Nickel-catalyzed cyanation of aryl halides and triflates using acetonitrile via C–CN bond cleavage assisted by 1,4-bis(trimethylsilyl)-2,3,5,6-tetramethyl-1,4-dihydropyrazine

Yohei Ueda, Nagataka Tsujimoto, Taiga Yurino, Hayato Tsurugi and Kazushi Mashima

Chem. Sci., 2019, 10, 994
DOI: 10.1039/C8SC04437F

Cu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions

Asit Kumar Das, Sneha Nandy and Sanjay Bhar

RSC Adv., 2022, 12, 4605
DOI: 10.1039/D1RA07701E

Copper-catalyzed oxidative direct C3-cyanoarylation of quinoxalin-2(1H)-onesviadenitrogenative ring-opening of 3-aminoindazoles

Chen-Xu Mou, Jin-Wei Yuan, Qian Hu, Bing-Jie Han, Liang-Ru Yang, Yong-Mei Xiao, Lu-Lu Fan, Shou-Ren Zhang and Ling-Bo Qu

New J. Chem., 2023, 47, 3783
DOI: 10.1039/D2NJ04309B

A highly efficient, ligand-free and recyclable SBA-15 supported Cu2O catalyzed cyanation of aryl iodides with potassium hexacyanoferrate(ii)

Wenzhu Yin, Rui Liu, Guangke He, Wangjie Lv and Hongjun Zhu

RSC Adv., 2014, 4, 37773
DOI: 10.1039/C4RA05203J

Cu-catalyzed C–N bond cleavage of 3-aminoindazoles for the C–H arylation of enamines

Yao Zhou, Ya Wang, Zhiyi Song, Tamaki Nakano and Qiuling Song

Org. Chem. Front., 2020, 7, 25
DOI: 10.1039/C9QO01177C

Plasma-assisted methane conversion to HCN: the prospect and challenges

Na Ning, Chao Qian and Shaodong Zhou

Catal. Sci. Technol., 2025, 15, 249
DOI: 10.1039/D4CY01239A

Optimization of triazole-based TGR5 agonists towards orally available agents

Kentaro Futatsugi, Kevin B. Bahnck, Martin B. Brenner, Joanne Buxton, Janice E. Chin, Steven B. Coffey, Jeffrey Dubins, Declan Flynn, Denise Gautreau, Angel Guzman-Perez, John R. Hadcock, David Hepworth, Michael Herr, Terri Hinchey, Ann M. Janssen, Sandra M. Jennings, Wenhua Jiao, Sophie Y. Lavergne, Bryan Li, Mei Li, Michael J. Munchhof, Suvi T. M. Orr, David W. Piotrowski, Nicole S. Roush, Matthew Sammons, Benjamin D. Stevens, Gregory Storer, Jian Wang, Joseph S. Warmus, Liuqing Wei and Angela C. Wolford

Med. Chem. Commun., 2013, 4, 205
DOI: 10.1039/C2MD20174G

Dehydration of primary amides to nitriles in water. Late-stage functionalization and 1-pot multistep chemoenzymatic processes under micellar catalysis conditions

Alex B. Wood, Joseph R. A. Kincaid and Bruce H. Lipshutz

Green Chem., 2022, 24, 2853
DOI: 10.1039/D1GC04671C

SAR mining and its application to the design of TRPA1 antagonists

James E. J. Mills, Alan D. Brown, Thomas Ryckmans, Duncan C. Miller, Sarah E. Skerratt, Carolyn M. Barker and Mark E. Bunnage

Med. Chem. Commun., 2012, 3, 174
DOI: 10.1039/C1MD00213A

Deconjugative alkylation/Heck reaction as a simple platform for dihydronaphthalene synthesis

Primali V. Navaratne and Alexander J. Grenning

Org. Biomol. Chem., 2017, 15, 69
DOI: 10.1039/C6OB02250B

Gold-catalyzed azidation, cyanation, and alkynylation of aryl iodides from readily available TMS-N3, TMS-CN, and alkynyl-TMS

Hongyan Liu and Bo Xu

Chem. Commun., 2025
DOI: 10.1039/D5CC02290H

Synthesis and evaluation of the antitumor activity of polyhalo acridone derivatives

Chao Huang, Sheng-Jiao Yan, Xiang-Hui Zeng, Bo Sun, Min-Bo Lan and Jun Lin

RSC Adv., 2015, 5, 17444
DOI: 10.1039/C4RA12354A

A convenient reagent for the conversion of aldoximes into nitriles and isonitriles

Wei Zhang, Jin-Hong Lin, Pengfei Zhang and Ji-Chang Xiao

Chem. Commun., 2020, 56, 6221
DOI: 10.1039/D0CC00188K

Nickel-catalyzed cyanation reaction of aryl/alkenyl halides with alkyl isocyanides

Yanling Zhang, Zhiguo Zhang, Yuanyuan Hu, Yunkui Liu, Hongwei Jin and Bingwei Zhou

Org. Biomol. Chem., 2022, 20, 8049
DOI: 10.1039/D2OB01240E

“One-pot” synthesis of amidoxime via Pd-catalyzed cyanation and amidoximation

Chu-Ting Yang, Jun Han, Jun Liu, Mei Gu, Yi Li, Jun Wen, Hai-Zhu Yu, Sheng Hu and Xiaolin Wang

Org. Biomol. Chem., 2015, 13, 2541
DOI: 10.1039/C4OB02456G

A General, Practical Palladium‐Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides

Todd D. Senecal, Wei Shu and Stephen L. Buchwald

Angewandte Chemie, 2013, 125, 10219
DOI: 10.1002/ange.201304188

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2011 – 2014)

Xiao Li, Lingzi Zhang, Ye Tian, Yu’ning Song, Peng Zhan and Xinyong Liu

Expert Opinion on Therapeutic Patents, 2014, 24, 1199
DOI: 10.1517/13543776.2014.964685

Nickel-Catalyzed Cyanation of Aryl Halides

Zhenqiang Ma, Cuimeng Huo, Duo Zhou, Jingyi Zhang, Hongjun Kong, Wenke Ren, Fengbo Qu, Tingting Liu, Hui Chen and Xilong Wang

Molecules, 2025, 30, 3440
DOI: 10.3390/molecules30163440

Graphene oxide as an active carbocatalyst for cyanation of quinoline and isoquinoline N-Oxides

Panpan Huang, Xiangjun Peng, Genhong Qiu, Keyang Yu, Hong Li, Lingting Kong, Jiaming Hu, Zhengwang Chen, Qing Huang and Liangxian Liu

Tetrahedron, 2021, 83, 131964
DOI: 10.1016/j.tet.2021.131964

Synthesis of Multisubstituted Arylnitriles via Tf2O-Mediated Benzannulation of Enaminones with Acylacetonitriles

Xiaohan Zhang, Fei Li, Yue Zhou, Junxian Zhang, Benwei Zhou, Lulu Chen, Jianping Lin and Changyuan Zhang

Org. Lett., 2025, 27, 2400
DOI: 10.1021/acs.orglett.5c00261

Comparison of the Non‐Nucleoside Reverse Transcriptase Inhibitor Lersivirine with its Pyrazole and Imidazole Isomers

Lyn H. Jones, Gill Allan, Romuald Corbau, Donald S. Middleton, Charles E. Mowbray, Sandra D. Newman, Chris Phillips, Rob Webster and Mike Westby

Chem Biol Drug Des, 2011, 77, 393
DOI: 10.1111/j.1747-0285.2011.01113.x

Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors

Anthony V. Pensa, Maris A. Cinelli, Huiying Li, Georges Chreifi, Paramita Mukherjee, Linda J. Roman, Pavel Martásek, Thomas L. Poulos and Richard B. Silverman

J. Med. Chem., 2017, 60, 7146
DOI: 10.1021/acs.jmedchem.7b00835

Topographical Mapping of Isoform-Selectivity Determinants for J-Channel-Binding Inhibitors of Sphingosine Kinases 1 and 2

David R. Adams, Salha Tawati, Giacomo Berretta, Paula Lopez Rivas, Jessica Baiget, Zhong Jiang, Aisha Alsfouk, Simon P. Mackay, Nigel J. Pyne and Susan Pyne

J. Med. Chem., 2019, 62, 3658
DOI: 10.1021/acs.jmedchem.9b00162

4-Cyanophenols bearing metabolically robust substituents

Patrick S. Johnson, Toby J. Underwood and Simon Wheeler

Tetrahedron Letters, 2011, 52, 3226
DOI: 10.1016/j.tetlet.2011.04.052

ChemInform Abstract: Aromatic Chloride to Nitrile Transformation: Medicinal and Synthetic Chemistry

Lyn H. Jones, Nicholas W. Summerhill, Nigel A. Swain and James E. Mills

ChemInform, 2011, 42
DOI: 10.1002/chin.201120242

Assembly of Terpenoid Cores by a Simple, Tunable Strategy

Ouidad Lahtigui, Fabien Emmetiere, Wei Zhang, Liban Jirmo, Samira Toledo‐Roy, John C. Hershberger, Jocelyn M. Macho and Alexander J. Grenning

Angew Chem Int Ed, 2016, 55, 15792
DOI: 10.1002/anie.201608863

Assembly of Terpenoid Cores by a Simple, Tunable Strategy

Ouidad Lahtigui, Fabien Emmetiere, Wei Zhang, Liban Jirmo, Samira Toledo‐Roy, John C. Hershberger, Jocelyn M. Macho and Alexander J. Grenning

Angewandte Chemie, 2016, 128, 16024
DOI: 10.1002/ange.201608863

New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms

Sophie S. Spurr, Elliott D. Bayle, Wenyu Yu, Fengling Li, Wolfram Tempel, Masoud Vedadi, Matthieu Schapira and Paul V. Fish

Bioorganic & Medicinal Chemistry Letters, 2016, 26, 4518
DOI: 10.1016/j.bmcl.2016.07.041

Oxidative transformation of azides to aryl nitriles using DIB/TBHP: scope and mechanistic insights

Yi Zhao, Xinying Chew, Gulice Y.C. Leung and Ying-Yeung Yeung

Tetrahedron Letters, 2012, 53, 4766
DOI: 10.1016/j.tetlet.2012.06.131

Electrochemically Driven Denitrative Cyanation of Nitroarenes

Yiyi Chen, Qisheng Chen, Shuangquan Zhang, Kun Feng, Yuan-Qing Xu, Xiaohui Chen, Zhong-Yan Cao and Xianqiang Kong

Org. Lett., 2024, 26, 7555
DOI: 10.1021/acs.orglett.4c02552

Discovery of novel PTHR1 antagonists: Design, synthesis, and structure activity relationships

Yoshikazu Arai, Yohei Kiyotsuka, Kousei Shimada, Kazunori Oyama and Masanori Izumi

Bioorganic & Medicinal Chemistry Letters, 2019, 29, 2613
DOI: 10.1016/j.bmcl.2019.07.052

Lewis acid catalyzed nitrile synthesis from aldehyde

Dipakkumar Bariya and Satyendra Mishra

Tetrahedron Letters, 2022, 94, 153711
DOI: 10.1016/j.tetlet.2022.153711

1-Oxo-1H-phenalene-2,3-dicarbonitrile Heteroaromatic Scaffold: Revised Structure and Mechanistic Studies

Romaric Lenk, Arnaud Tessier, Pierre Lefranc, Virginie Silvestre, Aurélien Planchat, Virginie Blot, Didier Dubreuil and Jacques Lebreton

J. Org. Chem., 2014, 79, 9754
DOI: 10.1021/jo5016932

Nickel-Catalyzed Cyanation of Unactivated Alkyl Chlorides or Bromides with Zn(CN)2

Aiyou Xia, Xin Xie, Haoyi Chen, Jidong Zhao, Chunli Zhang and Yuanhong Liu

Org. Lett., 2018, 20, 7735
DOI: 10.1021/acs.orglett.8b03539

Nickel‐Catalyzed Cyanation of Aryl Chlorides and Triflates Using Butyronitrile: Merging Retro‐hydrocyanation with Cross‐Coupling

Peng Yu and Bill Morandi

Angew Chem Int Ed, 2017, 56, 15693
DOI: 10.1002/anie.201707517

A Novel Ketonitrile Synthesis by Palladium‐Catalyzed Carbonylative Coupling Reactions of Amides with Arylboronic Acids

Wen‐Peng Mai, Yang Liu, Hong‐Dai Sui, Yong‐Mei Xiao, Pu Mao and Kui Lu

Eur J Org Chem, 2019, 2019, 7814
DOI: 10.1002/ejoc.201901396

Development of Inhibitors of SAICAR Synthetase (PurC) from Mycobacterium abscessus Using a Fragment-Based Approach

Sitthivut Charoensutthivarakul, Sherine E. Thomas, Amy Curran, Karen P. Brown, Juan M. Belardinelli, Andrew J. Whitehouse, Marta Acebrón-García-de-Eulate, Jaspar Sangan, Subramanian G. Gramani, Mary Jackson, Vitor Mendes, R. Andres Floto, Tom L. Blundell, Anthony G. Coyne and Chris Abell

ACS Infect. Dis., 2022, 8, 296
DOI: 10.1021/acsinfecdis.1c00432

Water-Dispersible Pd–N-Heterocyclic Carbene Complex Immobilized on Magnetic Nanoparticles as a New Heterogeneous Catalyst for Fluoride-Free Hiyama, Suzuki–Miyaura and Cyanation Reactions in Aqueous Media

Farhad Omarzehi Chahkamali, Sara Sobhani and José Miguel Sansano

Catal Lett, 2022, 152, 2650
DOI: 10.1007/s10562-021-03824-0

Novel Indirect AMP-Activated Protein Kinase Activators: Identification of a Second-Generation Clinical Candidate with Improved Physicochemical Properties and Reduced hERG Inhibitory Activity

Kazuyuki Kuramoto, Yuki Sawada, Tomohiro Yamada, Takeyuki Nagashima, Kei Ohnuki and Takashi Shin

Chem. Pharm. Bull., 2020, 68, 452
DOI: 10.1248/cpb.c20-00015

Alkyne-Tag Raman Imaging for Visualization of Mobile Small Molecules in Live Cells

Hiroyuki Yamakoshi, Kosuke Dodo, Almar Palonpon, Jun Ando, Katsumasa Fujita, Satoshi Kawata and Mikiko Sodeoka

J. Am. Chem. Soc., 2012, 134, 20681
DOI: 10.1021/ja308529n

A Greener, Versatile and Convenient Approach for Catalyst Free Conversion of Pyrazole Aldehydes into Carbonitriles

Selvaraj Jayanthi, Manickam Pramesh, Periyasamy Monisha, Moorthy Vetriselvan and Ragunathan Venkatachalam

Asian J. Chem., 2022, 34, 2887
DOI: 10.14233/ajchem.2022.23957

Catalyst-free, efficient and one pot protocol for synthesis of nitriles from aldehydes using glycerol as green solvent

Ajit P. Ingale, Shripad M. Patil and Sandeep V. Shinde

Tetrahedron Letters, 2017, 58, 4845
DOI: 10.1016/j.tetlet.2017.11.032

Rh(III)-catalyzed direct cross-dehydrogenative coupling of aromatic nitriles with heteroarenes: Rapid access to biheteroaryl-2-carbonitriles

Huibei Xu, Yanying Zhu, Xinyue Chai, Jiahui Yang and Lin Dong

Green Synthesis and Catalysis, 2020, 1, 167
DOI: 10.1016/j.gresc.2020.09.001

Oxidative Radical Transnitrilation of Arylboronic Acids with Trityl Isocyanide

Zhiyuan Xu, Xiaojuan Liang and Huan Li

Org. Lett., 2022, 24, 9403
DOI: 10.1021/acs.orglett.2c03778

Synthesis and antimicrobial activity of polyhalo isophthalonitrile derivatives

Chao Huang, Sheng-Jiao Yan, Neng-Qin He, Ya-Juan Tang, Xing-Hong Wang and Jun Lin

Bioorganic & Medicinal Chemistry Letters, 2013, 23, 2399
DOI: 10.1016/j.bmcl.2013.02.033

Rational Catalysis Design on the Basis of Mechanistic Understanding: Highly Efficient Pd-Catalyzed Cyanation of Aryl Bromides with NaCN in Recyclable Solvents

Alexander V. Ushkov and Vladimir V. Grushin

J. Am. Chem. Soc., 2011, 133, 10999
DOI: 10.1021/ja2042035

Palladium‐Catalyzed Cyanation of Aryl Halides Using Formamide and Cyanuric Chloride as a New “CN” Source

Esmaeil Niknam, Farhad Panahi and Ali Khalafi‐Nezhad

Eur J Org Chem, 2020, 2020, 2699
DOI: 10.1002/ejoc.202000117

Natural Breviscapin, Mangiferin, and a Modified Mangostin Present Inhibitory Effect on Dipeptidyl Peptidase‐IV

Bo Hou, Meng‐Ting Kuang, Xiao‐Qian Chi, Jin‐Yu Li, Liu Yang, Zhen‐Hua Liu, Ming‐Yan Yuan, Qing‐Hua Kong, Jiang‐Miao Hu and Jun Zhou

ChemistrySelect, 2018, 3, 10864
DOI: 10.1002/slct.201801350

Optimization of Sphingosine-1-phosphate-1 Receptor Agonists: Effects of Acidic, Basic, and Zwitterionic Chemotypes on Pharmacokinetic and Pharmacodynamic Profiles

John Skidmore, Jag Heer, Christopher N. Johnson, David Norton, Sally Redshaw, Jennifer Sweeting, David Hurst, Andrew Cridland, David Vesey, Ian Wall, Mahmood Ahmed, Dean Rivers, James Myatt, Gerard Giblin, Karen Philpott, Umesh Kumar, Alexander Stevens, Rino A. Bit, Andrea Haynes, Simon Taylor, Robert Watson, Jason Witherington, Emmanuel Demont and Tom D. Heightman

J. Med. Chem., 2014, 57, 10424
DOI: 10.1021/jm5010336

Development and Molecular Understanding of a Pd‐Catalyzed Cyanation of Aryl Boronic Acids Enabled by High‐Throughput Experimentation and Data Analysis

Jordan De Jesus Silva, Niccolò Bartalucci, Benson Jelier, Samantha Grosslight, Tobias Gensch, Claas Schünemann, Bernd Müller, Paul C. J. Kamer, Christophe Copéret, Matthew S. Sigman and Antonio Togni

Helvetica Chimica Acta, 2021, 104
DOI: 10.1002/hlca.202100200

Pd‐Catalyzed Cyanation of (Hetero)Aryl Halides by Using Biphosphine Ligands

Shaoke Zhang, Helfried Neumann and Matthias Beller

Chemistry A European J, 2018, 24, 67
DOI: 10.1002/chem.201704178

Nickel-Catalyzed Reductive Cyanation of Aryl Halides and Epoxides with Cyanogen Bromide

Yu-Juan Wu, Chen Ma, Muhammad Bilal and Yu-Feng Liang

Molecules, 2024, 29, 6016
DOI: 10.3390/molecules29246016

A Robust Nickel‐Interlocked π‐Conjugated Covalent Organic Framework Catalyst for Photocatalytic Aromatic Finkelstein and Retro‐Finkelstein Reactions

Ayan Jati, Suranjana Dam, Tuhin Suvra Khan and Biplab Maji

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202510788

Palladium-Catalyzed Late-Stage Direct Arene Cyanation

Da Zhao, Peng Xu and Tobias Ritter

Chem, 2019, 5, 97
DOI: 10.1016/j.chempr.2018.09.027

Synthesis and characterization of novel combretastatin analogues of 1,1-diaryl vinyl sulfones, with antiproliferative potential via in-silico and in-vitro studies

Godshelp O. Egharevba, Ahmed Kamal, Omotayo O. Dosumu, Sunitha Routhu, Olatomide A. Fadare, Stephen O. Oguntoye, Stanislaus N. Njinga and Abimbola P. Oluyori

Sci Rep, 2022, 12
DOI: 10.1038/s41598-022-05958-6

Design of Potent mRNA Decapping Scavenger Enzyme (DcpS) Inhibitors with Improved Physicochemical Properties To Investigate the Mechanism of Therapeutic Benefit in Spinal Muscular Atrophy (SMA)

Ariamala Gopalsamy, Arjun Narayanan, Shenping Liu, Mihir D. Parikh, Robert E. Kyne, Olugbeminiyi Fadeyi, Michael A. Tones, Jonathan J. Cherry, Joseph F. Nabhan, Gregory LaRosa, Donna N. Petersen, Carol Menard, Timothy L. Foley, Stephen Noell, Yong Ren, Paula M. Loria, Jodi Maglich-Goodwin, Haojing Rong and Lyn H. Jones

J. Med. Chem., 2017, 60, 3094
DOI: 10.1021/acs.jmedchem.7b00124

Photoinduced Nickel-Catalyzed Demethylative Cyanation and Decarboxylative Cyanomethylation of Aryl Halides

Shao-Chi Lee, Chen Zhu, Kun Huang, Jeremy A. Bau, Jiaqi Jia, Huifeng Yue and Magnus Rueping

ACS Catal., 2023, 13, 16279
DOI: 10.1021/acscatal.3c04745

Recyclable and Reusable Pd(OAc)2/XPhos–SO3Na/PEG-400/H2O System for Cyanation of Aryl Chlorides with Potassium Ferrocyanide

Mingzhong Cai, Rong Liu, Caifeng Xu and Bin Huang

Catal Lett, 2022, 152, 2688
DOI: 10.1007/s10562-021-03864-6

Pharmacophore Establishment and Optimization of Saturated 1,6-Naphthyridine-Fused Quinazolinones that Inhibit Meningoencephalitis-Causing Naegleria fowleri

Matthew S. Lish, Jillian E. M. McKeon, Caroline M. Palmentiero, Julia M. Pomeroy, Colm P. Roster, Ilia A. Guzei, James C. Morris and Jennifer E. Golden

J. Med. Chem., 2024, 67, 18265
DOI: 10.1021/acs.jmedchem.4c01630

Nickel-Catalyzed Cyanation of Phenol Derivatives with Zn(CN)2 Involving C–O Bond Cleavage

Yi Gan, Gaonan Wang, Xin Xie and Yuanhong Liu

J. Org. Chem., 2018, 83, 14036
DOI: 10.1021/acs.joc.8b02498

Direct Carbon Isotope Exchange of Pharmaceuticals via Reversible Decyanation

Minghao Feng, Joao De Oliveira, Antoine Sallustrau, Gianluca Destro, Pierre Thuéry, Sebastien Roy, Thibault Cantat, Charles S. Elmore, Jorg Blankenstein, Frédéric Taran and Davide Audisio

J. Am. Chem. Soc., 2021, 143, 5659
DOI: 10.1021/jacs.1c01923

Nickel-catalyzed cyanation of C—S bond using CO2 and NH3

Qin Shi, Yang Li, Yudong Li, Yanan Dong, Shaoli Liu, Zhen Li, Lin He, Liwei Sun and Yuehui Li

Journal of Catalysis, 2025, 442, 115870
DOI: 10.1016/j.jcat.2024.115870

Palladium catalyzed cyanation of o-dichloroarenes with potassium hexacyanoferrate(ii)

E. A. Savicheva and V. P. Boyarskiy

Russ Chem Bull, 2012, 61, 980
DOI: 10.1007/s11172-012-0141-3

Pd@CeO2‐catalyzed cyanation of aryl iodides with K4Fe(CN)6·3H2O under visible light irradiation

Shengyu Wang, Jianqiang Wang, Junyi Pan, Cheng Liu, Xubin Gong and Cheng Guo

Applied Organom Chemis, 2021, 35
DOI: 10.1002/aoc.6135

A Robust Nickel‐Interlocked π‐Conjugated Covalent Organic Framework Catalyst for Photocatalytic Aromatic Finkelstein and Retro‐Finkelstein Reactions

Ayan Jati, Suranjana Dam, Tuhin Suvra Khan and Biplab Maji

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202510788

Late‐Stage C−H Activation of Drug (Derivative) Molecules with Pd(ll) Catalysis

Su Yong Shim

Chemistry A European J, 2023, 29
DOI: 10.1002/chem.202302620

General and Mild Nickel-Catalyzed Cyanation of Aryl/Heteroaryl Chlorides with Zn(CN)2: Key Roles of DMAP

Xingjie Zhang, Aiyou Xia, Haoyi Chen and Yuanhong Liu

Org. Lett., 2017, 19, 2118
DOI: 10.1021/acs.orglett.7b00732

Synthesis, biological evaluation, and molecular modeling of nitrile‐containing compounds: Exploring multiple activities as anti‐Alzheimer agents

Daniel Silva, Eduarda Mendes, Eleanor J. Summers, Ana Neca, Ana C. Jacinto, Telma Reis, Paula Agostinho, Irene Bolea, M. Luisa Jimeno, M. Luisa Mateus, Ana M. F. Oliveira‐Campos, Mercedes Unzeta, José Marco‐Contelles, Magdalena Majekova, Rona R. Ramsay and M. Carmo Carreiras

Drug Development Research, 2020, 81, 215
DOI: 10.1002/ddr.21594

Nickel‐Catalyzed Cyanation of Aryl Chlorides and Triflates Using Butyronitrile: Merging Retro‐hydrocyanation with Cross‐Coupling

Peng Yu and Bill Morandi

Angewandte Chemie, 2017, 129, 15899
DOI: 10.1002/ange.201707517

Copper-Mediated C–X Functionalization of Aryl Halides

P. J. Amal Joseph and S. Priyadarshini

Org. Process Res. Dev., 2017, 21, 1889
DOI: 10.1021/acs.oprd.7b00285

Cu-Catalyzed Aromatic Metamorphosis of 3-Aminoindazoles

Yao Zhou, Lu Lin, Ya Wang, Jun Zhu and Qiuling Song

Org. Lett., 2019, 21, 7630
DOI: 10.1021/acs.orglett.9b02933

C-Alkylation of Various Carbonucleophiles with Secondary Alcohols under CoIII-Catalysis

Priyanka Chakraborty, Nidhi Garg, Eric Manoury, Rinaldo Poli and Basker Sundararaju

ACS Catal., 2020, 10, 8023
DOI: 10.1021/acscatal.0c01728

Copper‐Catalyzed Cyanation of Aryl Iodides with Formamide as the Cyano Source

Sha Peng and Luo Yang

Asian J Org Chem, 2022, 11
DOI: 10.1002/ajoc.202200437

Discovery of a potent orally bioavailable retinoic acid receptor-related orphan receptor-gamma-t (RORγt) inhibitor, S18-000003

Yoshikazu Sasaki, Masahide Odan, Shiho Yamamoto, Shiro Kida, Azumi Ueyama, Masaya Shimizu, Takayo Haruna, Ayahisa Watanabe and Takayuki Okuno

Bioorganic & Medicinal Chemistry Letters, 2018, 28, 3549
DOI: 10.1016/j.bmcl.2018.09.032

The application and development of cyanating reagents in asymmetric cyanation reactions

Ruirui Hua, Chukai Shao and Fu-Xue Chen

Tetrahedron Letters, 2025, 160, 155549
DOI: 10.1016/j.tetlet.2025.155549

A General, Practical Palladium‐Catalyzed Cyanation of (Hetero)Aryl Chlorides and Bromides

Todd D. Senecal, Wei Shu and Stephen L. Buchwald

Angew Chem Int Ed, 2013, 52, 10035
DOI: 10.1002/anie.201304188

Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors

Benjamin N. Atkinson, David Steadman, William Mahy, Yuguang Zhao, James Sipthorp, Elliott D. Bayle, Fredrik Svensson, George Papageorgiou, Fiona Jeganathan, Sarah Frew, Amy Monaghan, Magda Bictash, E. Yvonne Jones and Paul V. Fish

Bioorganic & Medicinal Chemistry Letters, 2020, 30, 126751
DOI: 10.1016/j.bmcl.2019.126751

A Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora A

Mathew P. Martin, Jin-Yi Zhu, Harshani R. Lawrence, Roberta Pireddu, Yunting Luo, Riazul Alam, Sevil Ozcan, Said M. Sebti, Nicholas J. Lawrence and Ernst Schönbrunn

ACS Chem. Biol., 2012, 7, 698
DOI: 10.1021/cb200508b