-Mao Zhang, Hao Fan, Xiao Fu, Chun-Chun Tang, Wen-Juan Wan, Fang Tian and Li-Xin Wang

Tetrahedron Letters, 2025, 167, 155662
DOI: 10.1016/j.tetlet.2025.155662

Enantioselective synthesis of indoles through catalytic indolization

Bin-Miao Yang, Xiao Qian Ng and Yu Zhao

Chem Catalysis, 2022, 2, 3048
DOI: 10.1016/j.checat.2022.10.004

Organocatalytic Regio- and Enantioselective Allylic Alkylation of Indolin-2-imines with MBH Carbonates toward 3-Allylindoles

Lunfeng Chen and Pengfei Li

J. Org. Chem., 2023, 88, 7810
DOI: 10.1021/acs.joc.2c02310

Rhodium(I)‐Catalyzed C2‐Selective Decarbonylative C−H Alkylation of Indoles with Alkyl Carboxylic Acids and Anhydrides

Haiyang Yu, Haoqiang Zhao, Xin Xu, Xin Zhang, Zexin Yu, Lingchao Li, Peng Wang, Qian Shi and Lijin Xu

Asian J Org Chem, 2021, 10, 879
DOI: 10.1002/ajoc.202000712

Tandem Cross‐Coupling/Spirocyclization/Mannich‐Type Reactions of 3‐(2‐Isocyanoethyl)indoles with Diazo Compounds toward Polycyclic Spiroindolines

Guo‐Shu Chen, Shu‐Jie Chen, Jian Luo, Xiang‐Yu Mao, Albert Sun‐Chi Chan, Raymond Wai‐Yin Sun and Yun‐Lin Liu

Angew Chem Int Ed, 2020, 59, 614
DOI: 10.1002/anie.201911614

Catalytic Asymmetric [3 + 2] Annulation via Indolyl Copper–Allenylidene Intermediates: Diastereo- and Enantioselective Assembly of Pyrrolo[1,2-a]indoles

Jian Zhang, Tao Ni, Wu-Lin Yang and Wei-Ping Deng

Org. Lett., 2020, 22, 4547
DOI: 10.1021/acs.orglett.0c01594

Brønsted Acid-Catalyzed Tandem Double Friedel–Crafts Alkylation to Construct a Dihydrophenalene Skeleton Bearing an All-Carbon Quaternary Center

Mingjing OuYang, Min Yuan, Jinwei Li and Wen Yang

J. Org. Chem., 2024, 89, 576
DOI: 10.1021/acs.joc.3c02310

Metal‐Templated Asymmetric Catalysis: (Z)‐1‐Bromo‐1‐Nitrostyrenes as Versatile Substrates for Friedel–Crafts Alkylation of Indoles

Kaifang Huang, Qiao Ma, Xiang Shen, Lei Gong and Eric Meggers

Asian J Org Chem, 2016, 5, 1198
DOI: 10.1002/ajoc.201600288

Chiral Imidodiphosphoric Acids‐Catalyzed Friedel–Crafts Reactions of Indoles/Pyrroles with 3‐Hydroxy‐indolyloxindoles: Enantioselective Synthesis of 3,3‐Diaryloxindoles

Ming‐Hua Zhuo, Guo‐Feng Liu, Shan‐Liang Song, Dong An, Jigang Gao, Liangyu Zheng and Suoqin Zhang

Adv Synth Catal, 2016, 358, 808
DOI: 10.1002/adsc.201500985

Design and Enantioselective Construction of Axially Chiral Naphthyl‐Indole Skeletons

Hong‐Hao Zhang, Cong‐Shuai Wang, Can Li, Guang‐Jian Mei, Yuxue Li and Feng Shi

Angewandte Chemie, 2017, 129, 122
DOI: 10.1002/ange.201608150

High‐Pressure Accelerated Enantioselective Addition of Indoles to Trifluoromethyl Ketones with a Low Loading of Chiral BINOL‐Derived Phosphoric Acid

Michał Biedrzycki, Adrian Kasztelan and Piotr Kwiatkowski

ChemCatChem, 2017, 9, 2453
DOI: 10.1002/cctc.201700281

Asymmetric Organocatalyzed Friedel–Crafts Reaction of Trihaloacetaldehydes and Phenols

David Svestka, Jan Otevrel and Pavel Bobal

Adv Synth Catal, 2022, 364, 2174
DOI: 10.1002/adsc.202200180

Weak Chelation-Assisted C4-Selective Alkylation of Indoles with Cyclopropanols via Sequential C–H/C–C Bond Activation

Tripti Paul, Shubhajit Basak and Tharmalingam Punniyamurthy

Org. Lett., 2022, 24, 6000
DOI: 10.1021/acs.orglett.2c02265

Organocatalytic asymmetric synthesis of dihydrocarbazoles via a formal [4+2] cycloaddition of in situ generated o-quinodimethanes with enals

Bo-Qi Gu, Hao Zhang, Ruo-Heng Su and Wei-Ping Deng

Tetrahedron, 2016, 72, 6595
DOI: 10.1016/j.tet.2016.08.077

Enantioselective Synthesis of 3‐Allylindoles from Indolin‐2‐imines and MBH Carbonates via Nucleophilic Catalysis

Lunfeng Chen and Pengfei Li

ChemistrySelect, 2024, 9
DOI: 10.1002/slct.202304866

A Brønsted‐Acidic Ionic Liquid Gel as an Efficient and Recyclable Heterogeneous Catalyst for the Synthesis of Bis(indolyl)methanes under Solvent‐Free Sonication

Phuong Hoang Tran, Xuan‐Trang Thi Nguyen and Duy‐Khiem Nguyen Chau

Asian J Org Chem, 2018, 7, 232
DOI: 10.1002/ajoc.201700596

Syntheses of N-Alkyl 2-Arylindoles from Saturated Ketones and 2-Arylethynylanilines via Cu-Catalyzed Sequential Dehydrogenation/Aza-Michael Addition/Annulation Cascade

Fei Ling, Dingguo Song, Linlin Chen, Tao Liu, Mengyao Yu, Yan Ma, Lian Xiao, Min Xu and Weihui Zhong

J. Org. Chem., 2020, 85, 3224
DOI: 10.1021/acs.joc.9b03091

Organocatalytic Enantioselective aza‐Friedel‐Crafts Reactions of Pyrazolinone Ketimines with Hydroxyindoles and Electron‐Rich Phenols

Zhong‐Tao Yang, Wu‐Lin Yang, Long Chen, Hao Sun and Wei‐Ping Deng

Adv Synth Catal, 2018, 360, 2049
DOI: 10.1002/adsc.201800181

Enantioselective α-Aminophosphonate Functionalization of Indole Ring through an Organocatalyzed Friedel–Crafts Reaction

Aitor Maestro, Edorta Martinez de Marigorta, Francisco Palacios and Javier Vicario

J. Org. Chem., 2019, 84, 1094
DOI: 10.1021/acs.joc.8b02843

Carbene‐Catalyzed Enantioselective Aromatic N‐Nucleophilic Addition of Heteroarenes to Ketones

Yonggui Liu, Guoyong Luo, Xing Yang, Shichun Jiang, Wei Xue, Yonggui Robin Chi and Zhichao Jin

Angew Chem Int Ed, 2020, 59, 442
DOI: 10.1002/anie.201912160

Organo‐Catalyzed Enantioselective [4+2] Annulation of Glutaraldehyde and C3‐Indolyl‐imines To Access Indol‐3‐yl‐piperidines

Anoop Singh, Imtiaz A. Shah, Jyothi Yadav, Preetika Sharma, Rajni Kant, Eldhose Iype, Sravendra Rana and Indresh Kumar

Eur J Org Chem, 2023, 26
DOI: 10.1002/ejoc.202300901

3‐Mono‐Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts‐Type Alkylation of N‐Unprotected α‐Ketiminoester

Ryohei Yonesaki, Yuta Kondo, Walaa Akkad, Masanao Sawa, Kazuhiro Morisaki, Hiroyuki Morimoto and Takashi Ohshima

Chemistry A European J, 2018, 24, 15211
DOI: 10.1002/chem.201804078

Carbene-catalyzed asymmetric Friedel–Crafts alkylation-annulation sequence and rapid synthesis of indole-fused polycyclic alkaloids

Muhammad Anwar, Shuang Yang, Weici Xu, Jinggong Liu, Saima Perveen, Xiangwen Kong, Syeda Tazeen Zehra and Xinqiang Fang

Commun Chem, 2019, 2
DOI: 10.1038/s42004-019-0188-2

Enantioselective Organocatalytic Michael Addition to Unsaturated Indolyl Ketones

Dmitri Trubitsõn, Jevgenija Martõnova, Marina Kudrjašova, Kristin Erkman, Ivar Järving and Tõnis Kanger

Org. Lett., 2021, 23, 1820
DOI: 10.1021/acs.orglett.1c00222

Highly Diastereoselective Synthesis of Polycyclic Indolines through Formal [4+2] Propargylic Cycloaddition of Indoles with Ethynyl Benzoxazinanones

Wen Shao, Qing‐Feng Xu‐Xu and Shu‐Li You

Chemistry An Asian Journal, 2020, 15, 2462
DOI: 10.1002/asia.202000640

NH4I-catalyzed chalcogen(S/Se)-functionalization of 5-membered N-heteroaryls under metal-free conditions

Luana Bettanin, Sumbal Saba, Carlos V. Doerner, Marcelo S. Franco, Marcelo Godoi, Jamal Rafique and Antonio L. Braga

Tetrahedron, 2018, 74, 3971
DOI: 10.1016/j.tet.2018.05.084

Recent advances in catalyst-free photochemical reactions via electron-donor-acceptor (EDA) complex process

Yan-qin Yuan, Swarup Majumder, Ming-hua Yang and Sheng-rong Guo

Tetrahedron Letters, 2020, 61, 151506
DOI: 10.1016/j.tetlet.2019.151506

Brønsted Acid Catalyzed [3 + 2]-Cycloaddition of Cyclic Enamides with in Situ Generated 2-Methide-2H-indoles: Enantioselective Synthesis of Indolo[1,2-a]indoles

Kalisankar Bera and Christoph Schneider

Org. Lett., 2016, 18, 5660
DOI: 10.1021/acs.orglett.6b02898

Enantioselective Friedel–Crafts Reaction for the Synthesis of 4,7-Difunctionalized Indoles Featuring a Chiral Heteroatom-Substituted Quaternary Carbon at the C7 Position

Xiao-Yu Zhong, Xi-Sha Xue, Qiao-Qiao Peng, Juan Liao, Lei Yang, Yan-Ping Zhang, Zhen-Hua Wang, Yong You, Wei-Cheng Yuan and Jian-Qiang Zhao

J. Org. Chem., 2025, 90, 6511
DOI: 10.1021/acs.joc.5c00387

Urea Derivative Catalyzed Enantioselective Hydroxyalkylation of Hydroxyindoles with Isatins

Hao Wu, Liming Wang, Junwei Zhang and Ying Jin

Molecules, 2019, 24, 3944
DOI: 10.3390/molecules24213944

Organocatalytic Enantioselective Synthesis of Chiral Allenes: Remote Asymmetric 1,8‐Addition of Indole Imine Methides

Xingguang Li and Jianwei Sun

Angewandte Chemie, 2020, 132, 17197
DOI: 10.1002/ange.202006137

Synthesis of Spiro[piperidine‐3,3′‐oxindoles] via Gold(I)‐Catalyzed Dearomatization of N‐Propargyl‐ and N‐Homoallenyl‐2‐bromotryptamines

Valentin Magné, Florent Blanchard, Angela Marinetti, Arnaud Voituriez and Xavier Guinchard

Adv Synth Catal, 2016, 358, 3355
DOI: 10.1002/adsc.201600398

Metal‐Catalyzed Synthesis of Substituted Indoles

So Won Youn and Tae Yun Ko

Asian J Org Chem, 2018, 7, 1467
DOI: 10.1002/ajoc.201800290

The Chiral Pool in the Pictet–Spengler Reaction for the Synthesis of β-Carbolines

Renato Dalpozzo

Molecules, 2016, 21, 699
DOI: 10.3390/molecules21060699

Catalytic Enantioselective and Regioselective [3+3] Cycloadditions Using 2‐Indolylmethanols as 3 C Building Blocks

Xiao‐Xue Sun, Hong‐Hao Zhang, Guo‐Hao Li, Ying‐Ying He and Feng Shi

Chemistry A European J, 2016, 22, 17526
DOI: 10.1002/chem.201603049

Asymmetric Synthesis of Indolyl C—N Atropoisomers through Enantioselective Electrophilic Amination

Wei Liu and Xiaoyu Yang

Chinese Journal of Organic Chemistry, 2022, 42, 2596
DOI: 10.6023/cjoc202200042

Friedel–Crafts Alkylation of Indoles with p-Quinols: The Role of Hydrogen Bonding of Water for the Desymmetrization of the Cyclohexadienone System

Carolina García-García, Laura Ortiz-Rojano, Susana Álvarez, Rosana Álvarez, María Ribagorda and M. Carmen Carreño

Org. Lett., 2016, 18, 2224
DOI: 10.1021/acs.orglett.6b00781

Annulation of Indole-2-Carboxamides with Bicycloalkenes Catalyzed by Ru(II) at Room Temperature: An Easy Access to β-Carboline-1-one Derivatives under Mild Conditions

Gopal Krushna Das Adhikari, Smruti Ranjan Mohanty, Shyam Kumar Banjare, Namrata Prusty, Gajiram Murmu and Ponneri C. Ravikumar

J. Org. Chem., 2023, 88, 952
DOI: 10.1021/acs.joc.2c02351

Iridium-Catalyzed Asymmetric Cascade Allylation/Lactonization of Indole Esters: Access to Chiral Tricyclic Oxazinoindolones

Fan Xiao, Peiqin Liao, Xiaoguang Lu, Jin Wang, Xiu-Qin Dong and Chun-Jiang Wang

Org. Lett., 2022, 24, 8592
DOI: 10.1021/acs.orglett.2c03100

Catalytic Asymmetric Dearomatization of Indolyl Dihydropyridines through an Enamine Isomerization/Spirocyclization/Transfer Hydrogenation Sequence

Zi‐Lei Xia, Chao Zheng, Shou‐Guo Wang and Shu‐Li You

Angewandte Chemie, 2018, 130, 2683
DOI: 10.1002/ange.201712435

Organocatalytic Enantioselective Functionalization of Unactivated Indole C(sp3)−H Bonds

Dengke Ma, Zhihan Zhang, Min Chen, Zhenyang Lin and Jianwei Sun

Angew Chem Int Ed, 2019, 58, 15916
DOI: 10.1002/anie.201909397

2H‐[1,3]Oxazino[3,2‐α]indolin‐4(3H)‐ones: A Class Of Polyheterocyclic Indole‐Based Compounds

Jan M. Hartmann, Marita de Groot, Katja Schäringer, Kira Henke, Kari Rissanen and Markus Albrecht

Eur J Org Chem, 2018, 2018, 901
DOI: 10.1002/ejoc.201701630

1,8-Addition/[3,3]-Rearrangement in the Functionalization of Unactivated Indole C(sp3)–H Bonds

Shao-Shuai Chen, Xue Huang, Zheng-Xian Peng, Xin-Yi Yao, Jin-Rong Niu, Ai-Jun Ma and Xiang-Zhi Zhang

J. Org. Chem., 2026, 91, 5230
DOI: 10.1021/acs.joc.6c00355

An Axially Chiral Styrene–Phosphine Ligand for Pd-Catalyzed Asymmetric N-Alkylation of Indoles

Zhen-Bang Chen, Ru-Xin Liu, Zi-Hao Li, Tong-Mei Ding, He-Yuan Bai, Zengming Shen and Shu-Yu Zhang

J. Org. Chem., 2023, 88, 14719
DOI: 10.1021/acs.joc.3c01734

Catalytic Asymmetric [3+2] Cycloadditions of C‐3 Unsubstituted 2‐Indolylmethanols: Regio‐, Diastereo‐ and Enantioselective Construction of the Cyclopenta[b]indole Framework

Zi‐Qi Zhu, Yang Shen, Xiao‐Xue Sun, Ji‐Yu Tao, Jin‐Xi Liu and Feng Shi

Adv Synth Catal, 2016, 358, 3797
DOI: 10.1002/adsc.201600931

No Making Without Breaking: Nitrogen-Centered Carbonylation Reactions

Zhiping Yin, Jian-Xing Xu and Xiao-Feng Wu

ACS Catal., 2020, 10, 6510
DOI: 10.1021/acscatal.0c01479

Atroposelective Construction of Axially Chiral Alkene‐Indole Scaffolds via Catalytic Enantioselective Addition Reaction of 3‐Alkynyl‐2‐indolylmethanols†

Jing‐Yi Wang, Meng Sun, Xian‐Yang Yu, Yu‐Chen Zhang, Wei Tan and Feng Shi

Chin. J. Chem., 2021, 39, 2163
DOI: 10.1002/cjoc.202100214

Weak Nucleophiles in the Aza‐Michael Reaction

Alexander Yu. Rulev

Adv Synth Catal, 2023, 365, 1908
DOI: 10.1002/adsc.202300316

Regioselective Direct C‐Alkenylation of Indoles

Marino Petrini

Chemistry A European J, 2017, 23, 16115
DOI: 10.1002/chem.201702124

Reactions Involving Tryptamines and δ‐Allenyl Aldehydes: Competition between Pictet‐Spengler Reaction and Cyclization to 1‐Aminotetralins

Valérian Gobé, Vincent Gandon and Xavier Guinchard

Adv Synth Catal, 2018, 360, 1280
DOI: 10.1002/adsc.201701487

C7‐Functionalization of Indoles via Organocatalytic Enantioselective Friedel‐Crafts Alkylation of 4‐Amino‐ indoles with 2‐Butene‐1,4‐diones and 3‐Aroylacrylates

Tongkun Huang, Yunlong Zhao, Shanshui Meng, Albert S. C. Chan and Junling Zhao

Adv Synth Catal, 2019, 361, 3632
DOI: 10.1002/adsc.201900377

Heteroarene‐tethered Functionalized Alkyne Metamorphosis

Debojyoti Bag and Sanghapal D. Sawant

Chemistry A European J, 2021, 27, 1165
DOI: 10.1002/chem.202002154

Imidodiphosphoric acid catalysis

Steven M. Langdon

Tetrahedron, 2016, 72, 5247
DOI: 10.1016/j.tet.2016.06.031

Synthesis of 10H‐Indolo[1,2‐a]indole Derivatives via Intramolecular Cycloaddition and H‐Migration

Yulei Zhao, Shuai Li, Yuhang Fan, Xuqiang Guo, Xin Jiao, Laijin Tian and Xuejun Sun

Eur J Org Chem, 2021, 2021, 4358
DOI: 10.1002/ejoc.202100723

Organocatalytic enantioselective dearomatization of thiophenes by 1,10-conjugate addition of indole imine methides

Xingguang Li, Meng Duan, Peiyuan Yu, K. N. Houk and Jianwei Sun

Nat Commun, 2021, 12
DOI: 10.1038/s41467-021-25165-7

Organocatalytic Enantioselective Dearomatization of 2,3‐Disubstituted Indoles with α‐(3‐Indolyl)propargylic Alcohols

Hao Zhang, Zhenhua Song, Xiaohong Liu, Fang Fang, Pengfei Li and Wenjun Li

Adv Synth Catal, 2026, 368
DOI: 10.1002/adsc.70231

Phosphine-Mediated Sequential [2+4]/[2+3] Annulation to Construct Pyrroloquinolines

Junhui Lin, Yannan Zhu, Wei Cai and You Huang

Org. Lett., 2022, 24, 1593
DOI: 10.1021/acs.orglett.1c04388

Controllable Synthesis of N-Heterocycles via Hydride Transfer Strategy-Enabled Formal [5 + 1] and [5 + 2] Cyclizations

Ying Dong, Fangzhi Hu, Huixin Wu, Feng-Wei Guo, Liang Wang, Feng-Yu Du and Shuai-Shuai Li

Org. Lett., 2024, 26, 332
DOI: 10.1021/acs.orglett.3c03986

PFOA‐Catalyzed Regioselective Alkylation of Indolylmethanols with 2‐Alkylazaarenes**

Yi Zhong, Gang Hong, Zhicong Tang, Peng Yang, Qi Wang, Yu Gong and Limin Wang

ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202200218

Synthesis of Indole-Fused Dioxonanes via Brønsted Acid-Catalyzed (5 + 4) Cycloaddition

Xue Wang, Xiao-Fang Ma, Xiang-Nan Chen and Yu-Chen Zhang

J. Org. Chem., 2026, 91, 1776
DOI: 10.1021/acs.joc.5c02969

Asymmetric Synthesis of Hydrocarbazoles Catalyzed by an Octahedral Chiral‐at‐Rhodium Lewis Acid

Yong Huang, Liangliang Song, Lei Gong and Eric Meggers

Chemistry An Asian Journal, 2015, 10, 2738
DOI: 10.1002/asia.201500764

Hydroxy-Directed Enantioselective Hydroxyalkylation in the Carbocyclic Ring of Indoles

Marc Montesinos-Magraner, Carlos Vila, Gonzalo Blay, Isabel Fernández, M. Carmen Muñoz and José R. Pedro

Org. Lett., 2017, 19, 1546
DOI: 10.1021/acs.orglett.7b00354

Enantioselective Copper(II)/Box‐Catalyzed Synthesis of Chiral β3‐Tryptophan Derivatives

Elena A. Tarasenko, Ivan V. Shestakov, Victor B. Rybakov and Irina P. Beletskaya

ChemCatChem, 2019, 11, 3913
DOI: 10.1002/cctc.201900575

Visible‐Light‐Promoted Radical Cyclization and N−N Bond Cleavage Relay of N‐Aminopyridinium Ylides for Access to 2,3‐Difunctionalized Indoles

Meng‐Meng Xu, Wen‐Bin Cao, Xiao‐Ping Xu and Shun‐Jun Ji

Adv Synth Catal, 2022, 364, 2211
DOI: 10.1002/adsc.202200248

Enantioselective Synthesis of N-Alkylated Indoles Enabled by Nickel-Catalyzed C(sp3 )–C(sp3 ) Coupling

Xin Kui, Jingjie Zhou, Huijie Peng and Deyun Qian

Synthesis, 2025, 57, 2179
DOI: 10.1055/a-2515-0296

Enantioselective carbene-catalyzed tandem reaction for the efficient synthesis of pyrroloindolone and pyrrolidine derivatives with four consecutive stereocenters

Zhiying Li, Yao Chen, Xinyi Xu, Ziyi Xiao, Jiaqing Peng, Jianing An, Jianfeng Xu and Xingkuan Chen

Journal of Catalysis, 2025, 450, 116279
DOI: 10.1016/j.jcat.2025.116279

Theoretical insight into palladium-catalyzed gem‑difluorovinylation/cyclopropanation of N-methylindole and N-phenylindole with trifluoromethyl diazo compounds

Zi-Ming Huang, Yi Sun, Yong Wang and Xing-Wang Wang

Molecular Catalysis, 2024, 564, 114279
DOI: 10.1016/j.mcat.2024.114279

Organocatalytic Enantioselective Friedel‐Crafts Alkylation Reactions of Pyrroles

Daniel Gaviña, Marcos Escolano, Javier Torres, Gloria Alzuet‐Piña, María Sánchez‐Roselló and Carlos del Pozo

Adv Synth Catal, 2021, 363, 3439
DOI: 10.1002/adsc.202100313

Micellar catalysis enabled synthesis of indolylbenzothiazoles and their functionalization via Mn(II)-catalyzed C2–H amination using pyridones

Sanjeev Kumar, Dinesh Parshuram Satpute, Gargi Nikhil Vaidya, Mithilesh Nagpure, Shyam Kumar Lokhande, Deepak Meena and Dinesh Kumar

Tetrahedron Letters, 2020, 61, 152017
DOI: 10.1016/j.tetlet.2020.152017

Copper-Catalyzed Direct C2-Benzylation of Indoles with Alkylarenes

Hui-Jun Zhang, Feng Su and Ting-Bin Wen

J. Org. Chem., 2015, 80, 11322
DOI: 10.1021/acs.joc.5b01935

Recent Advances in the Catalytic Asymmetric Friedel–Crafts Reactions of Indoles

Tauqir Ahmad, Sardaraz Khan and Nisar Ullah

ACS Omega, 2022, 7, 35446
DOI: 10.1021/acsomega.2c05022

Construction of Bisindolines via Oxidative Coupling Cyclization

Ranran Cui, Jinxiang Ye, Jing Li, Wenhui Mo, Yu Gao and Haijun Chen

Org. Lett., 2020, 22, 116
DOI: 10.1021/acs.orglett.9b04037

Iron-catalyzed cascade bisindolations of donor–acceptor diazo compounds to construct bis(indolyl)methanes with quaternary carbon

Rongxiang Chen, Jutuan Xiao, Bingyang Wu, Wenya Liu, Kai-Kai Wang and Lantao Liu

Journal of Molecular Structure, 2026, 1349, 143747
DOI: 10.1016/j.molstruc.2025.143747

Cooperative Cation‐Binding Catalysis as an Efficient Approach for Enantioselective Friedel–Crafts Reaction of Indoles and Pyrrole

Mun Jong Kim, Lu Xue, Yidong Liu, Sushovan Paladhi, Si Joon Park, Hailong Yan and Choong Eui Song

Adv Synth Catal, 2017, 359, 811
DOI: 10.1002/adsc.201601198

Metal‐, Oxidant‐, and Additive‐Free Sulfenylation of Imidazo[1,2‐a]pyridines Using Sulfenamides and an I2 Catalyst

Huijie Qiao, Kun Zhao, Xilin Zhu, Xiaoxu Xu, Chunyang Wang, Lulu Zhong, Shixing Wang, Liting Yang, Dehong Yang, Guoqun Liu, Chunlei Lin and Mingli Jiao

Asian J Org Chem, 2023, 12
DOI: 10.1002/ajoc.202300292

Organocatalytic Enantioselective Friedel–Crafts Aminoalkylation of Indoles in the Carbocyclic Ring

Marc Montesinos-Magraner, Carlos Vila, Alejandra Rendón-Patiño, Gonzalo Blay, Isabel Fernández, M. Carmen Muñoz and José R. Pedro

ACS Catal., 2016, 6, 2689
DOI: 10.1021/acscatal.6b00260

Highly Stereoselective Assembly of α-Carbolinone Skeletons via N-Heterocyclic Carbene-Catalyzed [4 + 2] Annulations

Kai-Chuan Yang, Qing-Zhu Li, Yu Liu, Qing-Qing He, Yue Liu, Hai-Jun Leng, Ai-Qiong Jia, Shanmugavel Ramachandran and Jun-Long Li

Org. Lett., 2018, 20, 7518
DOI: 10.1021/acs.orglett.8b03277

Recent Advances on Photoinduced Cascade Strategies for the Synthesis of N‐Heterocycles

José Tiago M. Correia, Marilia S. Santos, Emanuele F. Pissinati, Gustavo P. da Silva and Márcio W. Paixão

The Chemical Record, 2021, 21, 2666
DOI: 10.1002/tcr.202100160

Synthesis of indole-5,6- and carbazole-2,3-dicarboxylic acid functional derivatives

Zh. V. Chirkova and S. I. Filimonov

Russ Chem Bull, 2017, 66, 379
DOI: 10.1007/s11172-017-1745-4

The Base-Promoted Intermolecular Hydroamination Reaction between Olefins and Indoles

Xiaoping Wang, Yilian Song, Wenhao Xu, Zhiyu Cao, Zhibin Huang and Yingsheng Zhao

J. Org. Chem., 2026, 91, 1788
DOI: 10.1021/acs.joc.5c02995

Intermediate‐Dependent Unusual [4+3], [3+2] and Cascade Reactions of 3‐Indolylmethanols: Controllable Chemodivergent and Stereoselective Synthesis of Diverse Indole Derivatives

Hong‐Hao Zhang, Zi‐Qi Zhu, Tao Fan, Jing Liang and Feng Shi

Adv Synth Catal, 2016, 358, 1259
DOI: 10.1002/adsc.201501063

Double C–H Functionalization of Indoles via Three-Component Reactions/CuCl2-Catalyzed Aerobic Dehydrogenative Coupling for the Synthesis of Polyfunctional Cyclopenta[b]indoles

Liqin Jiang, Weifeng Jin and Wenhao Hu

ACS Catal., 2016, 6, 6146
DOI: 10.1021/acscatal.6b01946

ChemInform Abstract: Strategies for the Asymmetric Functionalization of Indoles: An Update

Renato Dalpozzo

ChemInform, 2015, 46
DOI: 10.1002/chin.201516347

Electrochemical Phosphorochalcogenations for the Synthesis of Phosphorochalcogenothioates

Indrajit Karmakar, Xiang-Wei Huang, Yu-Hao Chen, Chieh-An Cheng, Pei-Chi Kuo and Chin-Fa Lee

J. Org. Chem., 2026, 91, 4962
DOI: 10.1021/acs.joc.5c03080

3-Nitroindoles Serving as N-Centered Nucleophiles for Aza-1,6-Michael Addition to para-Quinone Methides

Jian-Qiang Zhao, Wen-Jie Wang, Shun Zhou, Qi-Lin Xiao, Xi-Sha Xue, Yan-Ping Zhang, Yong You, Zhen-Hua Wang and Wei-Cheng Yuan

Molecules, 2023, 28, 5529
DOI: 10.3390/molecules28145529

Enantioselective Synthesis of Spiroindolines via Cascade Isomerization/Spirocyclization/Dearomatization Reaction

Zhiqiang Pan, Yuchang Liu, Fengchi Hu, Qinglong Liu, Wenbin Shang, Xu Ji and Chengfeng Xia

Org. Lett., 2020, 22, 1589
DOI: 10.1021/acs.orglett.0c00181

Rh-Catalyzed Reactions of 3-Diazoindolin-2-imines: Synthesis of Pyridoindoles and Tetrahydrofuropyrroloindoles

Chen Wang, Haojie Zhang, Bo Lang, Anni Ren, Ping Lu and Yanguang Wang

Org. Lett., 2015, 17, 4412
DOI: 10.1021/acs.orglett.5b01943

Advances in Catalytic Asymmetric Reactions Using 2-Indolylmethanols as Platform Molecules

Honghao Zhang and Feng Shi

Chinese Journal of Organic Chemistry, 2022, 42, 3351
DOI: 10.6023/cjoc202203018

Synthesis of Polycyclic Indolines by Utilizing a Reduction/Cyclization Cascade Reaction

Jingyu Zhang, Wei Xia, Meilin Qu, Saskia Huda, Jas S. Ward, Kari Rissanen and Markus Albrecht

Eur J Org Chem, 2021, 2021, 6097
DOI: 10.1002/ejoc.202101191

Isocyanide‐Based Multicomponent Reaction To Furnish N‐Functionalized Indoles by using N‐Acyliminium Ions as Key Intermediates

Guangsheng Cheng, Hongmei Deng, Xiang He, Yu Gao, Chunju Li, Xueshun Jia and Jian Li

Eur J Org Chem, 2017, 2017, 4507
DOI: 10.1002/ejoc.201700826

Chiral Brønsted Acid‐Catalyzed Enantioselective α‐Amidoalkylation Reactions: A Joint Experimental and Predictive Study

Eider Aranzamendi, Sonia Arrasate, Nuria Sotomayor, Humberto González‐Díaz and Esther Lete

ChemistryOpen, 2016, 5, 540
DOI: 10.1002/open.201600120

Weak Coordination-Guided Regioselective Direct Redox-Neutral C4 Allylation of Indoles with Morita–Baylis–Hillman Adducts

Sourav Pradhan, Pinaki Bhusan De and Tharmalingam Punniyamurthy

Org. Lett., 2019, 21, 9898
DOI: 10.1021/acs.orglett.9b03823

Oxidative Addition to the N–C Bond Vs Formation of the Zwitterionic Intermediate in Platinum(II)–Catalyzed Intramolecular Annulation of Alkynes to Form Indoles: Mechanistic Studies and Reaction Scope

Snigdha Rani Patra, Simon Watre Sangma, Arun Kumar Padhy and Sabyasachi Bhunia

J. Org. Chem., 2022, 87, 9714
DOI: 10.1021/acs.joc.2c00750

Heck Reaction Boosted Heterocycle Ring-Closing and Ring-Opening Rearrangement: A Strategy for the Synthesis of Indolyl-Type Ligands

Chong Li, Zhi-Chao Qi, Jing-Yu Li and Shang-Dong Yang

J. Org. Chem., 2021, 86, 16977
DOI: 10.1021/acs.joc.1c02117

Pd/BINAP/Peroxide‐Enabled Relay Multicomponent Reactions

Yan‐Nian Pan, Cheng‐Kai Yuan, Zhen‐Chun Li and Yi Lu

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70050

Enantioselective synthesis of N-alkylindoles enabled by nickel-catalyzed C-C coupling

Lun Li, Jiangtao Ren, Jingjie Zhou, Xiaomei Wu, Zhihui Shao, Xiaodong Yang and Deyun Qian

Nat Commun, 2022, 13
DOI: 10.1038/s41467-022-34615-9

Rh-Catalyzed C–H Alkynylation of Indole Derivatives with Silver(I)-Controlled Regiodivergence

Yaokun Zhao, Xingchi Li, Pengfei Zhou, Xing Han, Chenjie Zhang, Taoyuan Liang, Shuangliang Zhao and Zhuan Zhang

Org. Lett., 2024, 26, 7285
DOI: 10.1021/acs.orglett.4c02151

Design and Application of Indole‐Based Allylic Donors for Pd‐Catalyzed Decarboxylative Allylation Reactions†

Qing‐Qing Hang, Si‐Jia Liu, Lei Yu, Ting‐Ting Sun, Yu‐Chen Zhang, Guang‐Jian Mei and Feng Shi

Chin. J. Chem., 2020, 38, 1612
DOI: 10.1002/cjoc.202000104

Green and Facile Assembly of Diverse Fused N-Heterocycles Using Gold-Catalyzed Cascade Reactions in Water

Xiuwen Jia, Pinyi Li, Xiaoyan Liu, Jiafu Lin, Yiwen Chu, Jinhai Yu, Jiang Wang, Hong Liu and Fei Zhao

Molecules, 2019, 24, 988
DOI: 10.3390/molecules24050988

Oxidative N-Heterocyclic Carbene-Catalyzed Intramolecular Friedel–Crafts Alkylation of Indoles for the Synthesis of Spirocyclic Indolenines

Christian B. J. Breuers, Constantin G. Daniliuc and Armido Studer

Org. Lett., 2022, 24, 5314
DOI: 10.1021/acs.orglett.2c01927

Nickel-Catalyzed Straightforward and Regioselective C–H Alkenylation of Indoles with Alkenyl Bromides: Scope and Mechanistic Aspect

Rahul A. Jagtap, C. P. Vinod and Benudhar Punji

ACS Catal., 2019, 9, 431
DOI: 10.1021/acscatal.8b04267

Synthesis of α-Carbolinone Compounds Based on Tandem Cyclization Reaction of 2-Nitrochalcone and Ethyl Isocyanoacetate

Xinyao Sheng, Xinxin Li, Xiao Xing, Ling Pan, Qun Liu and Yifei Li

Chinese Journal of Organic Chemistry, 2025, 45, 2163
DOI: 10.6023/cjoc202409014

Highly Diastereo‐ and Enantioselective Synthesis of Tetrahydro‐5H‐Indolo[2,3‐b]quinolines through Copper‐Catalyzed Propargylic Dearomatization of Indoles

Wen Shao and Shu‐Li You

Chemistry A European J, 2017, 23, 12489
DOI: 10.1002/chem.201703443

Gold‐Catalyzed Functionalization Reactions of Indole

Valentina Pirovano

Eur J Org Chem, 2018, 2018, 1925
DOI: 10.1002/ejoc.201800125

Palladium‐Catalyzed Regioselective Synthesis of 1,2‐Fused Indole‐Diazepines via [5+2] Annulation of o‐Indoloanilines with Alkynes

Tushar Ulhas Thikekar and Chung‐Ming Sun

Adv Synth Catal, 2017, 359, 3388
DOI: 10.1002/adsc.201700741

Recent advances in the synthesis of N-heterocycles via Lewis acid-catalyzed/mediated cyclization of propargyl- and homopropargyl-amines and their derivatives

Bipin Kumar Behera, Priya Ghosh and Anil K. Saikia

Tetrahedron, 2024, 162, 134123
DOI: 10.1016/j.tet.2024.134123

Development and enantioselective synthesis of spirobiindoles via Rh-catalyzed asymmetric arylation-spirocyclization sequence

Long Yin, Yuxin Shi, Rong Meng, Jiapei Shan, Weiwei Sun, Weijun Yao, Xiaowei Dou and Dong Guo

Chinese Chemical Letters, 2026, 37, 111258
DOI: 10.1016/j.cclet.2025.111258

Engineering the L-tryptophan metabolism for efficient de novo biosynthesis of tryptophol in Saccharomyces cerevisiae

Ye Li, Jingzhen Sun, Zhenhao Fu, Yubing He, Xiaorui Chen, Shijie Wang, Lele Zhang, Jiansheng Jian, Weihua Yang, Chunli Liu, Xiuxia Liu, Yankun Yang and Zhonghu Bai

Biotechnol Biofuels, 2024, 17
DOI: 10.1186/s13068-024-02576-4

Asymmetric Synthesis of β-Indolyl Cyclopentanones and Cyclopentylamides with an All-Carbon Quaternary Stereocenter via Chiral Phosphoric Acid Catalyzed Friedel–Crafts Alkylation Reactions

Wei Liu, Subramani Rajkumar, Weihu Wu, Ziyu Huang and Xiaoyu Yang

Org. Lett., 2019, 21, 3563
DOI: 10.1021/acs.orglett.9b00963

Research Progress on Organocatalytic Functionalization of Indole in the Carbocyclic Ring

Haoning Zheng and Jinyu Liu

Acta Chimica Sinica, 2024, 82, 641
DOI: 10.6023/A24030094

Synergistic Cooperative Effect of Sodium borohydride‐Iodine Towards Cascade C−N and C−S/Se Bond Formation: One‐pot Regioselective Synthesis of 3‐Sulfenyl/selenyl Indoles and Mechanistic Insight

Aditya G. Lavekar, Danish Equbal, Saima and Arun K. Sinha

Adv Synth Catal, 2018, 360, 180
DOI: 10.1002/adsc.201701028

AgSbF6‐Catalyzed Tandem Reaction of 2‐Alkynylanilines with Cyclic Enynones: Efficient access to 3‐Furo[3,2‐c]chromenylindoles and Related Scaffolds

Anuradha Dagar, Soumitra Guin and Sampak Samanta

Asian J Org Chem, 2018, 7, 123
DOI: 10.1002/ajoc.201700511

Asymmetric synthesis of pyrrolo[1,2-a]indoles via organocatalytic [3 + 2] annulation of substituted 2-vinylindoles with azlactones

Wulin Yang, Hao Wang, Zirong Pan, Zhong Li and Weiping Deng

Chinese Chemical Letters, 2020, 31, 721
DOI: 10.1016/j.cclet.2019.09.008

Copper‐Catalyzed Ring Opening of Benzofurans and an Enantioselective Hydroamination Cascade

Qing‐Feng Xu‐Xu, Qiang‐Qiang Liu, Xiao Zhang and Shu‐Li You

Angewandte Chemie, 2018, 130, 15424
DOI: 10.1002/ange.201809003

MCDCalc: Markov Chain Molecular Descriptors Calculator for Medicinal Chemistry

Paula Carracedo-Reboredo, Ramiro Corona, Mikel Martinez-Nunes, Carlos Fernandez-Lozano, Georgia Tsiliki, Haralambos Sarimveis, Eider Aranzamendi, Sonia Arrasate, Nuria Sotomayor, Esther Lete, Cristian Robert Munteanu and Humbert González-Díaz

CTMC, 2020, 20, 305
DOI: 10.2174/1568026620666191226092431

Restricted Conformation of a Hydrogen Bond Mediated Catalyst Enables the Highly Efficient Enantioselective Construction of an All-Carbon Quaternary Stereocenter

Weici Xu, Xiang Shen, Qiao Ma, Lei Gong and Eric Meggers

ACS Catal., 2016, 6, 7641
DOI: 10.1021/acscatal.6b02080

Recent Advances in Metal‐ and Organocatalyzed Asymmetric Functionalization of Pyrroles

Biplob Borah, Kartikey Dhar Dwivedi and L. Raju Chowhan

Asian J Org Chem, 2021, 10, 2709
DOI: 10.1002/ajoc.202100427

Visible‐Light‐Driven Aza‐ortho‐quinone Methide Generation for the Synthesis of Indoles in a Multicomponent Reaction

Yi‐Yin Liu, Xiao‐Ye Yu, Jia‐Rong Chen, Ming‐Ming Qiao, Xiaotian Qi, De‐Qing Shi and Wen‐Jing Xiao

Angew Chem Int Ed, 2017, 56, 9527
DOI: 10.1002/anie.201704690

Tunable and Cooperative Catalysis for Enantioselective Pictet‐Spengler Reaction with Varied Nitrogen‐Containing Heterocyclic Carboxaldehydes

Yuk‐Cheung Chan, Marcus H. Sak, Scott A. Frank and Scott J. Miller

Angew Chem Int Ed, 2021, 60, 24573
DOI: 10.1002/anie.202109694

Catalytic Asymmetric Dearomatization of Indolyl Dihydropyridines through an Enamine Isomerization/Spirocyclization/Transfer Hydrogenation Sequence

Zi‐Lei Xia, Chao Zheng, Shou‐Guo Wang and Shu‐Li You

Angew Chem Int Ed, 2018, 57, 2653
DOI: 10.1002/anie.201712435

Porous metal oxides derived from Cu–Al layered double hydroxide as an efficient heterogeneous catalyst for the Friedel–Crafts alkylation of indoles with benzaldehydes under microwave irradiation

Thanh-Truc Hoang Nguyen, Xuan-Trang Thi Nguyen, Chinh Quoc Nguyen and Phuong Hoang Tran

Heliyon, 2018, 4, e00966
DOI: 10.1016/j.heliyon.2018.e00966

Catalytic Atroposelective Electrophilic Amination of Indoles

Jingyang Qin, Tong Zhou, Tai‐Ping Zhou, Langyu Tang, Honghua Zuo, Huaibin Yu, Guojiao Wu, Yuzhou Wu, Rong‐Zhen Liao and Fangrui Zhong

Angewandte Chemie, 2022, 134
DOI: 10.1002/ange.202205159

Pd-Catalyzed Asymmetric Larock Indole Synthesis to Access Axially Chiral N-Arylindoles

Genwei Zhang, Bin Yang, Junfeng Yang and Junliang Zhang

J. Am. Chem. Soc., 2024, 146, 5493
DOI: 10.1021/jacs.3c13356

Mechanism of the Alkylation of Indoles with Nitrostyrenes Catalyzed by Chiral-at-Metal Complexes

María Carmona, Ricardo Rodríguez, Vincenzo Passarelli and Daniel Carmona

Organometallics, 2019, 38, 988
DOI: 10.1021/acs.organomet.8b00925

Copper‐Catalyzed Domino C−C Bond Cleavage of 2,3‐Unsubstituted Indoles/Indolines and Oxindoles via Oxidation and Directed Insertion of 2‐Aminopyridines: Direct Access to Quinazolinediones

Owk Ravi, Andhavaram Ramaraju, Balasubramanian Sridhar and Surendar Reddy Bathula

Adv Synth Catal, 2018, 360, 3009
DOI: 10.1002/adsc.201800536

Lewis Acid‐Catalyzed (3+2) Cycloaddition of 2‐Indolylmethanols with β,γ‐Unsaturated α‐Ketoesters

Shuang Yang, Hai‐Qing Wang, Jun‐Nan Gao, Wen‐Xin Tan, Yu‐Chen Zhang and Feng Shi

Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200878

KOt‐Bu‐Catalyzed Chemo‐ and Regioselective Hydroamination of Allylic Sulfones with Indoles

Kundo Kim, Subin Park and Yunmi Lee

Eur J Org Chem, 2021, 2021, 125
DOI: 10.1002/ejoc.202001394

Regioselective C3Alkylation of Indoles for the Synthesis of Bis(indolyl)methanes and 3-Styryl Indoles

Ruiqin Zhang, Renchao Ma, Rener Chen, Lei Wang and Yongmin Ma

J. Org. Chem., 2024, 89, 1846
DOI: 10.1021/acs.joc.3c02551

Lewis Acid Catalyzed Regioselective Substitution of 2-Indolylmethanols with Pyrroles

Jun-Nan Gao, Wen-Xin Tan, Shuang Yang, Ning-Yi Wang, Jiebin Han, Da-Hua Wang, Yu-Chen Zhang and Feng Shi

Synthesis, 2025, 57, 1189
DOI: 10.1055/a-2503-3181

Spiro Indane-Based Phosphine-Oxazolines as Highly Efficient P,N Ligands for Enantioselective Pd-Catalyzed Allylic Alkylation of Indoles and Allylic Etherification

Zhongxuan Qiu, Rui Sun, Kun Yang and Dawei Teng

Molecules, 2019, 24, 1575
DOI: 10.3390/molecules24081575

Phosphine-Catalyzed Asymmetric Dearomative Annulation of 4-Nitroisoxazoles with Allenoates: Construction of Isoxazoline-Fused Bicyclo[3.3.0]octenes

Huamin Wang, Hong-Ding Xie, Jun-Long Ding, Yanjun Xie, Ying-Wu Lin and Junliang Zhang

Org. Lett., 2025, 27, 6812
DOI: 10.1021/acs.orglett.5c01958

Enantioselective Synthesis of Aminals Via Nickel-Catalyzed Hydroamination of 2-Azadienes with Indoles and N-Heterocycles

Ya Du, Shengzu Duan, Shuntao Huang, Tongqi Liu, Hongbin Zhang, Patrick J. Walsh and Xiaodong Yang

J. Am. Chem. Soc., 2024, 146, 30947
DOI: 10.1021/jacs.4c09750

Chiral Phosphoric Acid Catalyzed Intramolecular Dearomative Michael Addition of Indoles to Enones

Yong Zhou, Zi-Lei Xia, Qing Gu and Shu-Li You

Org. Lett., 2017, 19, 762
DOI: 10.1021/acs.orglett.6b03610

Gold‐Catalyzed Dual Annulation of Homopropargyl Alcohols with Nitrones: Synthesis of Tetrahydropyrano[4,3‐b]indole Scaffolds

Hanlin Wei, Su Zhou, Lihua Qiu, Yu Qian, Wenhao Hu and Xinfang Xu

Adv Synth Catal, 2019, 361, 3569
DOI: 10.1002/adsc.201900426

Asymmetric C-H and N-H Functionalization of Indoles Involving Central Chirality via Chiral Phosphoric Acid Catalysis

Alemayehu Gashaw, Dereje Kebebew Debeli and Meseret Chemeda

MROC, 2022, 19, 654
DOI: 10.2174/1570193X18666211006162836

Rhodium(I)-Catalyzed Direct Enantioselective C–H Functionalization of Indoles

Dong-Xing Zhu and Ming-Hua Xu

J. Org. Chem., 2023, 88, 7844
DOI: 10.1021/acs.joc.2c02624

Palladium-Catalyzed Asymmetric Intramolecular Dearomative Heck Reaction of Pyrrole Derivatives

Ping Yang and Shu-Li You

Org. Lett., 2018, 20, 7684
DOI: 10.1021/acs.orglett.8b03425

Enantioselective Aza-Friedel–Crafts Reaction of Indoles with Ketimines Catalyzed by Chiral Potassium Binaphthyldisulfonates

Manabu Hatano, Takuya Mochizuki, Keisuke Nishikawa and Kazuaki Ishihara

ACS Catal., 2018, 8, 349
DOI: 10.1021/acscatal.7b03708

Iron‐containing ionic liquid as an efficient and recyclable catalyst for the synthesis of C3‐substituted indole derivatives

Ying‐Chun Gu, Ren‐Ming Hu, Ming‐Ming Li and Da‐Zhen Xu

Applied Organom Chemis, 2019, 33
DOI: 10.1002/aoc.4782

Nickel(II)‐Catalyzed Diastereo‐ and Enantioselective [3+2] Cycloaddition of α‐Ketoesters with 2‐Nitrovinylindoles and 2‐Nitrovinylpyrroles

Wu‐Lin Yang, Zhong‐Tao Sun, Hao Sun and Wei‐Ping Deng

Chin. J. Chem., 2019, 37, 216
DOI: 10.1002/cjoc.201800572

Synthesis of 2‐(3‐Arylallylidene)‐3‐oxindoles via Dirhodium(II)‐Catalyzed Reaction of 3‐Diazoindolin‐2‐imines with 1‐Aryl‐Substituted Allylic Alcohols and Computational Insights

Ke Gao, Luyao Kou, Rui Fu and Xiaoguang Bao

Adv Synth Catal, 2020, 362, 1292
DOI: 10.1002/adsc.201901160

Dearomative Iodocyclization of N-(o-Alkynyl)aryl Isoindole

Zhiqiong Tang, Fang Zhang, Tengfei Yao, Xun-Shen Liu, Yuanyuan Liu and Lu Liu

J. Org. Chem., 2022, 87, 7531
DOI: 10.1021/acs.joc.2c00424

Chiral Brønsted acid-catalyzed Friedel–Crafts reaction of 3-indolylsulfamidates with indoles: Synthesis of enantioenriched bisindolylmethane sulfamates

Yerin Kim, Jiseon Lee, Junyang Jung and Sung-Gon Kim

Tetrahedron Letters, 2019, 60, 1625
DOI: 10.1016/j.tetlet.2019.05.003

Visible‐Light‐Driven Aza‐ortho‐quinone Methide Generation for the Synthesis of Indoles in a Multicomponent Reaction

Yi‐Yin Liu, Xiao‐Ye Yu, Jia‐Rong Chen, Ming‐Ming Qiao, Xiaotian Qi, De‐Qing Shi and Wen‐Jing Xiao

Angewandte Chemie, 2017, 129, 9655
DOI: 10.1002/ange.201704690

Cp*CoIII-Catalyzed Synthesis of Pyrido[2′,1′:2,3]pyrimido[1,6-a]indol-5-iums via Tandem C–H Activation and Subsequent Annulation from 1-(Pyridin-2-yl)-1H-indoles and Internal Alkynes

Yuhan Yang, Bo Li, Wenmin Liu, Rumeng Zhang, Lintao Yu, Qin-Ge Ma, Rongrong Lv, Donghua Du and Ting Li

J. Org. Chem., 2016, 81, 11335
DOI: 10.1021/acs.joc.6b02314

Rhodium(III)‐Catalyzed C−H Benzylation of Indole's C3 Position with Aza‐o‐Quinone Methides

Ruixing Liu, Yin Wei and Min Shi

Adv Synth Catal, 2020, 362, 3649
DOI: 10.1002/adsc.202000613

Switchable Reductive N-Trifluoroethylation and N-Trifluoroacetylation of Indoles with Trifluoroacetic Acid and Trimethylamine Borane

Yao-Fu Zeng, Ming-Xi Zhou, Yi-Na Li, Xin Wu, Yu Guo and Zhen Wang

Org. Lett., 2022, 24, 7440
DOI: 10.1021/acs.orglett.2c03011

Copper‐Catalyzed Sequential C(sp2)−H/C(sp3)−H Annulation of Indoles with Propargylic Alcohols to Access Hydrobenzo[b]carbazoles

Yi‐Rui Zhang, Zong‐Wang Qiu, Zhao‐Jie Fu, Shao‐Shuai Chen, Han‐Peng Pan, Bao Qiong Li, Ai‐Jun Ma and Xiang‐Zhi Zhang

Adv Synth Catal, 2024, 366, 1320
DOI: 10.1002/adsc.202301475

Synthesis of Spiroindolenines via Regioselective Gold(I)‐Catalyzed Cyclizations of N‐Propargyl Tryptamines

Valentin Magné, Angela Marinetti, Vincent Gandon, Arnaud Voituriez and Xavier Guinchard

Adv Synth Catal, 2017, 359, 4036
DOI: 10.1002/adsc.201700932

Pd‐Catalyzed Regioselective Direct Double C–H Arylation of 6,7‐Benzindoles

Ping‐Gui Li, Youqing Yang, Shuai Zhu, Hong‐Xi Li and Liang‐Hua Zou

Eur J Org Chem, 2019, 2019, 73
DOI: 10.1002/ejoc.201801473

Noncovalent Interaction-Based Probe Design for PET-Facilitated Fluorescence Sensing of Synthetic Cannabinoids

Jiahao Dong, Chuanfang Zhao, Jinliang Ning, Yuan Liu and Xincun Dou

ACS Omega, 2025, 10, 14306
DOI: 10.1021/acsomega.5c00540

Sulfonyl Azoles in the Synthesis of 3-Functionalized Azole Derivatives

Alessandro Palmieri and Marino Petrini

The Chemical Record, 2016, 16, 1353
DOI: 10.1002/tcr.201500291

Rhodium-Catalyzed NH-Indole-Directed C–H Carbonylation with Carbon Monoxide: Synthesis of 6H-Isoindolo[2,1-a]indol-6-ones

Qiufeng Huang, Qingshuai Han, Shurong Fu, Zizhu Yao, Lv Su, Xiaofeng Zhang, Shen Lin and Shengchang Xiang

J. Org. Chem., 2016, 81, 12135
DOI: 10.1021/acs.joc.6b01200

The Development of a Palladium-Catalyzed Tandem Addition/Cyclization for the Construction of Indole Skeletons

Shuling Yu, Linjun Qi, Kun Hu, Julin Gong, Tianxing Cheng, Qingzong Wang, Jiuxi Chen and Huayue Wu

J. Org. Chem., 2017, 82, 3631
DOI: 10.1021/acs.joc.7b00148

Iodine‐Catalyzed Vinylogous Friedel–Crafts Alkylation of Indoles: Facile Access to Versatile β‐(3‐Indolyl)carbonyl Frameworks

Tapas Kumar Achar, Johncy Jacob, Manash Pratim Sarmah, Manivannan Muthukumar, Arvind Mathur and Richland Tester

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.70009

Regioselective and Enantioselective Synthesis of β‐Indolyl Cyclopentenamides by Chiral Anion Catalysis

Subramani Rajkumar, Jiawen Wang, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng and Xiaoyu Yang

Angewandte Chemie, 2018, 130, 13677
DOI: 10.1002/ange.201807010

Visible‐Light‐Promoted Alkylation of Indoles with Tertiary Amines by the Oxidation of a sp3 C‐H Bond

Xuan Ding, Chun‐Lin Dong, Zhi Guan and Yan‐Hong He

Adv Synth Catal, 2018, 360, 762
DOI: 10.1002/adsc.201701131

Rhodium-catalyzed NH-indole-directed ortho C H coupling of 2-arylindoles with diazo compounds via metal carbene migratory insertion

Xiemin Guo, Qingshuai Han, Ziyuan Tang, Lv Su, Xinyu Zhang, Xiaofeng Zhang, Shen Lin and Qiufeng Huang

Tetrahedron Letters, 2018, 59, 1568
DOI: 10.1016/j.tetlet.2018.03.027

New syntheses of cycloalka[b]indoles

R. R. Gataullin

Russ J Org Chem, 2016, 52, 1227
DOI: 10.1134/S1070428016090013

Copper‐Catalyzed Ring Opening of Benzofurans and an Enantioselective Hydroamination Cascade

Qing‐Feng Xu‐Xu, Qiang‐Qiang Liu, Xiao Zhang and Shu‐Li You

Angew Chem Int Ed, 2018, 57, 15204
DOI: 10.1002/anie.201809003

Enantioselective Friedel-Crafts alkylation of indoles with cyclic N-sulfonyl ketimino esters catalyzed by Cu(II) complex bearing binaphthyl-proline-imidazoline-based ligands

Chao Yao, Yan Zhao, Yangyang Ou, Tengyang Zhang and Yue-Ming Li

Tetrahedron, 2026, 193, 135136
DOI: 10.1016/j.tet.2026.135136

A highly active copper-based metal-organic framework catalyst for a friedel–crafts alkylation in the synthesis of bis(indolyl)methanes under ultrasound irradiation

Huong T.D. Nguyen, The T. Nguyen, Phuong T.K. Nguyen and Phuong Hoang Tran

Arabian Journal of Chemistry, 2020, 13, 1377
DOI: 10.1016/j.arabjc.2017.11.009

Catalytic Atroposelective Electrophilic Amination of Indoles

Jingyang Qin, Tong Zhou, Tai‐Ping Zhou, Langyu Tang, Honghua Zuo, Huaibin Yu, Guojiao Wu, Yuzhou Wu, Rong‐Zhen Liao and Fangrui Zhong

Angew Chem Int Ed, 2022, 61
DOI: 10.1002/anie.202205159

Stereoselective Haliranium, Thiiranium and Seleniranium Ion‐Triggered Friedel–Crafts‐Type Alkylations for Polyene Cyclizations

Biswajit Maji

Adv Synth Catal, 2019, 361, 3453
DOI: 10.1002/adsc.201900028

Ynones in dearomative spirocyclisation processes; a review

Richard J.K. Taylor and William P. Unsworth

Tetrahedron Chem, 2024, 9, 100055
DOI: 10.1016/j.tchem.2023.100055

Catalytic Enantioselective Aza-Friedel–Crafts Reaction of Ketimines and Indoles for Constructing Tetrasubstituted Carbon Centers Adjacent to Two Heteroatoms

Min Zhang, Hai-Hui Liu, Zhen Yao, Rui-Rui Li, Lei Yang, Xiong-Li Liu and Jian-Qiang Zhao

J. Org. Chem., 2025, 90, 11802
DOI: 10.1021/acs.joc.5c00712

Tunable and Cooperative Catalysis for Enantioselective Pictet‐Spengler Reaction with Varied Nitrogen‐Containing Heterocyclic Carboxaldehydes

Yuk‐Cheung Chan, Marcus H. Sak, Scott A. Frank and Scott J. Miller

Angewandte Chemie, 2021, 133, 24778
DOI: 10.1002/ange.202109694

Electrocatalytic asymmetric reduction of ethyl benzoylformate on bimetallic Ag–Cu cathodes

Shuo Wang, Yi Shi, Yue Hou, Si-Li Shan, Huan Wang and Jia-Xing Lu

J Appl Electrochem, 2020, 50, 973
DOI: 10.1007/s10800-020-01449-6

Asymmetric Synthesis of Fused Polycyclic Indazoles through Aminocatalyzed Aza-Michael Addition/Intramolecular Cyclization

Maxime Giardinetti, Jérôme Marrot, Xavier Moreau, Vincent Coeffard and Christine Greck

J. Org. Chem., 2016, 81, 6855
DOI: 10.1021/acs.joc.6b01201

Palladium(0)‐Catalyzed Intermolecular Asymmetric Cascade Dearomatization Reaction of Indoles with Propargyl Carbonate

Lu Ding, Run‐Duo Gao and Shu‐Li You

Chemistry A European J, 2019, 25, 4330
DOI: 10.1002/chem.201900425

Enantioselective 2-Alkylation of 3-Substituted Indoles with Dual Chiral Lewis Acid/Hydrogen-Bond-Mediated Catalyst

Zijun Zhou, Yanjun Li, Lei Gong and Eric Meggers

Org. Lett., 2017, 19, 222
DOI: 10.1021/acs.orglett.6b03500

Lipase-catalyzed kinetic resolution approach toward enantiomerically enriched 1-(β-hydroxypropyl)indoles

Paweł Borowiecki, Iwona Justyniak and Zbigniew Ochal

Tetrahedron: Asymmetry, 2017, 28, 1717
DOI: 10.1016/j.tetasy.2017.10.010

Nickel-Catalyzed Asymmetric Friedel–Crafts Propargylation of 3-Substituted Indoles with Propargylic Carbonates Bearing an Internal Alkyne Group

Yusuke Miyazaki, Biao Zhou, Hiroaki Tsuji and Motoi Kawatsura

Org. Lett., 2020, 22, 2049
DOI: 10.1021/acs.orglett.0c00465

Acid‐Relayed Organocatalytic exo‐Diels–Alder Cycloaddition of Cyclic Enones with 2‐Vinyl‐1H‐indoles

Ji‐Wei Ren, Zhao‐Fang Zhou, Jun‐An Xiao, Xiao‐Qing Chen and Hua Yang

Eur J Org Chem, 2016, 2016, 1264
DOI: 10.1002/ejoc.201501619

Modular Access to Diverse Bridged Indole Alkaloid Mimics via a Gold-Triggered Cascade Dearomative Spirocarbocyclization/[4 + 2] Cycloaddition Sequence

Yi He, Zhen Liu, Danjun Wu, Zhenghua Li, Koen Robeyns, Luc Van Meervelt and Erik V. Van der Eycken

Org. Lett., 2019, 21, 4469
DOI: 10.1021/acs.orglett.9b01296

Copper‐Catalyzed Addition of Grignard Reagents to in situ Generated Indole‐Derived Vinylogous Imines

Luo Ge, Mercedes Zurro and Syuzanna R. Harutyunyan

Chemistry A European J, 2020, 26, 16277
DOI: 10.1002/chem.202004232

Organocatalytic, Enantioselective Friedel–Crafts Reaction of Indoles in the Carbocyclic Ring and Electron-Rich Phenols

Jin-Yu Liu, Xie-Chao Yang, Hong Lu, Yu-Cheng Gu and Peng-Fei Xu

Org. Lett., 2018, 20, 2190
DOI: 10.1021/acs.orglett.8b00503

Gold‐catalyzed Rapid Construction of Nitrogen‐containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity

Jin Qiao, Xiuwen Jia, Pinyi Li, Xiaoyan Liu, Jingwei Zhao, Yu Zhou, Jiang Wang, Hong Liu and Fei Zhao

Adv Synth Catal, 2019, 361, 1419
DOI: 10.1002/adsc.201801494

Visible‐Light‐Induced Direct Photocatalytic Carboxylation of Indoles with CBr4/MeOH

Qing‐Qing Yang, Marianna Marchini, Wen‐Jing Xiao, Paola Ceroni and Marco Bandini

Chemistry A European J, 2015, 21, 18052
DOI: 10.1002/chem.201503787

Silyl‐Substituted Planar Chiral Phosphoric Acids with Ferrocene‐bridged Paracyclophane Frameworks: Synthesis, Characterization, and Uses in Enantioselective aza‐Friedel‐Crafts Reactions

Jérémy Stemper, Kévin Isaac, Nayan Ghosh, Hortense Lauwick, Gaëtan Le Duc, Pascal Retailleau, Arnaud Voituriez, Jean‐François Betzer and Angela Marinetti

Adv Synth Catal, 2017, 359, 519
DOI: 10.1002/adsc.201600920

Phosphine‐Catalyzed [3+2] Cycloaddition and Vinylation of Indole‐Derived α,α‐Dicyanoolefins with γ‐Substituted Allenoates

Chang Yuan, Hao Tan, Xue‐Fei Jiang, Si Liu, Lu Jiang, Qi‐Ying Cao, Xing‐Jie Xu, Xiao‐Yan Deng, Guan‐Nan Pan, Jian‐Yang Chen and Hai‐Lei Cui

Asian J Org Chem, 2019, 8, 1893
DOI: 10.1002/ajoc.201900393

Synthesis of Biologically Relevant Heterocycles in Aqueous Media

Goutam Brahmachari

Asian J Org Chem, 2018, 7, 1982
DOI: 10.1002/ajoc.201800396

The Selective N‐Functionalization of Indoles via aza‐Michael Addition in the Ligand Sphere of a Chiral Nickel(II) Complex: Asymmetric Synthesis of (S)‐1H‐Indole‐Alanine Derivatives

Vladimir A. Larionov, Tat'yana F. Savel'yeva, Michael G. Medvedev, Nadezhda V. Stoletova, Alexander F. Smol'yakov, Zalina T. Gugkaeva, Thomas Cruchter and Victor I. Maleev

Eur J Org Chem, 2019, 2019, 3699
DOI: 10.1002/ejoc.201900650

Photoinduced [3+2] Annulation of Alkene with o-Iodoanilines: An Expedient Approach to Indolines

Xinxin Zhao, Lin Guo, Chao Yang and Wujiong Xia

Synthesis, 2021, 53, 1341
DOI: 10.1055/s-0040-1705963

Enantioselective Access to N-Alkylindoles via NHC–Nickel-Mediated 1,2-Difunctionalization of 1-Vinylindoles

Meihong Luo, Hao Li, Jun Liu and Hongyu Wang

Org. Lett., 2025, 27, 12308
DOI: 10.1021/acs.orglett.5c03887

Catalyst-Controlled Chemoselective Reaction of 3-Indolylmethanols with Cyclic Enaminones Leading to C2-Functionalized Indoles

Xin Li, Wei Tan, Yu-Xin Gong and Feng Shi

J. Org. Chem., 2015, 80, 1841
DOI: 10.1021/jo502782b

Heterogeneous Photocatalytic C–H Functionalization of Indoles with Diazo Compounds Enabled by Carbon Nitride

Peiying Li, Rong Chang, Fujun Guan, Wenjing Yang, Cong-Ying Zhou and Zhen Guo

J. Org. Chem., 2023, 88, 8703
DOI: 10.1021/acs.joc.3c00574

Synthesis of Unsymmetrical Bisindolylmethanes by Reaction of Indolylmagnesium Bromides with Sulfonyl Indoles

Lixia Yuan, Alessandro Palmieri and Marino Petrini

Adv Synth Catal, 2020, 362, 1509
DOI: 10.1002/adsc.201901357

Direct Access to Functionalized Indoles via Single Electron Oxidation Induced Coupling of Diarylamines with 1,3-Dicarbonyl Compounds

Taoyuan Liang, He Zhao, Lingzhen Gong, Huanfeng Jiang and Min Zhang

Org. Lett., 2019, 21, 6736
DOI: 10.1021/acs.orglett.9b02349

3,4-Annulated Indoles via Tandem Cyclopropane Ring-Opening/Conia-ene and Michael Addition/Conia-ene Reactions

Shane R. Cochrane and Michael A. Kerr

Org. Lett., 2022, 24, 5509
DOI: 10.1021/acs.orglett.2c01810

Radical-Initiated Dearomative Annulation of Tryptamine-Derived Isocyanides: Selective Synthesis of CF3-Substituted β-Aza-spiroindolines and β-Carbolines

Luo-Rong Yuan, You Zi, Shun-jun Ji and Xiao-Ping Xu

J. Org. Chem., 2024, 89, 15979
DOI: 10.1021/acs.joc.4c02302

An Arylation Strategy to Propargylamines: Catalytic Asymmetric Friedel–Crafts‐type Arylation Reactions of C‐Alkynyl Imines

Yingcheng Wang, Liang Jiang, Long Li, Jun Dai, Dan Xiong and Zhihui Shao

Angewandte Chemie, 2016, 128, 15366
DOI: 10.1002/ange.201608918

Thiourea catalyzed 1,6-conjugate addition of indoles to para-quinone methides

Guangmiao Wu, Tao Li, Fuhai Liu, Yulong Zhao, Shiqiang Ma, Shouchu Tang, Xingang Xie and Xuegong She

Tetrahedron Letters, 2021, 81, 153315
DOI: 10.1016/j.tetlet.2021.153315

Quinone methides and indole imine methides as intermediates in enantioselective catalysis

Xingguang Li, Zhiyang Li and Jianwei Sun

Nat. Synth, 2022, 1, 426
DOI: 10.1038/s44160-022-00072-x

Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co–Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions

Isaac Choi, Hyunho Chung, Jang Won Park and Young Keun Chung

Org. Lett., 2016, 18, 5508
DOI: 10.1021/acs.orglett.6b02659

Regio- and Enantioselective Friedel–Crafts Benzhydrylation of Indoles in Carbocyclic Ring with ortho-Quinomethanes: Access to Chiral Diarylindolylmethanes

Ming-Ming Chu, Xue-Yang Chen, Yi-Feng Wang, Suo-Suo Qi, Zhen-Hui Jiang, Dan-Qian Xu and Zhen-Yuan Xu

J. Org. Chem., 2020, 85, 9491
DOI: 10.1021/acs.joc.9b03479

Aymmetric Aza-Friedel–Crafts Reaction of Isatin-Derived Ketimines with Indoles Catalyzed by a Chiral Phase-Transfer Catalyst

Jing Li, Zhonglin Wei, Jungang Cao, Dapeng Liang, Yingjie Lin and Haifeng Duan

J. Org. Chem., 2022, 87, 2532
DOI: 10.1021/acs.joc.1c02477

Intermolecular Enantioselective Dearomative Oxidative Heck Reaction of Indoles

Weiyang Gao, Weichao Deng, Yang Gao, Renxiao Liang and Yixia Jia

Acta Chimica Sinica, 2024, 82, 1
DOI: 10.6023/A23100472

Enantioselective Catalytic Synthesis of N-alkylated Indoles

Dmitri Trubitsõn and Tõnis Kanger

Symmetry, 2020, 12, 1184
DOI: 10.3390/sym12071184

Synthesis of 7‐Phenylindole Derivatives through Rhodium‐Catalyzed Dehydrogenative Coupling of 2‐(Acetylamino)‐1,1’‐biphenyls with Alkynes

Ryudai Michikita, Yoshinosuke Usuki and Tetsuya Satoh

Asian J Org Chem, 2021, 10, 868
DOI: 10.1002/ajoc.202100071

Temperature Dual Enantioselective Control in a Rhodium‐Catalyzed Michael‐Type Friedel–Crafts Reaction: A Mechanistic Explanation

Isabel Méndez, Ricardo Rodríguez, Víctor Polo, Vincenzo Passarelli, Fernando J. Lahoz, Pilar García‐Orduña and Daniel Carmona

Chemistry A European J, 2016, 22, 11064
DOI: 10.1002/chem.201601301

Direct, Metal‐free C(sp2)−H Chalcogenation of Indoles and Imidazopyridines with Dichalcogenides Catalysed by KIO3

Jamal Rafique, Sumbal Saba, Marcelo S. Franco, Luana Bettanin, Alex R. Schneider, Lais T. Silva and Antonio L. Braga

Chemistry A European J, 2018, 24, 4173
DOI: 10.1002/chem.201705404

Regioselective and Enantioselective Synthesis of β‐Indolyl Cyclopentenamides by Chiral Anion Catalysis

Subramani Rajkumar, Jiawen Wang, Sujuan Zheng, Donglei Wang, Xueqian Ye, Xuejiao Li, Qian Peng and Xiaoyu Yang

Angew Chem Int Ed, 2018, 57, 13489
DOI: 10.1002/anie.201807010

Synthesis of Chiral Bis(3-indolyl)methanes Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter via Nickel-Catalyzed Asymmetric Friedel–Crafts Alkylation Reaction

Wen-Jing Zhu, Jun-Fang Gong and Mao-Ping Song

J. Org. Chem., 2020, 85, 9525
DOI: 10.1021/acs.joc.0c00336

Palladium-Catalyzed, Enantioselective (3 + 2)-Cycloannulation of β-Keto Esters with Alkylidene 2H-Indoles toward Complex Indole-Based Heterocycles

Fabian Göricke and Christoph Schneider

Org. Lett., 2020, 22, 6101
DOI: 10.1021/acs.orglett.0c02166

Catalytic Asymmetric Dearomative [3 + 2] Cycloaddition of Electron-Deficient Indoles with All-Carbon 1,3-Dipoles

Meng Sun, Zi-Qi Zhu, Ling Gu, Xiao Wan, Guang-Jian Mei and Feng Shi

J. Org. Chem., 2018, 83, 2341
DOI: 10.1021/acs.joc.7b03259

Catalytic Asymmetric Chemodivergent C2 Alkylation and [3 + 2]-Cycloaddition of 3-Methylindoles with Aziridines

Yali Xu, Fenzhen Chang, Weidi Cao, Xiaohua Liu and Xiaoming Feng

ACS Catal., 2018, 8, 10261
DOI: 10.1021/acscatal.8b02880

Regio- and Enantioselective Synthesis of Diarylindolylmethanes via Lewis Acid Catalyzed Friedel–Crafts Alkylation of Indoles with In Situ Generated o-Quinone Methides

Jin Won Lee, Hee Seo Jung and Do Hyun Ryu

Org. Lett., 2025, 27, 10400
DOI: 10.1021/acs.orglett.5c03263

Aminocatalyzed Cascade Synthesis of Enantioenriched 1,7‐Annulated Indoles from Indole‐7‐Carbaldehyde Derivatives and α,β‐Unsaturated Aldehydes

Maxime Giardinetti, Xavier Moreau, Vincent Coeffard and Christine Greck

Adv Synth Catal, 2015, 357, 3501
DOI: 10.1002/adsc.201500629

Photoinduced Asymmetric Dearomative Hydroalkylation of Electron-Deficient Indoles with Alkyltrifluoroborates

Zitong Zhu, Dong Ye, Yuqiao Zhou, Weidi Cao and Xiaoming Feng

Org. Lett., 2025, 27, 9782
DOI: 10.1021/acs.orglett.5c03192

Asymmetric Michael Addition of 2-Acetyl Azaarenes to β-CF3-β-(3-indolyl)nitroalkenes Catalyzed by a Cobalt(II)/(imidazoline-oxazoline) Complex

Cong Wang, Nan Li, Wen-Jing Zhu, Jun-Fang Gong and Mao-Ping Song

J. Org. Chem., 2019, 84, 191
DOI: 10.1021/acs.joc.8b02601

When Indoles Meet Allene and its Derivatives

José M. Alonso and María Paz Muñoz

Eur J Org Chem, 2020, 2020, 7197
DOI: 10.1002/ejoc.202001269

Application of 3-Alkyl-2-vinylindoles in Catalytic Asymmetric Dearomative (2+3) Cycloadditions

Ke-Wei Chen, Dan-Dan Wang, Si-Jia Liu, Xue Wang, Yu-Chen Zhang, Yi-Ming Tian, Qiong Wu and Feng Shi

J. Org. Chem., 2021, 86, 10427
DOI: 10.1021/acs.joc.1c01105

Lewis Acid-Catalyzed [2+4] Cyclization of 3-Alkyl-2-vinylindoles with α,β-Unsaturated N-Sulfonyl Ketimines

Lixing Sun, Tingting Sun, Haiqing Wang, Shufang Wu, Xiaoye Wang, Tianya Liu and Yuchen Zhang

Chinese Journal of Organic Chemistry, 2023, 43, 2178
DOI: 10.6023/cjoc202210037

Gold(I)‐Catalyzed Dearomative [2+2]‐Cycloaddition of Indoles with Activated Allenes: A Combined Experimental–Computational Study

Riccardo Ocello, Assunta De Nisi, Minqiang Jia, Qing‐Qing Yang, Magda Monari, Pietro Giacinto, Andrea Bottoni, Gian Pietro Miscione and Marco Bandini

Chemistry A European J, 2015, 21, 18445
DOI: 10.1002/chem.201503598

One-Pot Three-Component Coupling Reaction of α-Amino Aryl Ketones, Indoles, and Perbromomethane Under Mild Conditions

De Chen, Hao Lu, Yuxuan Liu, Wei Deng, Renhua Qiu and Jiannan Xiang

Front. Chem., 2022, 10
DOI: 10.3389/fchem.2022.825772

Synthesis of 2-arylindoles by Suzuki coupling reaction of 3-bromoindoles with hindered benzoboronic acids

Guizhou Yue, Yao Wu, Caimei Wu, Zhongqiong Yin, Huabao Chen, Xianxiang Wang and Zuming Zhang

Tetrahedron Letters, 2017, 58, 666
DOI: 10.1016/j.tetlet.2017.01.014

Asymmetric Synthesis of Cyclopenta[3,4]pyrroloindolones via N-Heterocyclic Carbene-Catalyzed Michael/Aldol/Lactamization Cascade Reaction

Yu-Jie Yang, Yuanyuan Ji, Liangliang Qi, Guanjun Wang and Xin-Ping Hui

Org. Lett., 2017, 19, 3271
DOI: 10.1021/acs.orglett.7b01411

Palladium-Catalyzed Intermolecular Heck-Type Dearomative [4 + 2] Annulation of 2H-Isoindole Derivatives with Internal Alkynes

Tengfei Yao, Fang Zhang, Junliang Zhang and Lu Liu

Org. Lett., 2020, 22, 5063
DOI: 10.1021/acs.orglett.0c01643

Electrochemical Oxidative Selenation of 4H‐Pyrido‐[1,2‐a]‐pyrimidin‐4‐ones with Diorganyldiselenides

Jinyang Chen, Yao Xiao, Xianhui You, Shiqi Li, Yuwei Fu and Yuejun Ouyang

ChemistrySelect, 2023, 8
DOI: 10.1002/slct.202203879

Brønsted Acid‐Catalyzed [3+2] Cyclodimerization of 3‐Alkyl‐ 2‐vinylindoles Leading to the Diastereoselective Construction of a Pyrroloindole Framework

Lei Yin, Yang Wang, Meng Sun and Feng Shi

Adv Synth Catal, 2016, 358, 1093
DOI: 10.1002/adsc.201501116

Mechanisms and Stereoselectivities of NHC‐Catalyzed [3 + 4] Cycloaddition Reaction between Isatin‐Derived Enal and N‐(ortho‐Chloromethyl)aryl Amide

Yan Li and Zhiqiang Zhang

Eur J Org Chem, 2019, 2019, 2989
DOI: 10.1002/ejoc.201900087

Functionalized S-perfluorinated sulfoximines: Preparation and evaluation in catalytic processes

Thanh-Nghi Le, Patrick Diter, Bruce Pégot, Chloée Bournaud, Martial Toffano, Regis Guillot, Giang Vo-Thanh, Yurii Yagupolskii and Emmanuel Magnier

Journal of Fluorine Chemistry, 2015, 179, 179
DOI: 10.1016/j.jfluchem.2015.06.020

Reaction of Indole‐2‐Carboxylates/Carboxylic Acids with Propargylic Alcohols: Dearomative Ring Expansion/Spirocyclization vs Fused Pentacyclics

Mallepalli Shankar, Uruvakili Anasuyamma and K. C. Kumara Swamy

Adv Synth Catal, 2022, 364, 643
DOI: 10.1002/adsc.202101038

Organocatalytic Asymmetric 3‐Allenylation of Indoles via Remote Stereocontrolled 1,10‐Additions of Alkynyl Indole Imine Methides

Ziyang Wang, Yuyu Cheng, Zhibin Yue, Xuling Chen, Pengfei Li and Wenjun Li

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200399

Application of 3-Methyl-2-vinylindoles in Catalytic Asymmetric Povarov Reaction: Diastereo- and Enantioselective Synthesis of Indole-Derived Tetrahydroquinolines

Wei Dai, Xiao-Li Jiang, Ji-Yu Tao and Feng Shi

J. Org. Chem., 2016, 81, 185
DOI: 10.1021/acs.joc.5b02476

Ring-Opening Reconstruction of Indoles Enabled by C–N Bond Cleavage: Synthesis of Benzo[c]pyrazolo[3,4-h][2,6]naphthyridine Derivatives

You Zhou, Li-Sheng Wang, Ze-Hua Li, Shuang-Gui Lei, Bo-Cheng Tang, Ping He, Kai-Lu Zheng, Yu Lan and An-Xin Wu

Org. Lett., 2025, 27, 11848
DOI: 10.1021/acs.orglett.5c03710

Catalytic Asymmetric Nucleophilic Addition of 3-Vinyl Indoles to Imines

Jia-Hui Xue, Ming Shi, Feng Yu, Xiao-Yun Li, Wen Ren, Li-Na Fu and Qi-Xiang Guo

Org. Lett., 2016, 18, 3874
DOI: 10.1021/acs.orglett.6b01880