Juliana Ferreira de Souza, Katiusca da Silva Pontes, Thais Francine Ribeiro Alves, Cecilia Torqueti de Barros, Venancio Alves Amaral, Kessi Marie de Moura Crescencio, Alessandra Candida Rios, Fernando Batain, Eliana Barbosa Souto, Patricia Severino, Daniel Komatsu, Moema de Alencar Hausen and Marco Vinícius Chaud

Journal of Molecular Liquids, 2020, 306, 112861
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A simple and effective method to improve bioavailability of glimepiride by utilizing hydrotropy technique

Haiying Li, Lilan Ma, Xiaxia Li, Xin Cui, Wenzhi Yang, Shigang Shen and Mingmao Chen

European Journal of Pharmaceutical Sciences, 2015, 77, 154
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Progress in the field of hydrotropy: mechanism, applications and green concepts

Akash D. Patel and Meghal A. Desai

Reviews in Chemical Engineering, 2023, 39, 601
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Role of Hydrotropes in Sparingly Soluble Drug Solubilization: Insight from a Molecular Dynamics Simulation and Experimental Perspectives

Rabindranath Paul, Krishna Gopal Chattaraj and Sandip Paul

Langmuir, 2021, 37, 4745
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Solubility-Enhancing Hydrotrope Electrolyte with Tailor-Made Organic Redox-Active Species for Redox-Enhanced Electrochemical Capacitors

Jinhwan Byeon, Jinhyuck Ko, Subin Lee, Da Hye Kim, Sung Won Kim, Dowon Kim, Wangsuk Oh, Sukwon Hong and Seung Joon Yoo

ACS Energy Lett., 2023, 8, 2345
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Laboratory experiment on a toluene-polydimethyl silicone thickened supercritical carbon dioxide fracturing fluid

Mingyong Du, Xin Sun, Caili Dai, Hao Li, Tao Wang, Zhongliang Xu, Mingwei Zhao, Baoshan Guan and Ping Liu

Journal of Petroleum Science and Engineering, 2018, 166, 369
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Interactions in Water–Ionic Liquid Mixtures: Comparing Protic and Aprotic Systems

Joshua E. S. J. Reid, Richard J. Gammons, John M. Slattery, Adam J. Walker and Seishi Shimizu

J. Phys. Chem. B, 2017, 121, 599
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Synergistic Solvation as the Enhancement of Local Mixing

Seishi Shimizu and Nobuyuki Matubayasi

J. Phys. Chem. B, 2024, 128, 5713
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Supramolecular systems based on hydrotropes, their analogues and mixtures with typical surfactants. Structural behavior, enhanced solubilization and viscosity properties

Farida G. Valeeva, Elmira A. Vasilieva, Gulnara A. Gaynanova, Ruslan R. Kashapov, Sergey V. Zakharov, Dmitry A. Kuryashov, Svetlana S. Lukashenko, Natalia Yu. Bashkirtseva and Lucia Ya. Zakharova

Journal of Molecular Liquids, 2015, 203, 104
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Intensive nature of fluctuations: Reconceptualizing Kirkwood-Buff theory via elementary algebra

Seishi Shimizu and Nobuyuki Matubayasi

Journal of Molecular Liquids, 2020, 318, 114225
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Mechanism of dye solubilization and de-aggregation by urea

James M. Perry, Yu Nagai Kanasaki, Peter B. Karadakov and Seishi Shimizu

Dyes and Pigments, 2021, 193, 109530
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Solubility-Permeability Interplay of Hydrotropic Solubilization Using Response Surface Methodology

Nidhi Nainwal, Sunil Jawala, Ranjit Singh and Vikas A. Saharan

DDL, 2020, 10, 209
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A unified perspective on preferential solvation and adsorption based on inhomogeneous solvation theory

Seishi Shimizu and Nobuyuki Matubayasi

Physica A: Statistical Mechanics and its Applications, 2018, 492, 1988
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Hydrotropes

Werner Kunz, Krister Holmberg and Thomas Zemb

Current Opinion in Colloid & Interface Science, 2016, 22, 99
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Statistical thermodynamics of casein aggregation: Effects of salts and water

Kaja Harton and Seishi Shimizu

Biophysical Chemistry, 2019, 247, 34
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Solubility-enabling formulations for oral delivery of lipophilic drugs: considering the solubility-permeability interplay for accelerated formulation development

Noa Fine-Shamir and Arik Dahan

Expert Opinion on Drug Delivery, 2024, 21, 13
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Aggregation Behavior and Thermodynamic Studies of Hydrotropes: A Review

Akash D. Patel and Meghal A. Desai

Tenside Surfactants Detergents, 2020, 57, 192
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Statistical thermodynamics of regular solutions and solubility parameters

Seishi Shimizu and Nobuyuki Matubayasi

Journal of Molecular Liquids, 2019, 273, 626
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Enhanced Solubility of Lignin Monomeric Model Compounds and Technical Lignins in Aqueous Solutions of Deep Eutectic Solvents

Belinda Soares, Daniel J. P. Tavares, José Luis Amaral, Armando J. D. Silvestre, Carmen S. R. Freire and João A. P. Coutinho

ACS Sustainable Chem. Eng., 2017, 5, 4056
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Effect of solute aggregation on solubilization

Seishi Shimizu and Yu Nagai Kanasaki

Journal of Molecular Liquids, 2019, 274, 209
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Adsorbate-adsorbate interactions on microporous materials

Seishi Shimizu and Nobuyuki Matubayasi

Microporous and Mesoporous Materials, 2021, 323, 111254
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Hydrotropy: Monomer–Micelle Equilibrium and Minimum Hydrotrope Concentration

Seishi Shimizu and Nobuyuki Matubayasi

J. Phys. Chem. B, 2014, 118, 10515
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On the use of linear model-based optimization to obtain optimum solubility permeability balance (OSPB) in cinnarizine-hydrotropic blends

Bhakti Mahendra Pawar, Abhinab Goswami, Syed Nazrin Ruhina Rahman, Amoolya Sree and Tamilvanan Shunmugaperumal

Journal of Molecular Liquids, 2023, 381, 121817
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The mechanism of salt effects on starch gelatinization from a statistical thermodynamic perspective

Thomas W.J. Nicol, Noriyuki Isobe, James H. Clark, Nobuyuki Matubayasi and Seishi Shimizu

Food Hydrocolloids, 2019, 87, 593
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Gelation: The Role of Sugars and Polyols on Gelatin and Agarose

Seishi Shimizu and Nobuyuki Matubayasi

J. Phys. Chem. B, 2014, 118, 13210
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Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt

Peter Keša, Daniel Jancura, Júlia Kudláčová, Eva Valušová and Marián Antalík

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2018, 193, 185
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Hydrotropic Solubilization of Lipophilic Drugs for Oral Delivery: The Effects of Urea and Nicotinamide on Carbamazepine Solubility–Permeability Interplay

Avital Beig, David Lindley, Jonathan M. Miller, Riad Agbaria and Arik Dahan

Front. Pharmacol., 2016, 7
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How Entrainers Enhance Solubility in Supercritical Carbon Dioxide

Seishi Shimizu and Steven Abbott

J. Phys. Chem. B, 2016, 120, 3713
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Implicit function theorem and Jacobians in solvation and adsorption

Seishi Shimizu and Nobuyuki Matubayasi

Physica A: Statistical Mechanics and its Applications, 2021, 570, 125801
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Recovery of Syringic Acid from Industrial Food Waste with Aqueous Solutions of Ionic Liquids

Emanuelle L. P. de Faria, Ana M. Ferreira, Ana Filipa M. Cláudio, João A. P. Coutinho, Armando J. D. Silvestre and Mara G. Freire

ACS Sustainable Chem. Eng., 2019, 7, 14143
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Atomic view of cosolute-induced protein denaturation probed by NMR solvent paramagnetic relaxation enhancement

Yusuke Okuno, Janghyun Yoo, Charles D. Schwieters, Robert B. Best, Hoi Sung Chung and G. Marius Clore

Proc. Natl. Acad. Sci. U.S.A., 2021, 118
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Kirkwood-Buff Analysis of Binary and Ternary Systems Consisting of Alcohols (Methanol, Ethanol, 1-Propanol, and 2-Propanol), Water, and n-Hexane to Understand the Formation of Surfactant-Free Microemulsions

Seungmin Seo, Hong-shik Lee and Tae Jun Yoon

J. Phys. Chem. B, 2024, 128, 5092
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RISM-assisted analysis of role of alkali metal hydroxides in the solvation of cellulose in alkali/urea aqueous solutions

Eugene Huh, Ji-Hyun Yang, Chang-Ha Lee, Ik-Sung Ahn and Byung Jin Mhin

Cellulose, 2021, 28, 11247
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Enhanced solubilization in multi-component mixtures: Mechanism of synergistic amplification of cyclodextrin solubility by urea and inorganic salts

Ilan Shumilin and Daniel Harries

Journal of Molecular Liquids, 2023, 380, 121760
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A shell-resolved analysis of preferential solvation of coffee ingredients in aqueous mixtures of the ionic liquid 1-ethyl-3-methylimidazolium acetate

Veronika Zeindlhofer, Magdalena Berger, Othmar Steinhauser and Christian Schröder

The Journal of Chemical Physics, 2018, 148
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Hydrotropes: Solubilization of nonpolar compounds and modification of surfactant solutions

Lucia Ya. Zakharova, Elmira A. Vasilieva, Alla B. Mirgorodskaya, Sergey V. Zakharov, Rais V. Pavlov, Nadezda E. Kashapova and Gulnara A. Gaynanova

Journal of Molecular Liquids, 2023, 370, 120923
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The Solubility-Permeability Interplay for Solubility-Enabling Oral Formulations

Nidhi Nainwal, Ranjit Singh, Sunil Jawla and Vikas Anand Saharan

CDT, 2019, 20, 1434
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How Sugars Modify Caffeine Self-Association and Solubility: Resolving a Mechanism of Selective Hydrotropy

Ilan Shumilin, Christoph Allolio and Daniel Harries

J. Am. Chem. Soc., 2019, 141, 18056
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Characterizing the Effects of a “Switchable Water” Additive on the Aqueous Solubility of Small Molecules

Jesse R. Vanderveen, Sarika Burra, Jialing Geng, Alexandre Goyon, Alexander Jardine, Hyejin E. Shin, Tamer Andrea, Paul J. Dyson and Philip G. Jessop

ChemPhysChem, 2018, 19, 2093
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Hydrotropic Antisolvent Crystallization for the Reduction in the Particle Size of Methylcobalamin

Akash D. Patel and Meghal A. Desai

ACS Sustainable Chem. Eng., 2023, 11, 6250
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Computer Simulation Studies of the Mechanism of Hydrotrope-Assisted Solubilization of a Sparingly Soluble Drug Molecule

Shubhadip Das and Sandip Paul

J. Phys. Chem. B, 2016, 120, 3540
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Acoustic Properties of Antibacterial Pyridoxine and Neomycin Drugs in Aqueous-Urea Solutions at (T = 303.15, 308.15, and 313.15 K)

S. D. Deosarkar, M. P. Pawar, A. D. Arsule and H. N. Pawar

Russ. J. Phys. Chem., 2025, 99, 2297
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Elucidating the Solubility Enhancement of Active Pharmaceutical Ingredients through Hydrotropy: A Case of Local Anesthetics

Sahar Nasrallah, Alexander Wendler, Sebastian A. Hallweger, Gregor Kieslich and Mirjana Minceva

Mol. Pharmaceutics, 2025, 22, 4953
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Gastrophysics: Statistical thermodynamics of biomolecular denaturation and gelation from the Kirkwood-Buff theory towards the understanding of tofu

Seishi Shimizu, Richard Stenner and Nobuyuki Matubayasi

Food Hydrocolloids, 2017, 62, 128
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Cholinium-based ionic liquids as bioinspired hydrotropes to tackle solubility challenges in drug formulation

Tânia E. Sintra, Dinis O. Abranches, Jordana Benfica, Bruna P. Soares, Sónia P.M. Ventura and João A.P. Coutinho

European Journal of Pharmaceutics and Biopharmaceutics, 2021, 164, 86
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Temperature Dependence of Hydrotropy

Seishi Shimizu and Nobuyuki Matubayasi

J. Phys. Chem. B, 2024, 128, 10915
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Co‐surfactant, co‐solvent, and hydrotropic properties of some common cooling agents

Valeria Larcinese‐Hafner and Vera Tchakalova

Flavour & Fragrance J, 2018, 33, 303
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Facile Strategy Enabling Both High Loading and High Release Amounts of the Water-Insoluble Drug Clofazimine Using Mesoporous Silica Nanoparticles

Wei Chen, Chi-An Cheng, Bai-Yu Lee, Daniel L. Clemens, Wen-Yen Huang, Marcus A. Horwitz and Jeffrey I. Zink

ACS Appl. Mater. Interfaces, 2018, 10, 31870
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Data-Centric Development of Lignin Structure–Solubility Relationships in Deep Eutectic Solvents Using Molecular Simulations

Zeynep Sumer and Reid C. Van Lehn

ACS Sustainable Chem. Eng., 2022, 10, 10144
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Enhancing Artemisinin Solubility in Aqueous Solutions: Searching for Hydrotropes based on Ionic Liquids

Isabela Sales, Dinis O. Abranches, Pedro Costa, Tânia E. Sintra, Sónia P.M. Ventura, Silvana Mattedi, João A.P. Coutinho, Mara G. Freire and Simão P. Pinho

Fluid Phase Equilibria, 2021, 534, 112961
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