The impact of sample preparation on the elemental composition of soft tissues assessed by laser ablation ICP-MS

Agata Jagielska, Anna Ruszczyńska, Ewa Bulska and Barbara Wagner

J. Anal. At. Spectrom., 2020, 35, 1340
DOI: 10.1039/D0JA00115E

Imaging metals in biology: balancing sensitivity, selectivity and spatial resolution

Dominic J. Hare, Elizabeth J. New, Martin D. de Jonge and Gawain McColl

Chem. Soc. Rev., 2015, 44, 5941
DOI: 10.1039/C5CS00055F

Recent applications of laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) for biological sample analysis: a follow-up review

D. Pozebon, G. L. Scheffler and V. L. Dressler

J. Anal. At. Spectrom., 2017, 32, 890
DOI: 10.1039/C7JA00026J

An iron–dopamine index predicts risk of parkinsonian neurodegeneration in the substantia nigra pars compacta

Dominic J. Hare, Peng Lei, Scott Ayton, Blaine R. Roberts, Rudolf Grimm, Jessica L. George, David P. Bishop, Alison D. Beavis, Sarah J. Donovan, Gawain McColl, Irene Volitakis, Colin L. Masters, Paul A. Adlard, Robert A. Cherny, Ashley I. Bush, David I. Finkelstein and Philip A. Doble

Chem. Sci., 2014, 5, 2160
DOI: 10.1039/C3SC53461H

Visualising mouse neuroanatomy and function by metal distribution using laser ablation-inductively coupled plasma-mass spectrometry imaging

Bence Paul, Dominic J. Hare, David P. Bishop, Chad Paton, Van Tran Nguyen, Nerida Cole, Megan M. Niedwiecki, Erica Andreozzi, Angela Vais, Jessica L. Billings, Lisa Bray, Ashley I. Bush, Gawain McColl, Blaine R. Roberts, Paul A. Adlard, David I. Finkelstein, John Hellstrom, Janet M. Hergt, Jon D. Woodhead and Philip A. Doble

Chem. Sci., 2015, 6, 5383
DOI: 10.1039/C5SC02231B

Understanding metal homeostasis in primary cultured neurons. Studies using single neuron subcellular and quantitative metallomics

Robert A Colvin, Barry Lai, William R Holmes and Daewoo Lee

Metallomics, 2015, 7, 1111
DOI: 10.1039/c5mt00084j

A time-course analysis of changes in cerebral metal levels following a controlled cortical impact

Stuart D. Portbury, Dominic J. Hare, Charlotte Sgambelloni, David I. Finkelstein and Paul A. Adlard

Metallomics, 2016, 8, 193
DOI: 10.1039/C5MT00234F

Sample preparation with sucrose cryoprotection dramatically alters Zn distribution in the rodent hippocampus, as revealed by elemental mapping

M. J. Pushie, A. Hollings, J. Reinhardt, S. M. Webb, V. Lam, R. Takechi, J. C. Mamo, P. G. Paterson, M. E. Kelly, G. N. George, I. J. Pickering and M. J. Hackett

J. Anal. At. Spectrom., 2020, 35, 2498
DOI: 10.1039/D0JA00323A

Elemental bio-imaging using laser ablation-triple quadrupole-ICP-MS

David P. Bishop, David Clases, Fred Fryer, Elizabeth Williams, Simon Wilkins, Dominic J. Hare, Nerida Cole, Uwe Karst and Philip A. Doble

J. Anal. At. Spectrom., 2016, 31, 197
DOI: 10.1039/C5JA00293A

A guide to integrating immunohistochemistry and chemical imaging

David P. Bishop, Nerida Cole, Tracy Zhang, Philip A. Doble and Dominic J. Hare

Chem. Soc. Rev., 2018, 47, 3770
DOI: 10.1039/C7CS00610A

Empirically derived formulae for calculation of age- and region-related levels of iron, copper and zinc in the adult C57BL/6 mouse brain

E. Suryana, B.D. Rowlands, D.P. Bishop, D.I. Finkelstein and K.L. Double

Neurobiology of Aging, 2024, 136, 34
DOI: 10.1016/j.neurobiolaging.2024.01.003

Electrostimulation in an autonomous culture lab-on-chip provides neuroprotection of a retinal explant from a retinitis pigmentosa mouse-model

Miguel Cabello, Marta Mozo, Berta De la Cerda, Carmen Aracil, Francisco J. Diaz-Corrales, Francisco Perdigones, Lourdes Valdes-Sanchez, Isabel Relimpio, Shom S. Bhattacharya and Jose Manuel Quero

Sensors and Actuators B: Chemical, 2019, 288, 337
DOI: 10.1016/j.snb.2019.02.118

A novel calibration strategy based on internal standard–spiked gelatine for quantitative bio-imaging by LA-ICP-MS: application to renal localization and quantification of uranium

Nagore Grijalba, Alexandre Legrand, Valerie Holler and Céline Bouvier-Capely

Anal Bioanal Chem, 2020, 412, 3113
DOI: 10.1007/s00216-020-02561-4

Alterations in zinc, copper, and iron levels in the retina and brain of Alzheimer's disease patients and the APP/PS1 mouse model

Seyed Mostafa Hosseinpour Mashkani, David P Bishop, Mika T Westerhausen, Paul A Adlard and S Mojtaba Golzan

Metallomics, 2024, 16
DOI: 10.1093/mtomcs/mfae053

Impact of Histological Processing on Endogenous Elemental Contents and Distributions in Breast Cancer Tissue Sections

Amy V. Lovejoy, Alexander P. Morrell, Diego Mesa, Alex Griffiths, Piotr R. Golda, Kay L. Dawson, Evie Wren, Katharina Kreissig, Charles Coombes, Mark Rehkämper and Rebekah E.T. Moore

Chemical & Biomedical Imaging, 2026
DOI: 10.1021/cbmi.5c00217

Elemental bioimaging of platinum in mouse tissues by laser ablation-inductively coupled plasma-mass spectrometry for the study of localization behavior of structurally similar complexes

Tsz-Shan Lum, Cheuk-Lam Ho, Yeuk-Ki Tsoi, Chi-Ho Siu, Patrick Ying-Kit Yue, Wai-Yeung Wong and Kelvin Sze-Yin Leung

International Journal of Mass Spectrometry, 2016, 404, 40
DOI: 10.1016/j.ijms.2016.05.005

Lipidomic Analysis of Mouse Brain to Evaluate the Efficacy and Preservation of Different Tissue Preparatory Techniques by IR-MALDESI-MSI

Mary F. Wang, Alexandria L. Sohn, Juhi Samal, Kevin Erning, Tatiana Segura and David C. Muddiman

J. Am. Soc. Mass Spectrom., 2023, 34, 869
DOI: 10.1021/jasms.2c00353

Bioimaging of metallothioneins in ocular tissue sections by laser ablation-ICP-MS using bioconjugated gold nanoclusters as specific tags

María Cruz-Alonso, Beatriz Fernandez, Lydia Álvarez, Héctor González-Iglesias, Heike Traub, Norbert Jakubowski and Rosario Pereiro

Microchim Acta, 2018, 185
DOI: 10.1007/s00604-017-2597-1

l‐3,4‐dihydroxyphenylalanine (l‐DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha‐synuclein mouse models of Parkinson's disease

Jessica L. Billings, Sarah L. Gordon, Tristan Rawling, Philip A. Doble, Ashley I. Bush, Paul A. Adlard, David I. Finkelstein and Dominic J. Hare

Journal of Neurochemistry, 2019, 150, 88
DOI: 10.1111/jnc.14676

Characterization of the spatial distribution of metals and profile of metalloprotein complexes in a mouse model of repetitive mild traumatic brain injury

Sydney M A Juan, Maria Daglas, Adam P Gunn, Larissa Lago and Paul A Adlard

Metallomics, 2022, 14
DOI: 10.1093/mtomcs/mfac092

MMP-11 as a biomarker for metastatic breast cancer by immunohistochemical-assisted imaging mass spectrometry

Raquel González de Vega, David Clases, María Luisa Fernández-Sánchez, Noemí Eiró, Luis O. González, Francisco J. Vizoso, Philip A. Doble and Alfredo Sanz-Medel

Anal Bioanal Chem, 2019, 411, 639
DOI: 10.1007/s00216-018-1365-3

Evaluation of combined workflows for multimodal mass spectrometry imaging of elements and lipids from the same tissue section

Tassiani Sarretto, Mika T. Westerhausen, Jayden C. Mckinnon, David P. Bishop and Shane R. Ellis

Anal Bioanal Chem, 2025, 417, 705
DOI: 10.1007/s00216-024-05696-w

Comparative analysis of sucrose-embedding for whole-body zebrafish MSI by IR-MALDESI

Mary F. Wang, Morgan M. Ritter, Seth W. Kullman and David C. Muddiman

Anal Bioanal Chem, 2023, 415, 6389
DOI: 10.1007/s00216-023-04914-1

Immunolabelling perturbs the endogenous and antibody-conjugated elemental concentrations during immuno-mass spectrometry imaging

Monique G. Mello, Mika T. Westerhausen, Thomas E. Lockwood, Prashina Singh, Jonathan Wanagat and David P. Bishop

Anal Bioanal Chem, 2024, 416, 2725
DOI: 10.1007/s00216-023-04967-2

A novel approach to quantify different iron forms in ex-vivo human brain tissue

Pravin Kumar, Marjolein Bulk, Andrew Webb, Louise van der Weerd, Tjerk H. Oosterkamp, Martina Huber and Lucia Bossoni

Sci Rep, 2016, 6
DOI: 10.1038/srep38916

Metal concentrations and distributions in the human olfactory bulb in Parkinson’s disease

Bronwen Gardner, Birger V. Dieriks, Steve Cameron, Lakshini H. S. Mendis, Clinton Turner, Richard L. M. Faull and Maurice A. Curtis

Sci Rep, 2017, 7
DOI: 10.1038/s41598-017-10659-6

Laser ablation-inductively coupled plasma-mass spectrometry imaging of white and gray matter iron distribution in Alzheimer's disease frontal cortex

Dominic J. Hare, Erika P. Raven, Blaine R. Roberts, Mirjana Bogeski, Stuart D. Portbury, Catriona A. McLean, Colin L. Masters, James R. Connor, Ashley I. Bush, Peter J. Crouch and Philip A. Doble

NeuroImage, 2016, 137, 124
DOI: 10.1016/j.neuroimage.2016.05.057

Iron, Copper, and Zinc Concentration in Aβ Plaques in the APP/PS1 Mouse Model of Alzheimer’s Disease Correlates with Metal Levels in the Surrounding Neuropil

Simon A. James, Quentin I. Churches, Martin D. de Jonge, Ian E. Birchall, Victor Streltsov, Gawain McColl, Paul A. Adlard and Dominic J. Hare

ACS Chem. Neurosci., 2017, 8, 629
DOI: 10.1021/acschemneuro.6b00362

Gadolinium Deposition in Human Brain Tissues after Contrast-enhanced MR Imaging in Adult Patients without Intracranial Abnormalities

Robert J. McDonald, Jennifer S. McDonald, David F. Kallmes, Mark E. Jentoft, Michael A. Paolini, David L. Murray, Eric E. Williamson and Laurence J. Eckel

Radiology, 2017, 285, 546
DOI: 10.1148/radiol.2017161595

Single cell–inductively coupled plasma–mass spectrometry (SC-ICP-MS) reveals metallic heterogeneity in a macrophage model of infectious diseases

Claire Davison, Jordan Pascoe, Melanie Bailey, Dany J. V. Beste and Mónica Felipe-Sotelo

Anal Bioanal Chem, 2024, 416, 6945
DOI: 10.1007/s00216-024-05592-3

Analysis of neuronal iron deposits in Parkinson's disease brain tissue by synchrotron x-ray spectromicroscopy

Jake Brooks, James Everett, Frederik Lermyte, Vindy Tjendana Tjhin, Peter J. Sadler, Neil Telling and Joanna F. Collingwood

Journal of Trace Elements in Medicine and Biology, 2020, 62, 126555
DOI: 10.1016/j.jtemb.2020.126555

Comparative Study of Metal Quantification in Neurological Tissue Using Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry Imaging and X-ray Fluorescence Microscopy

Katherine M. Davies, Dominic J. Hare, Sylvain Bohic, Simon A. James, Jessica L. Billings, David I. Finkelstein, Philip A. Doble and Kay L. Double

Anal. Chem., 2015, 87, 6639
DOI: 10.1021/acs.analchem.5b01454

Cortical Iron Reflects Severity of Alzheimer’s Disease

Sara van Duijn, Marjolein Bulk, Sjoerd G. van Duinen, Rob J.A. Nabuurs, Mark A. van Buchem, Louise van der Weerd and Remco Natté

JAD, 2017, 60, 1533
DOI: 10.3233/JAD-161143

Perfusion alters free zinc levels in the rodent brain

S.L.P. Lippi, K.M. Craven, C.M. Hernandez, G.M. Grant and J.M. Flinn

Journal of Neuroscience Methods, 2019, 315, 14
DOI: 10.1016/j.jneumeth.2018.12.018

Expanding the boundaries of atomic spectroscopy at the single-cell level: critical review of SP-ICP-MS, LIBS and LA-ICP-MS advances for the elemental analysis of tissues and single cells

Claire Davison, Dany Beste, Melanie Bailey and Mónica Felipe-Sotelo

Anal Bioanal Chem, 2023, 415, 6931
DOI: 10.1007/s00216-023-04721-8

Regional iron distribution and soluble ferroprotein profiles in the healthy human brain

Erin J. McAllum, Dominic J. Hare, Irene Volitakis, Catriona A. McLean, Ashley I. Bush, David I. Finkelstein and Blaine R. Roberts

Progress in Neurobiology, 2020, 186, 101744
DOI: 10.1016/j.pneurobio.2019.101744

A simple preparation protocol for shipping and storage of tissue sections for laser ablation-inductively coupled plasma-mass spectrometry imaging

Rebecca Buchholz, Sebastian Krossa, Maria K Andersen, Michael Holtkamp, Michael Sperling, Uwe Karst and May-Britt Tessem

Metallomics, 2022, 14
DOI: 10.1093/mtomcs/mfac013

Advances in mass spectrometry imaging for toxicological analysis and safety evaluation of pharmaceuticals

Yilin Chen, Yanqiao Xie, Linnan Li, Zhengtao Wang and Li Yang

Mass Spectrometry Reviews, 2023, 42, 2207
DOI: 10.1002/mas.21807

Exploratory LA-ICP-MS Imaging of Foliar-Applied Gold Nanoparticles and Nutrients in Lentil Leaves

Lucia Nemček, Martin Šebesta, Shadma Afzal, Michaela Bahelková, Tomáš Vaculovič, Jozef Kollár, Matúš Maťko and Ingrid Hagarová

Applied Sciences, 2026, 16, 974
DOI: 10.3390/app16020974

Commentary: Comments regarding Becker et al. (Analytica Chimica Acta, 835, 2014, 1–18)

Dominic J. Hare

Analytica Chimica Acta, 2017, 972, 12
DOI: 10.1016/j.aca.2017.03.042

Laser Ablation–Inductively Coupled Plasma–Mass Spectrometry Imaging in Biology

Philip A. Doble, Raquel Gonzalez de Vega, David P. Bishop, Dominic J. Hare and David Clases

Chem. Rev., 2021, 121, 11769
DOI: 10.1021/acs.chemrev.0c01219

Meta‐Analysis of Copper and Iron in Parkinson's Disease Brain and Biofluids

Sian Genoud, Alistair M. Senior, Dominic J. Hare and Kay L. Double

Movement Disorders, 2020, 35, 662
DOI: 10.1002/mds.27947

A New Method of Biostorage and Biopreservation for Human Amputated Extremities

Jia Luo, Hongkang Zhou, Libing Rao, Tianxiong Liu, Lian Liu, Yanliang Chen, Jianlong Wang, Tu Hu, Shiqi Liu, Dan Chen, Hui Wang, Leping Zeng and JuFang Huang

Biopreservation and Biobanking, 2018, 16, 251
DOI: 10.1089/bio.2017.0111

Ventral skull based approach to whole-brain extraction in mice

Alexandra N. Buntin-Nakamura and Daniel Quintana

MethodsX, 2026, 16, 103787
DOI: 10.1016/j.mex.2026.103787