Introducing BPA-equivalents: assessing mixture toxicity and substitution of BPA in environmental exposure scenarios

Vanessa Srebny, Georg Braun, Niklas Wojtysiak and Beate. I. Escher

Environ. Sci.: Processes Impacts, 2026
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Evaluation of reverse osmosis drinking water treatment of riverbank filtrate using bioanalytical tools and non-target screening

Vittorio Albergamo, Beate I. Escher, Emma L. Schymanski, Rick Helmus, Milou M. L. Dingemans, Emile R. Cornelissen, Michiel H. S. Kraak, Juliane Hollender and Pim de Voogt

Environ. Sci.: Water Res. Technol., 2020, 6, 103
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Exploring the oxidative stress response mechanism triggered by environmental water samples

Peta A. Neale, Maud E. S. Achard, Beate I. Escher and Frederic D. L. Leusch

Environ. Sci.: Processes Impacts, 2017, 19, 1126
DOI: 10.1039/C6EM00541A

Application of cell-based bioassays to evaluate treatment efficacy of conventional and intensified treatment wetlands

Jaime Nivala, Peta A. Neale, Tobias Haasis, Stefanie Kahl, Maria König, Roland A. Müller, Thorsten Reemtsma, Rita Schlichting and Beate I. Escher

Environ. Sci.: Water Res. Technol., 2018, 4, 206
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Point-of-use water filters can effectively remove disinfection by-products and toxicity from chlorinated and chloraminated tap water

Daniel Stalter, Elissa O'Malley, Urs von Gunten and Beate I. Escher

Environ. Sci.: Water Res. Technol., 2016, 2, 875
DOI: 10.1039/C6EW00068A

Characterizing the marine mammal exposome by iceberg modeling, linking chemical analysis and in vitro bioassays

Eva B. Reiter, Beate I. Escher, Elisa Rojo-Nieto, Hannah Nolte, Ursula Siebert and Annika Jahnke

Environ. Sci.: Processes Impacts, 2023, 25, 1802
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Solid-phase extraction as sample preparation of water samples for cell-based and otherin vitrobioassays

Peta A. Neale, Werner Brack, Selim Aït-Aïssa, Wibke Busch, Juliane Hollender, Martin Krauss, Emmanuelle Maillot-Maréchal, Nicole A. Munz, Rita Schlichting, Tobias Schulze, Bernadette Vogler and Beate I. Escher

Environ. Sci.: Processes Impacts, 2018, 20, 493
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Selective removal of natural organic matter during drinking water production changes the composition of disinfection by-products

Anna Andersson, Elin Lavonen, Mourad Harir, Michael Gonsior, Norbert Hertkorn, Philippe Schmitt-Kopplin, Henrik Kylin and David Bastviken

Environ. Sci.: Water Res. Technol., 2020, 6, 779
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Emerging investigator series: effect-based characterization of mixtures of environmental pollutants in diverse sediments

Annika Jahnke, Anna Sobek, Melanie Bergmann, Jennifer Bräunig, Madlen Landmann, Sabine Schäfer and Beate I. Escher

Environ. Sci.: Processes Impacts, 2018, 20, 1667
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Mixture effects of drinking water disinfection by-products: implications for risk assessment

Daniel Stalter, Elissa O'Malley, Urs von Gunten and Beate I. Escher

Environ. Sci.: Water Res. Technol., 2020, 6, 2341
DOI: 10.1039/C9EW00988D

Application ofin vitrobioassays for water quality monitoring in three drinking water treatment plants using different treatment processes including biological treatment, nanofiltration and ozonation coupled with disinfection

Peta A. Neale, Cedric Feliers, Lisa Glauch, Maria König, Caroline Lecarpentier, Rita Schlichting, Sylvie Thibert and Beate I. Escher

Environ. Sci.: Water Res. Technol., 2020, 6, 2444
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Water quality monitoring with in vitro bioassays to compare untreated oil sands process-affected water with unimpacted rivers

Kia Barrow, Beate I. Escher, Keegan A. Hicks, Maria König, Rita Schlichting and Maricor J. Arlos

Environ. Sci.: Water Res. Technol., 2023, 9, 2008
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Molecular changes among non-volatile disinfection by-products between drinking water treatment and consumer taps

Anna Andersson, Michael Gonsior, Mourad Harir, Norbert Hertkorn, Philippe Schmitt-Kopplin, Leanne Powers, Henrik Kylin, Daniel Hellström, Kerstin Nilsson, Ämma Pettersson, Helena Stavklint and David Bastviken

Environ. Sci.: Water Res. Technol., 2021, 7, 2335
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Cellular Metabolism in High-Throughput In Vitro Reporter Gene Assays and Implications for the Quantitative In Vitro–In Vivo Extrapolation

Fabian C. Fischer, Cedric Abele, Luise Henneberger, Nils Klüver, Maria König, Marie Mühlenbrink, Rita Schlichting and Beate I. Escher

Chem. Res. Toxicol., 2020, 33, 1770
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Water Quality Monitoring with the Multiplexed Assay MitoOxTox for Mitochondrial Toxicity, Oxidative Stress Response, and Cytotoxicity in AREc32 Cells

Jungeun Lee, Maria König, Georg Braun and Beate I. Escher

Environ. Sci. Technol., 2024, 58, 5716
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Integrating chemical analysis and bioanalysis to evaluate the contribution of wastewater effluent on the micropollutant burden in small streams

Peta A. Neale, Nicole A. Munz, Selim Aїt-Aїssa, Rolf Altenburger, François Brion, Wibke Busch, Beate I. Escher, Klára Hilscherová, Cornelia Kienle, Jiří Novák, Thomas-Benjamin Seiler, Ying Shao, Christian Stamm and Juliane Hollender

Science of The Total Environment, 2017, 576, 785
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Effects of Chemicals in Reporter Gene Bioassays with Different Metabolic Activities Compared to Baseline Toxicity

Julia Huchthausen, Jenny Braasch, Beate I. Escher, Maria König and Luise Henneberger

Chem. Res. Toxicol., 2024, 37, 744
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Disruption of Lipid Membrane Integrity by Synthetic Water-Soluble Polymers: Effects of Lipid Headgroup

Jiwon Park, Eunhye Bae, Hee-Jin Park, Yeonjeong Ha, Beate I. Escher and Jung-Hwan Kwon

Environ. Sci. Technol., 2026, 60, 4671
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Cytotoxicity of leachate from the final disposal of water treatment plant sludge

Mirella Bianca Gama de Almeida, Amanda Maria Dantas de Jesus, Adriane Xavier de Morais, Renata Falchete do Prado and Fabiana Alves Fiore

Cleaner Water, 2025, 4, 100099
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Effect-based monitoring of the Danube River using mobile passive sampling

Jiří Novák, Branislav Vrana, Tatsiana Rusina, Krzysztof Okonski, Roman Grabic, Peta A. Neale, Beate I. Escher, Miroslava Macová, Selim Ait-Aissa, Nicolas Creusot, Ian Allan and Klára Hilscherová

Science of The Total Environment, 2018, 636, 1608
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Effect-Based Water Quality Assessment in an Urban Tributary under Base Flow and Storm Conditions

Cassandra Rauert, Maria König, Peta A. Neale, Kevin V. Thomas and Beate I. Escher

Environ. Sci. Technol. Lett., 2024, 11, 1314
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Mixture effects in samples of multiple contaminants – An inter-laboratory study with manifold bioassays

Rolf Altenburger, Martin Scholze, Wibke Busch, Beate I. Escher, Gianina Jakobs, Martin Krauss, Janet Krüger, Peta A. Neale, Selim Ait-Aissa, Ana Catarina Almeida, Thomas-Benjamin Seiler, François Brion, Klára Hilscherová, Henner Hollert, Jiří Novák, Rita Schlichting, Hélène Serra, Ying Shao, Andrew Tindall, Knut Erik Tollefsen, Gisela Umbuzeiro, Tim D. Williams and Andreas Kortenkamp

Environment International, 2018, 114, 95
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Impact of sample acidification and extract storage on hormone receptor-mediated and oxidative stress activities in wastewater

Maria Yu, Geeta Mandava, Elin Lavonen, Agneta Oskarsson and Johan Lundqvist

Journal of Water and Health, 2024, 22, 169
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Comparison of Oxidants Used in Advanced Oxidation for Potable Reuse: Non-Target Analysis and Bioassays

Mingrui Song, Elizabeth McKenna, Imma Ferrer, E. Michael Thurman, Liz Taylor-Edmonds, Ronald Hofmann, Kenneth P. Ishida, Shannon L. Roback, Megan H. Plumlee and David Hanigan

ACS EST Water, 2023, 3, 690
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Development and application of species-specific cell-based bioassays to assess toxicity in green sea turtles

Kimberly A. Finlayson, Christine A. Madden Hof and Jason P. van de Merwe

Science of The Total Environment, 2020, 747, 142095
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Cytotoxicity of binary mixtures of human pharmaceuticals in a fish cell line: Approaches for non-monotonic concentration–response relationships

Peter A. Bain and Anupama Kumar

Chemosphere, 2014, 108, 334
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Toxicity bioassays with concentrated cell culture media—a methodology to overcome the chemical loss by conventional preparation of water samples

Frida Niss, Anna Kjerstine Rosenmai, Geeta Mandava, Stefan Örn, Agneta Oskarsson and Johan Lundqvist

Environ Sci Pollut Res, 2018, 25, 12183
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Innovative drinking water treatment techniques reduce the disinfection-induced oxidative stress and genotoxic activity

Johan Lundqvist, Anna Andersson, Anders Johannisson, Elin Lavonen, Geeta Mandava, Henrik Kylin, David Bastviken and Agneta Oskarsson

Water Research, 2019, 155, 182
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In Vitro Cytotoxicity and Adaptive Stress Responses to Selected Haloacetic Acid and Halobenzoquinone Water Disinfection Byproducts

Erik Procházka, Beate I. Escher, Michael J. Plewa and Frederic D. L. Leusch

Chem. Res. Toxicol., 2015, 28, 2059
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Towards reducing DBP formation potential of drinking water by favouring direct ozone over hydroxyl radical reactions during ozonation

Glen Andrew De Vera, Daniel Stalter, Wolfgang Gernjak, Howard S. Weinberg, Jurg Keller and Maria José Farré

Water Research, 2015, 87, 49
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Combining in vitro reporter gene bioassays with chemical analysis to assess changes in the water quality along the Ammer River, Southwestern Germany

Maximilian E. Müller, Beate I. Escher, Marc Schwientek, Martina Werneburg, Christiane Zarfl and Christian Zwiener

Environ Sci Eur, 2018, 30
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Storm Event–Driven Occurrence and Transport of Dissolved and Sorbed Organic Micropollutants and Associated Effects in the Ammer River, Southwestern Germany

Maximilian E. Müller, Christian Zwiener and Beate I. Escher

Environmental Toxicology and Chemistry, 2020, 40, 88
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Impact of various aeration strategies on the removal of micropollutants and biological effects in aerated horizontal flow treatment wetlands

Nadine A. Sossalla, Jaime Nivala, Beate I. Escher, Rita Schlichting, Manfred van Afferden, Roland A. Müller and Thorsten Reemtsma

Science of The Total Environment, 2022, 828, 154423
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Effect-directed analysis supporting monitoring of aquatic environments — An in-depth overview

Werner Brack, Selim Ait-Aissa, Robert M. Burgess, Wibke Busch, Nicolas Creusot, Carolina Di Paolo, Beate I. Escher, L. Mark Hewitt, Klara Hilscherova, Juliane Hollender, Henner Hollert, Willem Jonker, Jeroen Kool, Marja Lamoree, Matthias Muschket, Steffen Neumann, Pawel Rostkowski, Christoph Ruttkies, Jennifer Schollee, Emma L. Schymanski, Tobias Schulze, Thomas-Benjamin Seiler, Andrew J. Tindall, Gisela De Aragão Umbuzeiro, Branislav Vrana and Martin Krauss

Science of The Total Environment, 2016, 544, 1073
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In vitro bioassays to assess drinking water quality

Peta A. Neale and Beate I. Escher

Current Opinion in Environmental Science & Health, 2019, 7, 1
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Assessment of bioactive chemicals in wastewater effluents and surface waters using in vitro bioassays in the Nakdong River basin, Korea

Yegyun Choi, Chang-Dong Seo, Woorim Lee, Heejong Son and Yunho Lee

Chemosphere, 2024, 347, 140621
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Headspace-Free Setup of in Vitro Bioassays for the Evaluation of Volatile Disinfection By-Products

Daniel Stalter, Mriga Dutt and Beate I. Escher

Chem. Res. Toxicol., 2013, 26, 1605
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Antioxidant response elements: Discovery, classes, regulation and potential applications

Azhwar Raghunath, Kiruthika Sundarraj, Raju Nagarajan, Frank Arfuso, Jinsong Bian, Alan P. Kumar, Gautam Sethi and Ekambaram Perumal

Redox Biology, 2018, 17, 297
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A Tiered Approach for Screening and Assessment of Environmental Mixtures by Omics and In Vitro Assays

Wendi Fang, Ying Peng, Lu Yan, Pu Xia and Xiaowei Zhang

Environ. Sci. Technol., 2020, 54, 7430
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Nitriles as main products from the oxidation of primary amines by ferrate(VI): Kinetics, mechanisms and toxicological implications for nitrogenous disinfection byproduct control

Valentin Rougé, Jaedon Shin, Pham Thi Thai Ha Nguyen, Dong Jang, Woongbae Lee, Beate I. Escher and Yunho Lee

Water Research, 2022, 209, 117881
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Baseline Toxicity and Volatility Cutoff in Reporter Gene Assays Used for High-Throughput Screening

Beate I. Escher, Lisa Glauch, Maria König, Philipp Mayer and Rita Schlichting

Chem. Res. Toxicol., 2019, 32, 1646
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Future water quality monitoring — Adapting tools to deal with mixtures of pollutants in water resource management

Rolf Altenburger, Selim Ait-Aissa, Philipp Antczak, Thomas Backhaus, Damià Barceló, Thomas-Benjamin Seiler, Francois Brion, Wibke Busch, Kevin Chipman, Miren López de Alda, Gisela de Aragão Umbuzeiro, Beate I. Escher, Francesco Falciani, Michael Faust, Andreas Focks, Klara Hilscherova, Juliane Hollender, Henner Hollert, Felix Jäger, Annika Jahnke, Andreas Kortenkamp, Martin Krauss, Gregory F. Lemkine, John Munthe, Steffen Neumann, Emma L. Schymanski, Mark Scrimshaw, Helmut Segner, Jaroslav Slobodnik, Foppe Smedes, Subramaniam Kughathas, Ivana Teodorovic, Andrew J. Tindall, Knut Erik Tollefsen, Karl-Heinz Walz, Tim D. Williams, Paul J. Van den Brink, Jos van Gils, Branislav Vrana, Xiaowei Zhang and Werner Brack

Science of The Total Environment, 2015, 512-513, 540
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In vitro bioanalysis of drinking water from source to tap

Anna Kjerstine Rosenmai, Johan Lundqvist, Théo le Godec, Åsa Ohlsson, Rikard Tröger, Björn Hellman and Agneta Oskarsson

Water Research, 2018, 139, 272
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Combining analytical and in vitro techniques for comprehensive assessments of chemical exposure and effect in green sea turtles (Chelonia mydas)

Kimberly A. Finlayson, Frederic D.L. Leusch, Cesar A. Villa, Colin J. Limpus and Jason P. van de Merwe

Chemosphere, 2021, 274, 129752
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Combination of effect-based monitoring and targeted screening of (drinking)water II: Effect directed analysis of compounds responsible for bioassay activity

Corine J. Houtman, Carla van der Neut-Marchand, Yvonne G.M. van Oorschot, Marja H. Lamoree and Ruud J.C.A. Steen

Environment International, 2025, 205, 109782
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Effect-based trigger values for in vitro and in vivo bioassays performed on surface water extracts supporting the environmental quality standards (EQS) of the European Water Framework Directive

Beate I. Escher, Selim Aїt-Aїssa, Peter A. Behnisch, Werner Brack, François Brion, Abraham Brouwer, Sebastian Buchinger, Sarah E. Crawford, David Du Pasquier, Timo Hamers, Karina Hettwer, Klára Hilscherová, Henner Hollert, Robert Kase, Cornelia Kienle, Andrew J. Tindall, Jochen Tuerk, Ron van der Oost, Etienne Vermeirssen and Peta A. Neale

Science of The Total Environment, 2018, 628-629, 748
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Bioanalytical Assessment of the Formation of Disinfection Byproducts in a Drinking Water Treatment Plant

Peta A. Neale, Alice Antony, Michael E. Bartkow, Maria José Farré, Anna Heitz, Ina Kristiana, Janet Y. M. Tang and Beate I. Escher

Environ. Sci. Technol., 2012, 46, 10317
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Towards Mass Spectrometry-Based Chemical Exposome: Current Approaches, Challenges, and Future Directions

Jingchuan Xue, Yunjia Lai, Chih-Wei Liu and Hongyu Ru

Toxics, 2019, 7, 41
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Quantification of freely dissolved effect concentrations in in vitro cell-based bioassays

Luise Henneberger, Marie Mühlenbrink, Maria König, Rita Schlichting, Fabian C. Fischer and Beate I. Escher

Arch Toxicol, 2019, 93, 2295
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Development of an oxidative stress in vitro assay in zebrafish (Danio rerio) cell lines

Sebastian Lungu-Mitea, Agneta Oskarsson and Johan Lundqvist

Sci Rep, 2018, 8
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In vitro bioassays for quantifying mixture effects of organic micropollutants extracted from caged fish, water, and sediment

Beate I Escher, Brett R Blackwell, Jenna Cavallin, Janek P Dann, Annika Jahnke, Correne Jenson, Kathleen Jensen, Michael Kahl, Martin Krauss, Maria König, Peta A Neale, Stefan Scholz, Dan Villeneuve and Gerald T Ankley

Environmental Toxicology and Chemistry, 2026, 45, 137
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Haloacetonitriles Induce Structure-Related Cellular Toxicity Through Distinct Proteome Thiol Reaction Mechanisms

Kirsten Yeung, Linna Xie, Pranav Nair and Hui Peng

ACS Environ. Au, 2025, 5, 101
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In vitro bioassays for monitoring drinking water quality of tap water, domestic filtration and bottled water

Beate I. Escher, Jordi Blanco, Josep Caixach, Dora Cserbik, Maria J. Farré, Cintia Flores, Maria König, Jungeun Lee, Jo Nyffeler, Carles Planas, Paula E. Redondo-Hasselerharm, Joaquim Rovira, Josep Sanchís, Marta Schuhmacher and Cristina M. Villanueva

J Expo Sci Environ Epidemiol, 2024, 34, 126
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Bioanalytical and chemical assessment of the disinfection by-product formation potential: Role of organic matter

Maria José Farré, Sophie Day, Peta A. Neale, Daniel Stalter, Janet Y.M. Tang and Beate I. Escher

Water Research, 2013, 47, 5409
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Most Oxidative Stress Response In Water Samples Comes From Unknown Chemicals: The Need For Effect-Based Water Quality Trigger Values

Beate I. Escher, Charlotte van Daele, Mriga Dutt, Janet Y. M. Tang and Rolf Altenburger

Environ. Sci. Technol., 2013, 47, 7002
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In vitro bioassays to evaluate complex chemical mixtures in recycled water

Ai Jia, Beate I. Escher, Frederic D.L. Leusch, Janet Y.M. Tang, Erik Prochazka, Bingfeng Dong, Erin M. Snyder and Shane A. Snyder

Water Research, 2015, 80, 1
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Which chemicals drive biological effects in wastewater and recycled water?

Janet Y.M. Tang, Francesco Busetti, Jeffrey W.A. Charrois and Beate I. Escher

Water Research, 2014, 60, 289
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Using Pgst-4::GFP-transformed Caenorhabditis elegans for drinking water quality monitoring

Yan Wang, Xue Han, Jie Zhang, Meng-Xuan Zhou and Ai-Lin Liu

Environ Monit Assess, 2023, 195
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Pelagic and coastal green turtles (Chelonia mydas) experience differences in chemical exposure and effect

Grace E. Perkins, Kimberly A. Finlayson and Jason P. van de Merwe

Marine Pollution Bulletin, 2022, 183, 114027
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Wastewater treatment efficacy evaluated with in vitro bioassays

Peta A. Neale, Jake W. O’Brien, Lisa Glauch, Maria König, Martin Krauss, Jochen F. Mueller, Ben Tscharke and Beate I. Escher

Water Research X, 2020, 9, 100072
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Fingerprinting the reactive toxicity pathways of 50 drinking water disinfection by-products

Daniel Stalter, Elissa O'Malley, Urs von Gunten and Beate I. Escher

Water Research, 2016, 91, 19
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Bioanalytical evidence that chemicals in tattoo ink can induce adaptive stress responses

Peta A. Neale, Daniel Stalter, Janet Y.M. Tang and Beate I. Escher

Journal of Hazardous Materials, 2015, 296, 192
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Experimental exposure assessment of designed chemical mixtures in cell-based in vitro bioassays

Luise Henneberger, Julia Huchthausen, Maria König, Alina Menge, Niklas Wojtysiak and Beate I. Escher

Front. Environ. Chem., 2022, 3
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In vitro bioanalytical evaluation of removal efficiency for bioactive chemicals in Swedish wastewater treatment plants

Johan Lundqvist, Geeta Mandava, Sebastian Lungu-Mitea, Foon Yin Lai and Lutz Ahrens

Sci Rep, 2019, 9
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Beyond Estrogenicity: A Comparative Assessment of Bisphenol A and Its Alternatives in In Vitro Assays Questions Safety of Replacements

Vanessa Srebny, Luise Henneberger, Maria König, Julia Huchthausen, Jenny Braasch and Beate I. Escher

Environ. Sci. Technol., 2025, 59, 17457
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Thiol Reactome: A Nontargeted Strategy to Precisely Identify Thiol Reactive Drinking Water Disinfection Byproducts

Kirsten Yeung, Nathan Moore, Jianxian Sun, Lizbeth Taylor-Edmonds, Susan Andrews, Ronald Hofmann and Hui Peng

Environ. Sci. Technol., 2023, 57, 18722
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Effect-based evaluation of water quality in a system of indirect reuse of wastewater for drinking water production

Kim Frieberg, Pablo Gago-Ferrero, Lubertus Bijlsma, Lutz Ahrens, Karin Wiberg, Félix Hernández, Agneta Oskarsson and Johan Lundqvist

Water Research, 2023, 242, 120147
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Bioanalytical effect-balance model to determine the bioavailability of organic contaminants in sediments affected by black and natural carbon

Jennifer Bräunig, Janet Y.M. Tang, Michael St. J. Warne and Beate I. Escher

Chemosphere, 2016, 156, 181
DOI: 10.1016/j.chemosphere.2016.04.056

Linking in Vitro Effects and Detected Organic Micropollutants in Surface Water Using Mixture-Toxicity Modeling

Peta A. Neale, Selim Ait-Aissa, Werner Brack, Nicolas Creusot, Michael S. Denison, Björn Deutschmann, Klára Hilscherová, Henner Hollert, Martin Krauss, Jiří Novák, Tobias Schulze, Thomas-Benjamin Seiler, Helene Serra, Ying Shao and Beate I. Escher

Environ. Sci. Technol., 2015, 49, 14614
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Toward the Proactive Design of Sustainable Chemicals: Ionic Liquids as a Prime Example

Stephan Beil, Marta Markiewicz, Cristina Silva Pereira, Piotr Stepnowski, Jorg Thöming and Stefan Stolte

Chem. Rev., 2021, 121, 13132
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Sequential exposure to anoxic/oxic conditions leads to biotransformation and reduced sitagliptin toxicity in urban hyporheic zones

Simon Klaes, Kerstin Gerundt, Darja Deobald, Luise Henneberger, Beate Escher, Lorenz Adrian and Myriel Cooper

Journal of Hazardous Materials, 2026, 504, 141299
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Benchmarking Organic Micropollutants in Wastewater, Recycled Water and Drinking Water with In Vitro Bioassays

Beate I. Escher, Mayumi Allinson, Rolf Altenburger, Peter A. Bain, Patrick Balaguer, Wibke Busch, Jordan Crago, Nancy D. Denslow, Elke Dopp, Klara Hilscherova, Andrew R. Humpage, Anu Kumar, Marina Grimaldi, B. Sumith Jayasinghe, Barbora Jarosova, Ai Jia, Sergei Makarov, Keith A. Maruya, Alex Medvedev, Alvine C. Mehinto, Jamie E. Mendez, Anita Poulsen, Erik Prochazka, Jessica Richard, Andrea Schifferli, Daniel Schlenk, Stefan Scholz, Fujio Shiraishi, Shane Snyder, Guanyong Su, Janet Y. M. Tang, Bart van der Burg, Sander C. van der Linden, Inge Werner, Sandy D. Westerheide, Chris K. C. Wong, Min Yang, Bonnie H. Y. Yeung, Xiaowei Zhang and Frederic D. L. Leusch

Environ. Sci. Technol., 2014, 48, 1940
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In vitro bioanalytical assessment of the occurrence and variation of nine bioactivities in a drinking water treatment plant in Korea

Yegyun Choi, Yujin Lee, Sin-Yi Liou, Heejong Son and Yunho Lee

Science of The Total Environment, 2025, 971, 179070
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Assessing Performance of Wastewater Treatment Using in Vitro Cell-based Assays

Adamo Riccardo Petosa, Monica Nowierski and Viviane Yargeau

Arch Environ Contam Toxicol, 2022, 82, 21
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Spoilt for choice: A critical review on the chemical and biological assessment of current wastewater treatment technologies

Carsten Prasse, Daniel Stalter, Ulrike Schulte-Oehlmann, Jörg Oehlmann and Thomas A. Ternes

Water Research, 2015, 87, 237
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Bioanalytical assessment of adaptive stress responses in drinking water: A predictive tool to differentiate between micropollutants and disinfection by-products

Armelle Hebert, Cedric Feliers, Caroline Lecarpentier, Peta A. Neale, Rita Schlichting, Sylvie Thibert and Beate I. Escher

Water Research, 2018, 132, 340
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Adaptive Stress Response Pathways Induced by Environmental Mixtures of Bioaccumulative Chemicals in Dugongs

Ling Jin, Caroline Gaus and Beate I. Escher

Environ. Sci. Technol., 2015, 49, 6963
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Ecotoxicological impacts and macroinvertebrate responses as indicators of river restoration success

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Environ Sci Eur, 2025, 37
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Chemical and bioanalytical assessment of coal seam gas associated water

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Environmental Chemistry, 2015, 12, 267
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Applicability of Passive Sampling to Bioanalytical Screening of Bioaccumulative Chemicals in Marine Wildlife

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Environ. Sci. Technol., 2013, 47, 7982
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Toxic effects of substituted p-benzoquinones and hydroquinones in in vitro bioassays are altered by reactions with the cell assay medium

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Water Research, 2021, 202, 117415
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Removal of micropollutants and biological effects by conventional and intensified constructed wetlands treating municipal wastewater

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Water Research, 2021, 201, 117349
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Cytotoxicity Burst? Differentiating Specific from Nonspecific Effects in Tox21 in Vitro Reporter Gene Assays

Beate I. Escher, Luise Henneberger, Maria König, Rita Schlichting and Fabian C. Fischer

Environ Health Perspect, 2020, 128
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Impact of a megacity on the water quality of a tropical estuary assessed by a combination of chemical analysis and in-vitro bioassays

Romane Caracciolo, Beate I. Escher, Foon Yin Lai, Truong An Nguyen, Thi Minh Tam Le, Rita Schlichting, Rikard Tröger, Julien Némery, Karin Wiberg, Phuoc Dan Nguyen and Christine Baduel

Science of The Total Environment, 2023, 877, 162525
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Maternal paraben exposure triggers childhood overweight development

Beate Leppert, Sandra Strunz, Bettina Seiwert, Linda Schlittenbauer, Rita Schlichting, Christiane Pfeiffer, Stefan Röder, Mario Bauer, Michael Borte, Gabriele I. Stangl, Torsten Schöneberg, Angela Schulz, Isabell Karkossa, Ulrike E. Rolle-Kampczyk, Loreen Thürmann, Martin von Bergen, Beate I. Escher, Kristin M. Junge, Thorsten Reemtsma, Irina Lehmann and Tobias Polte

Nat Commun, 2020, 11
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Multilevel Screening Strategy to Identify the Hydrophobic Organic Components of Ambient PM2.5 Associated with Hepatocellular Steatosis

Zhipeng Yan, Guohua Qin, Xiaodi Shi, Xing Jiang, Zhen Cheng, Yaru Zhang, Nan Nan, Fuyuan Cao, Xinghua Qiu and Nan Sang

Environ. Sci. Technol., 2024, 58, 10458
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Effects of Leachates from UV-Weathered Microplastic in Cell-Based Bioassays

Christoph D. Rummel, Beate I. Escher, Oskar Sandblom, Merle M. Plassmann, Hans Peter H. Arp, Matthew MacLeod and Annika Jahnke

Environ. Sci. Technol., 2019, 53, 9214
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Effect-based approach for screening of chemical mixtures in whole blood of green turtles from the Great Barrier Reef

Gülsah Dogruer, Liesbeth Weijs, Janet Yat-Man Tang, Henner Hollert, Marjolijn Kock, Ian Bell, Christine A. Madden Hof and Caroline Gaus

Science of The Total Environment, 2018, 612, 321
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Reactivity of Acrylamides Causes Cytotoxicity and Activates Oxidative Stress Response

Julia Huchthausen, Beate I. Escher, Nico Grasse, Maria König, Stephan Beil and Luise Henneberger

Chem. Res. Toxicol., 2023, 36, 1374
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Testing the incorporation of bioassays into life cycle assessment: A case study on advanced wastewater treatment

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Int J Life Cycle Assess, 2025, 30, 3642
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Potentials and pitfalls of transient in vitro reporter bioassays: interference by vector geometry and cytotoxicity in recombinant zebrafish cell lines

Sebastian Lungu-Mitea and Johan Lundqvist

Arch Toxicol, 2020, 94, 2769
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Application of ARE-reporter systems in drug discovery and safety assessment

Tianqi Deng, Xiaoge Xu, Jingqi Fu, Yuanyuan Xu, Weidong Qu, Jingbo Pi and Huihui Wang

Toxicology and Applied Pharmacology, 2022, 454, 116243
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Seasonally different toxicity drivers in a river system revealed by insights from POCIS, bioassays, and suspect screening

Hyungjoon Im, Yegyun Choi, Kimberly Etombi Muambo, Yunho Lee and Jeong-Eun Oh

Water Research, 2026, 293, 125453
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Influence of Emission Sources and Tributaries on the Spatial and Temporal Patterns of Micropollutant Mixtures and Associated Effects in a Small River

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Environmental Toxicology and Chemistry, 2020, 39, 1382
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Limitations of chemical monitoring hinder aquatic risk evaluations on the macroscale

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Science, 2025, 388, 1301
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Andrographolide Derivatives Target the KEAP1/NRF2 Axis and Possess Potent Anti‐SARS‐CoV‐2 Activity

Bianca Schulte, Maria König, Beate I. Escher, Sophie Wittenburg, Matic Proj, Valentina Wolf, Carina Lemke, Gregor Schnakenburg, Izidor Sosič, Hendrik Streeck, Christa E. Müller, Michael Gütschow and Christian Steinebach

ChemMedChem, 2022, 17
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Coupling passive sampling with in vitro bioassays and chemical analysis to understand combined effects of bioaccumulative chemicals in blood of marine turtles

Ling Jin, Beate I. Escher, Colin J. Limpus and Caroline Gaus

Chemosphere, 2015, 138, 292
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Artificial infiltration in drinking water production: Addressing chemical hazards using effect-based methods

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Water Research, 2022, 221, 118776
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Baseline Toxicity Model to Identify the Specific and Nonspecific Effects of Per- and Polyfluoroalkyl Substances in Cell-Based Bioassays

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Environ. Sci. Technol., 2024, 58, 5727
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Chemical mixtures in human post-mortem tissues assessed by a combination of chemical analysis and in vitro bioassays after extraction with silicone

Andreas Baumer, Sandra Jäsch, Nadin Ulrich, Ingo Bechmann, Julia Landmann, Andreas Stöver and Beate I. Escher

Environment International, 2021, 157, 106867
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Understanding bioavailability and toxicity of sediment-associated contaminants by combining passive sampling with in vitro bioassays in an urban river catchment

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Environmental Toxicology and Chemistry, 2013, 32, 2888
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Transformation of endocrine disrupting chemicals, pharmaceutical and personal care products during drinking water disinfection

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Science of The Total Environment, 2019, 657, 1480
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Activation of the xenobiotic metabolism and oxidative stress response by mixtures of organic pollutants extracted with in-tissue passive sampling from liver, kidney, brain and blubber of marine mammals

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Environment International, 2022, 165, 107337
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Experimental Exposure Assessment of Ionizable Organic Chemicals in In Vitro Cell-Based Bioassays

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Chem. Res. Toxicol., 2020, 33, 1845
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Impact of untreated wastewater on a major European river evaluated with a combination of in vitro bioassays and chemical analysis

Maria König, Beate I. Escher, Peta A. Neale, Martin Krauss, Klára Hilscherová, Jiří Novák, Ivana Teodorović, Tobias Schulze, Sven Seidensticker, Muhammad Arslan Kamal Hashmi, Jörg Ahlheim and Werner Brack

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Organophosphate ester flame retardants have antiandrogenic potential and affect other endocrine related endpoints in vitro and in silico

Anna Kjerstine Rosenmai, Sofia Boeg Winge, Morlin Möller, Johan Lundqvist, Eva Bay Wedebye, Nikolai Georgiev Nikolov, Hanna Katarina Lilith Johansson and Anne Marie Vinggaard

Chemosphere, 2021, 263, 127703
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Systematic Review of Toxicity Removal by Advanced Wastewater Treatment Technologies via Ozonation and Activated Carbon

Johannes Völker, Michael Stapf, Ulf Miehe and Martin Wagner

Environ. Sci. Technol., 2019, 53, 7215
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Global Transcriptional Analysis of Nontransformed Human Intestinal Epithelial Cells (FHs 74 Int) after Exposure to Selected Drinking Water Disinfection By-Products

Erik Procházka, Steven D. Melvin, Beate I. Escher, Michael J. Plewa and Frederic D.L. Leusch

Environ Health Perspect, 2019, 127
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Removal of oxidative stress and genotoxic activities during drinking water production by ozonation and granular activated carbon filtration

Maria Yu, Elin Lavonen, Agneta Oskarsson and Johan Lundqvist

Environ Sci Eur, 2021, 33
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Single enrichment systems possibly underestimate both exposures and biological effects of organic pollutants from drinking water

Lan Yang, Ying Zhou, Li Chen, Hanyi Chen, Wenhao Liu, Weiwei Zheng, Melvin E. Andersen, Yubing Zhang, Yi Hu, M. James C. Crabbe and Weidong Qu

Chemosphere, 2022, 292, 133496
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Toxicity characterization of urban stormwater with bioanalytical tools

Janet Y.M. Tang, Rupak Aryal, Ana Deletic, Wolfgang Gernjak, Eva Glenn, David McCarthy and Beate I. Escher

Water Research, 2013, 47, 5594
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Bioanalytical and chemical evaluation of disinfection by-products in swimming pool water

Ruby Y.L. Yeh, Maria José Farré, Daniel Stalter, Janet Y.M. Tang, Jeffrey Molendijk and Beate I. Escher

Water Research, 2014, 59, 172
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Under pressure: assessment of chemical stress on restored river sections using effect‐based methods

Sarah Hörchner, Ariane Moulinec, Andrea Sundermann, Jörg Oehlmann and Matthias Oetken

Restoration Ecology, 2024, 32
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Following the Mixtures of Organic Micropollutants with In Vitro Bioassays in a Large Lowland River from Source to Sea

Elena Hommel, Maria König, Georg Braun, Martin Krauss, Norbert Kamjunke, Werner Brack, Anna Matousu, Tina Sanders, Ingeborg Bussmann, Eric P. Achterberg, Björn Raupers and Beate I. Escher

ACS Environ. Au, 2025, 5, 363
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The advantages of linear concentration–response curves for in vitro bioassays with environmental samples

Beate I. Escher, Peta A. Neale and Daniel L. Villeneuve

Environmental Toxicology and Chemistry, 2018, 37, 2273
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Extended anaerobic conditions in the biological wastewater treatment: Higher reduction of toxicity compared to target organic micropollutants

Johannes Völker, Tobias Vogt, Sandro Castronovo, Arne Wick, Thomas A. Ternes, Adriano Joss, Jörg Oehlmann and Martin Wagner

Water Research, 2017, 116, 220
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Effects of biostimulation by sugarcane bagasse and coffee grounds on sewage sludges, focusing agricultural use: Microbial characterization, respirometric assessment and toxicity reduction

Dânia Elisa Christofoletti Mazzeo, Andrea Misovic, Flávio Andrade Oliveira, Carlos Emílio Levy, Jörg Oehlmann and Mary Rosa Rodrigues de Marchi

Waste Management, 2020, 118, 110
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In vitro bioanalytical assessment of the occurrence and removal of bioactive chemicals in municipal wastewater treatment plants in Korea

Yegyun Choi, Eun-Young Jung, Woorim Lee, Sangki Choi, Heejong Son and Yunho Lee

Science of The Total Environment, 2023, 858, 159724
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The benefit of using in vitro bioassays to screen agricultural samples for oxidative stress: South Africa’s case

Ilzé Horak, Suranie Horn and Rialet Pieters

Journal of Environmental Science and Health, Part B, 2023, 58, 689
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Resilience of Micropollutant and Biological Effect Removal in an Aerated Horizontal Flow Treatment Wetland

Nadine A. Sossalla, Jaime Nivala, Beate I. Escher, Thorsten Reemtsma, Rita Schlichting, Manfred van Afferden and Roland A. Müller

Water, 2020, 12, 3050
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Long-Term Toxicological Monitoring of a Multibarrier Advanced Wastewater Treatment Plant Comprising Ozonation and Granular Activated Carbon with In Vitro Bioassays

Lam T. Phan, Heidemarie Schaar, Daniela Reif, Sascha Weilguni, Ernis Saracevic, Jörg Krampe, Peter A. Behnisch and Norbert Kreuzinger

Water, 2021, 13, 3245
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Sample Enrichment for Bioanalytical Assessment of Disinfected Drinking Water: Concentrating the Polar, the Volatiles, and the Unknowns

Daniel Stalter, Leon I. Peters, Elissa O’Malley, Janet Yat-Man Tang, Marion Revalor, Maria José Farré, Kalinda Watson, Urs von Gunten and Beate I. Escher

Environ. Sci. Technol., 2016, 50, 6495
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Gaining confidence in in vitro toxicity data with measured exposure concentrations

Luise Henneberger, Sophia Bardehly, Maria König and Beate I. Escher

NAM Journal, 2025, 1, 100048
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Influence of Co-Dosed Lipids from Biota Extracts on the Availability of Chemicals in In Vitro Cell-Based Bioassays

Eva B. Reiter, Annika Jahnke, Maria König, Ursula Siebert and Beate I. Escher

Environ. Sci. Technol., 2020, 54, 4240
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Temporal changes in chemical contamination of green turtles (Chelonia mydas) foraging in a heavily industrialised seaport

Kimberly A. Finlayson, Colin J. Limpus and Jason P. van de Merwe

Science of The Total Environment, 2022, 817, 152848
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Effect-based monitoring of chemical hazards in drinking water from source to tap: seasonal trends over 2 years of sampling

Johan Lundqvist, Elin Lavonen, Geeta Mandava, Erica Selin, Helene Ejhed and Agneta Oskarsson

Environ Sci Eur, 2024, 36
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Disinfection byproducts and cellular toxicity from UV/chlorine advanced oxidation for potable reuse and drinking water treatment compared to chlorination and UV/hydrogen peroxide

Nathan Moore, Liz Taylor-Edmonds, Nicole Zollbrecht, Kirsten Yeung, Jianxian Sun, Kevin Legaspi-Annett, Katie Vanyo, Gabriela Barreto Bossoni, Tianyi Chen, Vishal Manek, Erin Mackey, Hui Peng, Susan Andrews and Ron Hofmann

Science of The Total Environment, 2026, 1011, 181151
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Does co-extracted dissolved organic carbon cause artefacts in cell-based bioassays?

Peta A. Neale and Beate I. Escher

Chemosphere, 2014, 108, 281
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Development of a bioanalytical test battery for water quality monitoring: Fingerprinting identified micropollutants and their contribution to effects in surface water

Peta A. Neale, Rolf Altenburger, Selim Aït-Aïssa, François Brion, Wibke Busch, Gisela de Aragão Umbuzeiro, Michael S. Denison, David Du Pasquier, Klára Hilscherová, Henner Hollert, Daniel A. Morales, Jiří Novák, Rita Schlichting, Thomas-Benjamin Seiler, Helene Serra, Ying Shao, Andrew J. Tindall, Knut Erik Tollefsen, Timothy D. Williams and Beate I. Escher

Water Research, 2017, 123, 734
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