One-pot and large-scale production of uniform ytterbium-doped perovskite nanocrystals with controllable optical properties

Jing Chu, Linxuan Zhang, Quanjie Lv, Yijun Han, Kang Sun and Ke Tao

J. Mater. Chem. C, 2024, 12, 17647
DOI: 10.1039/D4TC03364G

The two-step mechanism of nucleation of crystals in solution

Peter G. Vekilov

Nanoscale, 2010, 2, 2346
DOI: 10.1039/c0nr00628a

Self-association of organic solutes in solution: a NEXAFS study of aqueous imidazole

M. J. Thomason, C. R. Seabourne, B. M. Sattelle, G. A. Hembury, J. S. Stevens, A. J. Scott, E. F. Aziz and S. L. M. Schroeder

Faraday Discuss., 2015, 179, 269
DOI: 10.1039/C5FD00005J

Multiple pathways in NaCl homogeneous crystal nucleation

Aaron R. Finney and Matteo Salvalaglio

Faraday Discuss., 2022, 235, 56
DOI: 10.1039/D1FD00089F

Crystallization of molecular systems from solution: phase diagrams, supersaturation and other basic concepts

Gérard Coquerel

Chem. Soc. Rev., 2014, 43, 2286
DOI: 10.1039/C3CS60359H

X-ray Raman scattering: a newin situprobe of molecular structure during nucleation and crystallization from liquid solutions

Laila H. Al-Madhagi, Sin-Yuen Chang, Mahalingam Balasubramanian, Anna B. Kroner, Elizabeth J. Shotton, Elizabeth A. Willneff, Bhoopesh Mishra and Sven L. M. Schroeder

CrystEngComm, 2018, 20, 6871
DOI: 10.1039/C8CE00929E

Using optical tweezing to control phase separation and nucleation near a liquid–liquid critical point

Finlay Walton and Klaas Wynne

Soft Matter, 2019, 15, 8279
DOI: 10.1039/C9SM01297D

Mesoscale clusters of organic solutes in solution and their role in crystal nucleation

Michael Svärd

CrystEngComm, 2022, 24, 5182
DOI: 10.1039/D2CE00718E

Molecular evolution pathways during nucleation of small organic molecules: solute-rich pre-nucleation species enable control over the nucleation process

Shuyi Zong, Jingkang Wang, Xin Huang, Ting Wang, Qi Liu, Beiqian Tian, Chuang Xie and Hongxun Hao

Phys. Chem. Chem. Phys., 2020, 22, 18663
DOI: 10.1039/D0CP03493B

Crystal templating through liquid–liquid phase separation

Joanna Mosses, David A. Turton, Leo Lue, Jan Sefcik and Klaas Wynne

Chem. Commun., 2015, 51, 1139
DOI: 10.1039/C4CC07880B

Liquid–liquid phase separation and crystallization of aspirin polymorphs from a water–acetonitrile mixed solvent medium through a swift cooling process

Ramya Muthusamy and Srinivasan Karuppannan

CrystEngComm, 2023, 25, 6611
DOI: 10.1039/D3CE00611E

Complex oiling-out behavior of procaine with stable and metastable liquid phases

Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom and Na Li

Phys. Chem. Chem. Phys., 2024, 26, 808
DOI: 10.1039/D3CP04622B

The role of cluster formation and metastable liquid—liquid phase separation in protein crystallization

Fajun Zhang, Felix Roosen-Runge, Andrea Sauter, Roland Roth, Maximilian W. A. Skoda, Robert M. J. Jacobs, Michael Sztucki and Frank Schreiber

Faraday Discuss., 2012, 159, 313
DOI: 10.1039/c2fd20021j

Understanding the nanoscale phenomena of nucleation and crystal growth in electrodeposition

Jiancheng Lin, Mohamed Kilani, Mahroo Baharfar, Ren Wang and Guangzhao Mao

Nanoscale, 2024, 16, 19564
DOI: 10.1039/D4NR02389G

Universal two-step crystallization of DNA-functionalized nanoparticles

Wei Dai, Sanat K. Kumar and Francis W. Starr

Soft Matter, 2010, 6, 6130
DOI: 10.1039/c0sm00484g

Effect of mixing, concentration and temperature on the formation of mesostructured solutions and their role in the nucleation of dl-valine crystals

Anna Jawor-Baczynska, Barry D. Moore and Jan Sefcik

Faraday Discuss., 2015, 179, 141
DOI: 10.1039/C4FD00262H

Population and size distribution of solute-rich mesospecies within mesostructured aqueous amino acid solutions

Anna Jawor-Baczynska, Barry D. Moore, Han Seung Lee, Alon V. McCormick and Jan Sefcik

Faraday Discuss., 2013, 167, 425
DOI: 10.1039/c3fd00066d

Control of the nucleation of sickle cell hemoglobin polymers by free hematin

Veselina Uzunova, Weichun Pan, Vassiliy Lubchenko and Peter G. Vekilov

Faraday Discuss., 2012, 159, 87
DOI: 10.1039/c2fd20058a

Investigation of the effect of liquid–liquid phase separation (LLPS) on nucleation and different growth stages of vanillin and bulk growth of defect-free single crystals from aqueous solution – a new approach

P. Parimaladevi, C. Kavitha and K. Srinivasan

CrystEngComm, 2014, 16, 2565
DOI: 10.1039/C3CE42416B

Crystallization in Confinement

Fiona C. Meldrum and Cedrick O'Shaughnessy

Advanced Materials, 2020, 32
DOI: 10.1002/adma.202001068

Polymorph-Controlled Crystallization of Acetaminophen through Femtosecond Laser Irradiation

Shubo Wang, Sumei Wang, Lan Jiang, Mengmeng Wang, Yuyin Wei, Jiaxin Sun, Shenghua Zhan, Xin Li and Liangti Qu

Crystal Growth & Design, 2019, 19, 3265
DOI: 10.1021/acs.cgd.9b00123

Formation, Dissolution, and Transfer Dynamics of a Millimeter-Scale Thin Liquid Droplet in Glycine Solution by Laser Trapping

Ken-ichi Yuyama, Thitiporn Rungsimanon, Teruki Sugiyama and Hiroshi Masuhara

J. Phys. Chem. C, 2012, 116, 6809
DOI: 10.1021/jp210576k

Chemistry and ionization of HPMCAS influences the dissolution and solution-mediated crystallization of posaconazole amorphous solid dispersions

Dishan D. Shah and Lynne S. Taylor

Journal of Pharmaceutical Sciences, 2025, 114, 223
DOI: 10.1016/j.xphs.2024.08.023

Physical chemistry of supersaturated solutions and implications for oral absorption

Lynne S. Taylor and Geoff G.Z. Zhang

Advanced Drug Delivery Reviews, 2016, 101, 122
DOI: 10.1016/j.addr.2016.03.006

Ultrasonic Irradiation and Seeding To Prevent Metastable Liquid–Liquid Phase Separation and Intensify Crystallization

Zhenguo Gao, Fatima Altimimi, Junbo Gong, Ying Bao, Jingkang Wang and Sohrab Rohani

Crystal Growth & Design, 2018, 18, 2628
DOI: 10.1021/acs.cgd.8b00284

FM-AFM with a Hanging Fiber Probe for the Study of Liquid–Liquid Interfaces

Matthieu Rocheron, Christian Curtil and Hubert R. Klein

Langmuir, 2022, 38, 6592
DOI: 10.1021/acs.langmuir.2c00450

Impact of Solvent Selection and Temperature on Oiling-Out Propensity During Crystallization of a Pharmaceutical Drug Candidate BI 730357

Da Hye Yang, Francesco Ricci, Fredrik L. Nordstrom and Na Li

Crystal Growth & Design, 2025, 25, 13
DOI: 10.1021/acs.cgd.4c01024

Numerical simulation of particle formation processes via a population balance model incorporating nucleation pathway variation

Yuya Iida and Satoshi Watanabe

Results in Engineering, 2025, 26, 105128
DOI: 10.1016/j.rineng.2025.105128

Oiling out or molten hydrate—liquid–liquid phase separation in the system vanillin–water

Michael Svärd, Sandra Gracin and Åke C. Rasmuson

Journal of Pharmaceutical Sciences, 2007, 96, 2390
DOI: 10.1002/jps.20899

Bottom‐up Growth of Convex Sphere with Adjustable Cu(0)/Cu(I) Interfaces for Effective C2 Production from CO2 Electroreduction

Huan Liu, Chenghan Yang, Tong Bian, Huijun Yu, Yuming Zhou and Yiwei Zhang

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202404123

The Role of Diastereomer Impurity in Oiling-Out during the Resolution of trans-4-Methyl-2-piperidine Carboxylic Ethyl Ester Enantiomers by Crystallization

Riju Ren, Dengqiong Sun, Tingting Wei, Shixin Zhang and Junbo Gong

Org. Process Res. Dev., 2014, 18, 709
DOI: 10.1021/op500026z

Mode of Action and Design Rules for Additives That Modulate Crystal Nucleation

Jamshed Anwar, Papa Kofi Boateng, Reiko Tamaki and Sheetal Odedra

Angewandte Chemie, 2009, 121, 1624
DOI: 10.1002/ange.200804553

Drug–Polymer Nanodroplet Formation and Morphology Drive Solubility Enhancement of GDC-0810

Kaylee E. Barr, Monica L. Ohnsorg, Lucy Liberman, Louis G. Corcoran, Apoorva Sarode, Karthik Nagapudi, Christina R. Feder, Frank S. Bates and Theresa M. Reineke

Bioconjugate Chem., 2024, 35, 499
DOI: 10.1021/acs.bioconjchem.4c00018

250 nm Glycine-Rich Nanodroplets Are Formed on Dissolution of Glycine Crystals But Are Too Small To Provide Productive Nucleation Sites

Anna Jawor-Baczynska, Jan Sefcik and Barry D. Moore

Crystal Growth & Design, 2013, 13, 470
DOI: 10.1021/cg300150u

Crystallization of an active pharmaceutical ingredient that oils out

Jie Lu, Yi-Ping Li, Jing Wang, Guo-Bin Ren, Sohrab Rohani and Chi-Bun Ching

Separation and Purification Technology, 2012, 96, 1
DOI: 10.1016/j.seppur.2012.05.015

A dual growth mode unique for organic crystals relies on mesoscopic liquid precursors

Manasa Yerragunta, Akash Tiwari, Rajshree Chakrabarti, Jeffrey D. Rimer, Bart Kahr and Peter G. Vekilov

Commun Chem, 2024, 7
DOI: 10.1038/s42004-024-01275-3

Crystallisation of organic materials from the solution phase: a molecular, synthonic and crystallographic perspective

Nornizar Anuar, Siti Nurul’ain Yusop and Kevin J. Roberts

Crystallography Reviews, 2022, 28, 97
DOI: 10.1080/0889311X.2022.2123916

High-pressure crystallization and melting of polyethylene in n-pentane

Wei Zhang and Erdogan Kiran

The Journal of Supercritical Fluids, 2006, 38, 406
DOI: 10.1016/j.supflu.2005.12.017

Solution Crystallization of Vanillin in the Presence of a Liquid–Liquid Phase Separation

Haiping Zhao, Chuang Xie, Zhao Xu, Yongli Wang, Lin Bian, Zhen Chen and Hongxun Hao

Ind. Eng. Chem. Res., 2012, 51, 14646
DOI: 10.1021/ie302360u

A Pathway to First Crystals for Substances Prone to Liquid‐Liquid Phase Separation

Lotfi Derdour

Chem Eng & Technol, 2021, 44, 488
DOI: 10.1002/ceat.202000274

Approaches to increase mechanistic understanding and aid in the selection of precipitation inhibitors for supersaturating formulations – a PEARRL review

Daniel J Price, Felix Ditzinger, Niklas J Koehl, Sandra Jankovic, Georgia Tsakiridou, Anita Nair, René Holm, Martin Kuentz, Jennifer B Dressman and Christoph Saal

Journal of Pharmacy and Pharmacology, 2019, 71, 483
DOI: 10.1111/jphp.12927

Effect of Solution Composition on Impurity Profile of the Crystallized Product in Oiling-Out Crystallization

Kota Tanaka and Hiroshi Takiyama

Chem. Pharm. Bull., 2020, 68, 326
DOI: 10.1248/cpb.c19-01015

Kinetics and equilibria of lysozyme precipitation and crystallization in concentrated ammonium sulfate solutions

Yu‐Chia Cheng, Raul F. Lobo, Stanley I. Sandler and Abraham M. Lenhoff

Biotech & Bioengineering, 2006, 94, 177
DOI: 10.1002/bit.20839

The Crystallization of Active Pharmaceutical Ingredients with Low Melting Points in the Presence of Liquid–Liquid Phase Separation

Wei Han Lin, Zai-Qun Yu, Pui Shan Chow and Reginald Beng Hee Tan

Crystals, 2021, 11, 1326
DOI: 10.3390/cryst11111326

A Thermodynamic Approach for the Prediction of Oiling Out Boundaries from Solubility Data

Venkateswarlu Bhamidi and Brendan P. Abolins

Processes, 2019, 7, 577
DOI: 10.3390/pr7090577

Molecular Clustering of Fenoxycarb and Salicylic Acid in Organic Solvents and Relation to Crystal Nucleation

Shubhangi Kakkar, Krishnaraj Renuka Devi and Åke C. Rasmuson

Crystal Growth & Design, 2022, 22, 2824
DOI: 10.1021/acs.cgd.1c00913

Application of a Semiautomated Crystallizer to Study Oiling-Out and Agglomeration Events—A Case Study in Industrial Crystallization Optimization

Xiaowen Zhao, Nicola J. Webb, Mark P. Muehlfeld, Alan L. Stottlemyer and Matthew W. Russell

Org. Process Res. Dev., 2021, 25, 564
DOI: 10.1021/acs.oprd.0c00494

Nucleation

Peter G. Vekilov

Crystal Growth & Design, 2010, 10, 5007
DOI: 10.1021/cg1011633

Observation of crystallisation dynamics by crystal-structure-sensitive room-temperature phosphorescence from Au(I) complexes

Yuki Kuroda, Masakazu Tamaru, Hitoya Nakasato, Kyosuke Nakamura, Manami Nakata, Kyohei Hisano, Kaori Fujisawa and Osamu Tsutsumi

Commun Chem, 2020, 3
DOI: 10.1038/s42004-020-00382-1

Complex structures arising from the self-assembly of a simple organic salt

Riccardo Montis, Luca Fusaro, Andrea Falqui, Michael B. Hursthouse, Nikolay Tumanov, Simon J. Coles, Terry L. Threlfall, Peter N. Horton, Rachid Sougrat, Anaïs Lafontaine, Gérard Coquerel and A. David Rae

Nature, 2021, 590, 275
DOI: 10.1038/s41586-021-03194-y

Oiling-Out: Insights from Gibbsian Surface Thermodynamics by Stability Analysis

Shima Khodarahmi, Fatemeh Eslami and Leila Zargarzadeh

Langmuir, 2024, 40, 4669
DOI: 10.1021/acs.langmuir.3c03329

Antisolvent Crystallization of Erythromycin Ethylsuccinate in the Presence of Liquid–Liquid Phase Separation

Xiang Li, Qiuxiang Yin, Meijin Zhang, Baohong Hou, Ying Bao, Junbo Gong, Hongxun Hao, Yongli Wang, Jingkang Wang and Zhao Wang

Ind. Eng. Chem. Res., 2016, 55, 766
DOI: 10.1021/acs.iecr.5b04155

Predicting the Solubility Advantage of Amorphous Pharmaceuticals: A Novel Thermodynamic Approach

Raphael Paus, Yuanhui Ji, Lisa Vahle and Gabriele Sadowski

Mol. Pharmaceutics, 2015, 12, 2823
DOI: 10.1021/mp500824d

Amorphous solubility advantage: Theoretical considerations, experimental methods, and contemporary relevance

Keisuke Ueda, Dana E. Moseson and Lynne S. Taylor

Journal of Pharmaceutical Sciences, 2025, 114, 18
DOI: 10.1016/j.xphs.2024.08.029

Experimental determination of solid‐liquid‐liquid equilibrium phase diagrams

Sau M. Lai, Mai Y. Yuen, Leo K. S. Siu, Ka M. Ng and Christianto Wibowo

AIChE Journal, 2007, 53, 1608
DOI: 10.1002/aic.11183

Experimental investigation and prediction of oiling out during crystallization process

Kai Kiesow, Feelly Tumakaka and Gabriele Sadowski

Journal of Crystal Growth, 2008, 310, 4163
DOI: 10.1016/j.jcrysgro.2008.06.034

Molecular Dynamics Simulation on Nucleation of Ammonium Perchlorate from an Aqueous Solution

Hong-Min Shim, Jae-Kyeong Kim, Hyoun-Soo Kim and Kee-Kahb Koo

Crystal Growth & Design, 2014, 14, 5897
DOI: 10.1021/cg501112a

How To Use the Lasentec FBRM Probe on Manufacturing Scale

Neil K. Adlington, Simon N. Black and David L. Adshead

Org. Process Res. Dev., 2013, 17, 557
DOI: 10.1021/op300326b

A nonclassical pathway of β-hematin crystal nucleation enables its suppression by antimalarials

Wenchuan Ma, Lakshmanji Verma, Huan-Jui Lee, Weichun Pan, Michael B. Sherman, David J. Sullivan, Jeffrey D. Rimer, Jeremy C. Palmer and Peter G. Vekilov

Commun Chem, 2025, 8
DOI: 10.1038/s42004-025-01612-0

Nucleation of protein crystals

Peter G. Vekilov

Progress in Crystal Growth and Characterization of Materials, 2016, 62, 136
DOI: 10.1016/j.pcrysgrow.2016.04.007

Effect of Oiling-Out during Crystallization on Purification of an Intermediate Compound

Kota Tanaka and Hiroshi Takiyama

Org. Process Res. Dev., 2019, 23, 2001
DOI: 10.1021/acs.oprd.9b00256

Impact of degree of supersaturation on the dissolution and oral absorption behaviors of griseofulvin amorphous solid dispersions

Kohsaku Kawakami, Kyosuke Suzuki, Masafumi Fukiage, Maki Matsuda, Yohei Nishida, Michinori Oikawa and Takuya Fujita

Journal of Drug Delivery Science and Technology, 2020, 56, 101172
DOI: 10.1016/j.jddst.2019.101172

Keimbildung organischer Kristalle aus molekularer Sichtweise

Roger J. Davey, Sven L. M. Schroeder and Joop H. ter Horst

Angewandte Chemie, 2013, 125, 2220
DOI: 10.1002/ange.201204824

A review on possible mechanisms of sonocrystallisation in solution

Silvia Nalesso, Madeleine J. Bussemaker, Richard P. Sear, Mark Hodnett and Judy Lee

Ultrasonics Sonochemistry, 2019, 57, 125
DOI: 10.1016/j.ultsonch.2019.04.020

Liquid–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs: Implications for Solubility Enhancing Formulations

Grace A. Ilevbare and Lynne S. Taylor

Crystal Growth & Design, 2013, 13, 1497
DOI: 10.1021/cg301679h

Metastable Mesoscopic Phases in Concentrated Protein Solutions

Peter G. Vekilov

Annals of the New York Academy of Sciences, 2009, 1161, 377
DOI: 10.1111/j.1749-6632.2008.04318.x

Control of Liquid–Liquid Phase Separation, Nucleation, and Growth of L‐Menthol Single Crystals from Water–Ethanol Solvent Mixtures

Kowsalya Murugan and Srinivasan Karuppannan

Cryst. Res. Technol., 2024, 59
DOI: 10.1002/crat.202300327

Trends in the Precipitation and Crystallization Behavior of Supersaturated Aqueous Solutions of Poorly Water-Soluble Drugs Assessed Using Synchrotron Radiation

Shweta A. Raina, Bernard Van Eerdenbrugh, David E. Alonzo, Huaping Mo, Geoff G.Z. Zhang, Yi Gao and Lynne S. Taylor

Journal of Pharmaceutical Sciences, 2015, 104, 1981
DOI: 10.1002/jps.24423

Nucleation and growth in solution synthesis of nanostructures – From fundamentals to advanced applications

Ke-Jun Wu, Edmund C.M. Tse, Congxiao Shang and Zhengxiao Guo

Progress in Materials Science, 2022, 123, 100821
DOI: 10.1016/j.pmatsci.2021.100821

Crystallization Process Design Using Thermodynamics To Avoid Oiling Out in a Mixture of Vanillin and Water

Ian de Albuquerque and Marco Mazzotti

Crystal Growth & Design, 2014, 14, 5617
DOI: 10.1021/cg500904v

Drug-Rich Phases Induced by Amorphous Solid Dispersion: Arbitrary or Intentional Goal in Oral Drug Delivery?

Kaijie Qian, Lorenzo Stella, David S. Jones, Gavin P. Andrews, Huachuan Du and Yiwei Tian

Pharmaceutics, 2021, 13, 889
DOI: 10.3390/pharmaceutics13060889

Nonphotochemical Laser Induced Nucleation of Hen Egg White Lysozyme Crystals

In Sung Lee, James M. B. Evans, Deniz Erdemir, Alfred Y. Lee, Bruce A. Garetz and Allan S. Myerson

Crystal Growth & Design, 2008, 8, 4255
DOI: 10.1021/cg800696u

An In-Line Study of Oiling Out and Crystallization

Emilie Deneau and Gerry Steele

Org. Process Res. Dev., 2005, 9, 943
DOI: 10.1021/op050107c

Nucleation of Organic Crystals—A Molecular Perspective

Roger J. Davey, Sven L. M. Schroeder and Joop H. ter Horst

Angew Chem Int Ed, 2013, 52, 2166
DOI: 10.1002/anie.201204824

Study on the Oiling-out and Crystallization for the Purification of Idebenone

Jie Lu, Yi-Ping Li, Jing Wang, Zhen Li, Sohrab Rohani and Chi-Bun Ching

Org. Process Res. Dev., 2012, 16, 442
DOI: 10.1021/op200339a

Regions of attainable particle sizes in continuous and batch crystallization processes

Thomas Vetter, Christopher L. Burcham and Michael F. Doherty

Chemical Engineering Science, 2014, 106, 167
DOI: 10.1016/j.ces.2013.11.008

Dense Liquid Precursor for the Nucleation of Ordered Solid Phases from Solution

Peter G. Vekilov

Crystal Growth & Design, 2004, 4, 671
DOI: 10.1021/cg049977w

In situ monitoring, control and optimization of a liquid–liquid phase separation crystallization

D. Duffy, N. Cremin, M. Napier, S. Robinson, M. Barrett, Hongxun Hao and Brian Glennon

Chemical Engineering Science, 2012, 77, 112
DOI: 10.1016/j.ces.2012.01.047

pH-Dependent Liquid–Liquid Phase Separation of Highly Supersaturated Solutions of Weakly Basic Drugs

Anura S. Indulkar, Karl J. Box, Robert Taylor, Rebeca Ruiz and Lynne S. Taylor

Mol. Pharmaceutics, 2015, 12, 2365
DOI: 10.1021/acs.molpharmaceut.5b00056

From Experiments and Models to Business Decisions: A Scale-up Study on the Reactive Crystallization of a Crop Protection Agent

Venkateswarlu Bhamidi, Kim Dumoleijn, Debangshu Guha, Shane K. Kirk, Alain De Bruyn and Allison K. Pymer

Org. Process Res. Dev., 2019, 23, 342
DOI: 10.1021/acs.oprd.8b00384

Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses

Marival Bermejo, Gislaine Kuminek, Jozef Al-Gousous, Alejandro Ruiz-Picazo, Yasuhiro Tsume, Alfredo Garcia-Arieta, Isabel González-Alvarez, Bart Hens, Deanna Mudie, Gregory E. Amidon, Nair Rodriguez-Hornedo and Gordon L. Amidon

Pharmaceutics, 2019, 11, 122
DOI: 10.3390/pharmaceutics11030122

Investigation of Batch Cooling Crystallization in a Liquid–Liquid Separating System by PAT

Huaiyu Yang and Åke C. Rasmuson

Org. Process Res. Dev., 2012, 16, 1212
DOI: 10.1021/op200355b

Mechanistic understanding of the phase behavior of supersaturated solutions of poorly water-soluble drugs

Francesco Tres, Maria M. Posada, Stephen D. Hall, Michael A. Mohutsky and Lynne S. Taylor

International Journal of Pharmaceutics, 2018, 543, 29
DOI: 10.1016/j.ijpharm.2018.03.038

The Nucleation and Growth of Succinic Acid in the Presence of Surfactants

Qiushuo Yu, Xiaorui Li, Xiaoyan Qiao and Min Qi

J Surfact & Detergents, 2017, 20, 1351
DOI: 10.1007/s11743-017-1999-8

Operation Strategy for Avoiding Oiling‐Out During the Anti‐Solvent Crystallization Based on Ternary Phase Diagram

Shuntaro Amari, Ai Okude, Shoji Kudo and Hiroshi Takiyama

ChemistrySelect, 2022, 7
DOI: 10.1002/slct.202203181

Prediction of the phase diagram of liquid–liquid phase separation during crystallization via a molecular mechanism study

Yanbo Liu, Jinbo Ouyang, Xuemei Wei, Guoqi Yu, Hualiang Shen, Runpu Shen, Xin Zhang, Weiwei Tang, Mingyang Chen, Kangli Li and Junbo Gong

Journal of Molecular Liquids, 2023, 387, 122634
DOI: 10.1016/j.molliq.2023.122634

Tracking Prenucleation Molecular Clustering of Salicylamide in Organic Solvents

Shubhangi Kakkar, Shayon Bhattacharya, Pierre-André Cazade, Damien Thompson and Åke Rasmuson

Crystal Growth & Design, 2024, 24, 5740
DOI: 10.1021/acs.cgd.4c00507

Nucleation and growth by diffusion under Ostwald-Freundlich boundary condition

Masao Iwamatsu

The Journal of Chemical Physics, 2014, 140
DOI: 10.1063/1.4865108

Oiling‐Out Crystallization of Beta‐Alanine on Solid Surfaces Controlled by Solvent Exchange

Xuehua Zhang, Zixiang Wei, Howon Choi, Hao Hao and Huaiyu Yang

Adv Materials Inter, 2021, 8
DOI: 10.1002/admi.202001200

Precipitation mechanism of stable and metastable polymorphs of L‐glutamic acid

C. P. Mark Roelands, Joop H. ter Horst, Herman J. M. Kramer and Pieter J. Jansens

AIChE Journal, 2007, 53, 354
DOI: 10.1002/aic.11072

Probing Crystal Nucleation from Fluid Phases: The Nucleation of para-Azoxyanisole from Its Nematic Liquid Crystalline State

Sophie Janbon, Roger J. Davey and Geoffrey Dent

J. Phys. Chem. C, 2008, 112, 15771
DOI: 10.1021/jp801676w

Thermodynamics and Kinetics of Prenucleation Clusters, Classical and Non‐Classical Nucleation

Dirk Zahn

ChemPhysChem, 2015, 16, 2069
DOI: 10.1002/cphc.201500231

Solute interaction-driven and solvent interaction-driven liquid–liquid phase separation induced by molecular size difference

Yuya Iida, Shotaro Hiraide, Minoru T. Miyahara and Satoshi Watanabe

The Journal of Chemical Physics, 2024, 160
DOI: 10.1063/5.0190119

Oiling‐Out in Industrial Crystallization of Organic Small Molecules: Mechanisms, Characterization, Regulation, and Applications

Shilei Zhou, Zhenkai Cen, Dandan Han, Bowen Zhang and Junbo Gong

Cryst. Res. Technol., 2024, 59
DOI: 10.1002/crat.202400092

Liquid–liquid phase separation in pharmaceutical crystallization

Zai-Qun Yu, Fang-Kun Zhang and Reginald Beng Hee Tan

Chemical Engineering Research and Design, 2021, 174, 19
DOI: 10.1016/j.cherd.2021.07.028

Emulsion crystallization of phenanthrene by supercritical fluid extraction of emulsions

Johannes Kluge, Lisa Joss, Sebastian Viereck and Marco Mazzotti

Chemical Engineering Science, 2012, 77, 249
DOI: 10.1016/j.ces.2011.12.008

Oiling out and Polymorphism Control of Pyraclostrobin in Cooling Crystallization

Kangli Li, Songgu Wu, Shijie Xu, Shichao Du, Kaifei Zhao, Lanlan Lin, Peng Yang, Bo Yu, Baohong Hou and Junbo Gong

Ind. Eng. Chem. Res., 2016, 55, 11631
DOI: 10.1021/acs.iecr.6b03097

In Situ Monitoring of Stirring Effects on Polymorphic Transformations during Cooling Crystallization of Carbamazepine

Katarzyna Sypek, Iain S. Burns, Alastair J. Florence and Jan Sefcik

Crystal Growth & Design, 2012, 12, 4821
DOI: 10.1021/cg3005689

A Practical Approach for Using Solubility to Design Cooling Crystallisations

Frans L. Muller, Mark Fielding and Simon Black

Org. Process Res. Dev., 2009, 13, 1315
DOI: 10.1021/op9001438

Assessment of Recent Process Analytical Technology (PAT) Trends: A Multiauthor Review

Levente L. Simon, Hajnalka Pataki, György Marosi, Fabian Meemken, Konrad Hungerbühler, Alfons Baiker, Srinivas Tummala, Brian Glennon, Martin Kuentz, Gerry Steele, Herman J. M. Kramer, James W. Rydzak, Zengping Chen, Julian Morris, Francois Kjell, Ravendra Singh, Rafiqul Gani, Krist V. Gernaey, Marjatta Louhi-Kultanen, John O’Reilly, Niklas Sandler, Osmo Antikainen, Jouko Yliruusi, Patrick Frohberg, Joachim Ulrich, Richard D. Braatz, Tom Leyssens, Moritz von Stosch, Rui Oliveira, Reginald B. H. Tan, Huiquan Wu, Mansoor Khan, Des O’Grady, Anjan Pandey, Remko Westra, Emmanuel Delle-Case, Detlef Pape, Daniele Angelosante, Yannick Maret, Olivier Steiger, Miklós Lenner, Kaoutar Abbou-Oucherif, Zoltan K. Nagy, James D. Litster, Vamsi Krishna Kamaraju and Min-Sen Chiu

Org. Process Res. Dev., 2015, 19, 3
DOI: 10.1021/op500261y

Crystallization and nucleation mechanism of heavy hydrocarbons in natural gas

Dan Guo, Xuewen Cao, Gaoya Ding, Pan Zhang, Yang Liu and Jiang Bian

Energy, 2022, 239, 122071
DOI: 10.1016/j.energy.2021.122071

Crystallization: Key thermodynamic, kinetic and hydrodynamic aspects

SREEPRIYA VEDANTAM and VIVEK V RANADE

Sadhana, 2013, 38, 1287
DOI: 10.1007/s12046-013-0195-4

Mesoscopic Solute-Rich Clusters in Olanzapine Solutions

Monika Warzecha, Mohammad S. Safari, Alastair J. Florence and Peter G. Vekilov

Crystal Growth & Design, 2017, 17, 6668
DOI: 10.1021/acs.cgd.7b01299

Uncovering Molecular Processes in Crystal Nucleation and Growth by Using Molecular Simulation

Jamshed Anwar and Dirk Zahn

Angew Chem Int Ed, 2011, 50, 1996
DOI: 10.1002/anie.201000463

A method to crystallize substances that oil out

L. Derdour

Chemical Engineering Research and Design, 2010, 88, 1174
DOI: 10.1016/j.cherd.2010.02.001

Effective Control of Liquid–Liquid Phase Separation and Nucleation of Vanillin Single Crystals through a Vapor Diffusion Crystallization Process in Selected Solvent Environments

S. Supriya, S. Sushmitha and K. Srinivasan

Crystal Growth & Design, 2019, 19, 6315
DOI: 10.1021/acs.cgd.9b00798

Liquid‐liquid phase separation in acetone solutions of palm olein: Implications for solvent fractionation

Kevin W. Smith, Fred W. Cain, Loek Favre and Geoff Talbot

Euro J Lipid Sci & Tech, 2007, 109, 350
DOI: 10.1002/ejlt.200600237

Control of Crystal Size during Oiling Out Crystallization of an API

Masahiro Takasuga and Hiroshi Ooshima

Crystal Growth & Design, 2014, 14, 6006
DOI: 10.1021/cg5011874

Highly Selective, Kinetically Driven Polymorphic Selection in Microfluidic Emulsion-Based Crystallization and Formulation

Reno A. L. Leon, Abu Zayed M. Badruddoza, Lu Zheng, Eunice W. Q. Yeap, Arpad I. Toldy, Kay Yan Wong, T. Alan Hatton and Saif A. Khan

Crystal Growth & Design, 2015, 15, 212
DOI: 10.1021/cg501222n

Crystallization and Polymorphism under Nanoconfinement

Noalle Fellah, Isaac Jerome C. Dela Cruz, Bryan G. Alamani, Alex G. Shtukenberg, Ajinkya V. Pandit, Michael D. Ward and Allan S. Myerson

Crystal Growth & Design, 2024, 24, 3527
DOI: 10.1021/acs.cgd.3c01082

Phase Diagram of a Chiral Substance Exhibiting Oiling Out. 2. Racemic Compound Forming Ibuprofen in Water

Lorenzo Codan, Stefania Casillo, Matthäus Ulrich Bäbler and Marco Mazzotti

Crystal Growth & Design, 2012, 12, 5298
DOI: 10.1021/cg300890u

Phase Diagram of a Chiral Substance Exhibiting Oiling Out in Cyclohexane

Lorenzo Codan, Matthäus U. Bäbler and Marco Mazzotti

Crystal Growth & Design, 2010, 10, 4005
DOI: 10.1021/cg100605t

A Metastable Amorphous Intermediate Is Responsible for Laser-Induced Nucleation of Glycine

Zhiyu Liao and Klaas Wynne

J. Am. Chem. Soc., 2022, 144, 6727
DOI: 10.1021/jacs.1c11154

Enhanced Crystal Growth in Binary Lennard-Jones Mixtures

M. Radu and K. Kremer

Phys. Rev. Lett., 2017, 118
DOI: 10.1103/PhysRevLett.118.055702

Molecular Dynamics Investigation of Clustering in Aqueous Glycine Solutions

Martin B. Sweatman, Nasser D. Afify, Carlos A. Ferreiro-Rangel, Miguel Jorge and Jan Sefcik

J. Phys. Chem. B, 2022, 126, 4711
DOI: 10.1021/acs.jpcb.2c01975

Bottom‐up Growth of Convex Sphere with Adjustable Cu(0)/Cu(I) Interfaces for Effective C2 Production from CO2 Electroreduction

Huan Liu, Chenghan Yang, Tong Bian, Huijun Yu, Yuming Zhou and Yiwei Zhang

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202404123

Chemically Specific Coherent Raman Imaging of Liquid–Liquid Phase Separation and Its Sequelae

Alba M. Arbiol Enguita, Laurin Zöller, Teemu Tomberg, Mikko J. Heikkilä, Jukka K. S. Saarinen, Lea Wurr, Tom Konings, Alexandra Correia, Christoph Saal, Jennifer Dressman and Clare J. Strachan

Anal. Chem., 2025, 97, 3242
DOI: 10.1021/acs.analchem.4c03923

The Investigation of Flory–Huggins Interaction Parameters for Amorphous Solid Dispersion Across the Entire Temperature and Composition Range

Yiwei Tian, Kaijie Qian, Esther Jacobs, Esther Amstad, David S. Jones, Lorenzo Stella and Gavin P. Andrews

Pharmaceutics, 2019, 11, 420
DOI: 10.3390/pharmaceutics11080420

Crystallization in the presence of impurities: mechanisms, models and controls

Baggie W. Nyande, Samir Diab, Helen Yao, Richard Lakerveld and Zoltan K. Nagy

Chemical Engineering Research and Design, 2025, 221, 525
DOI: 10.1016/j.cherd.2025.08.002

Solubility and Some Crystallization Properties of Conglomerate Forming Chiral Drug Guaifenesin in Water

Robert R. Fayzullin, Heike Lorenz, Zemfira A. Bredikhina, Alexander A. Bredikhin and Andreas Seidel-Morgenstern

Journal of Pharmaceutical Sciences, 2014, 103, 3176
DOI: 10.1002/jps.24104

Review of Liquid–Liquid Phase Separation in Crystallization: From Fundamentals to Application

Shijie Xu, Huimin Zhang, Bige Qiao and Yanfei Wang

Crystal Growth & Design, 2021, 21, 7306
DOI: 10.1021/acs.cgd.0c01376

Characterization of Supersaturated Danazol Solutions – Impact of Polymers on Solution Properties and Phase Transitions

Matthew J. Jackson, Umesh S. Kestur, Munir A. Hussain and Lynne S. Taylor

Pharm Res, 2016, 33, 1276
DOI: 10.1007/s11095-016-1871-y

The non-classical nucleation of crystals: microscopic mechanisms and applications to molecular crystals, ice and calcium carbonate

R P Sear

International Materials Reviews, 2012, 57, 328
DOI: 10.1179/1743280411Y.0000000015

Atomistisches Verständnis der Keimbildung und des Kristallwachstums durch molekulare Simulationen

Jamshed Anwar and Dirk Zahn

Angewandte Chemie, 2011, 123, 2042
DOI: 10.1002/ange.201000463

Non-Photochemical Pulsed-Laser-Induced Nucleation in a Continuous-Wave-Laser-Induced Phase-Separated Solution Droplet of Aqueous Glycine Formed by Optical Gradient Forces

Omar Gowayed, Tasfia Tasnim, José J. Fuentes-Rivera, Janice E. Aber and Bruce A. Garetz

Crystal Growth & Design, 2019, 19, 7372
DOI: 10.1021/acs.cgd.9b01255

Study of liquid–liquid demixing from drug solution

Laurent Lafferrère, Christian Hoff and Stéphane Veesler

Journal of Crystal Growth, 2004, 269, 550
DOI: 10.1016/j.jcrysgro.2004.05.048

Sodium Lauryl Sulfate Competitively Interacts with HPMC-AS and Consequently Reduces Oral Bioavailability of Posaconazole/HPMC-AS Amorphous Solid Dispersion

Yuejie Chen, Shujing Wang, Shan Wang, Chengyu Liu, Ching Su, Michael Hageman, Munir Hussain, Roy Haskell, Kevin Stefanski and Feng Qian

Mol. Pharmaceutics, 2016, 13, 2787
DOI: 10.1021/acs.molpharmaceut.6b00391

Process Design for Antisolvent Crystallization of Erythromycin Ethylsuccinate in Oiling-out System

Xiang Li, Qiuxiang Yin, Meijing Zhang, Baohong Hou, Ying Bao, Junbo Gong, Hongxun Hao, Yongli Wang, Jingkang Wang and Zhao Wang

Ind. Eng. Chem. Res., 2016, 55, 7484
DOI: 10.1021/acs.iecr.6b00795

Role of Ultrasound on the Control of Liquid–Liquid Phase Separation and Nucleation of l-Menthol Polymorphs

Kowsalya Murugan and Srinivasan Karuppannan

Crystal Growth & Design, 2025, 25, 4823
DOI: 10.1021/acs.cgd.5c00304

Role of Polymer Excipients in the Kinetic Stabilization of Drug-Rich Nanoparticles

Nicholas J. Van Zee, Marc A. Hillmyer and Timothy P. Lodge

ACS Appl. Bio Mater., 2020, 3, 7243
DOI: 10.1021/acsabm.0c01173

Millimeter-Scale Dense Liquid Droplet Formation and Crystallization in Glycine Solution Induced by Photon Pressure

Ken-ichi Yuyama, Teruki Sugiyama and Hiroshi Masuhara

J. Phys. Chem. Lett., 2010, 1, 1321
DOI: 10.1021/jz100266t

Control of Crystal Aspect Ratio and Size by Changing Solvent Composition in Oiling Out Crystallization of an Active Pharmaceutical Ingredient

Masahiro Takasuga and Hiroshi Ooshima

Crystal Growth & Design, 2015, 15, 5834
DOI: 10.1021/acs.cgd.5b01192

Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

Huaiyu Yang and Åke C. Rasmuson

Fluid Phase Equilibria, 2015, 385, 120
DOI: 10.1016/j.fluid.2014.11.007

In Situ Monitoring of the Impact of Liquid−Liquid Phase Separation on Drug Crystallization by Seeding

Laurent Lafferrère, Christian Hoff and Stéphane Veesler

Crystal Growth & Design, 2004, 4, 1175
DOI: 10.1021/cg0497750

Dissolution of Danazol Amorphous Solid Dispersions: Supersaturation and Phase Behavior as a Function of Drug Loading and Polymer Type

Matthew J. Jackson, Umesh S. Kestur, Munir A. Hussain and Lynne S. Taylor

Mol. Pharmaceutics, 2016, 13, 223
DOI: 10.1021/acs.molpharmaceut.5b00652

Mode of Action and Design Rules for Additives That Modulate Crystal Nucleation

Jamshed Anwar, Papa Kofi Boateng, Reiko Tamaki and Sheetal Odedra

Angew Chem Int Ed, 2009, 48, 1596
DOI: 10.1002/anie.200804553

pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

Yi-Ling Hsieh, Grace A. Ilevbare, Bernard Van Eerdenbrugh, Karl J. Box, Manuel Vincente Sanchez-Felix and Lynne S. Taylor

Pharm Res, 2012, 29, 2738
DOI: 10.1007/s11095-012-0759-8

The Ambiguous Functions of the Precursors That Enable Nonclassical Modes of Olanzapine Nucleation and Growth

Monika Warzecha, Alastair J. Florence and Peter G. Vekilov

Crystals, 2021, 11, 738
DOI: 10.3390/cryst11070738

A Robust Three-Step Telescoped Synthesis of Electron- Deficient Amide Substituted Arylboronic Acids

Jason Zhu, Thomas M. Razler, Zhongmin Xu, David A. Conlon, Eric W. Sortore, Alan W. Fritz, Roman Demerzhan and Jason T. Sweeney

Org. Process Res. Dev., 2011, 15, 438
DOI: 10.1021/op100267p

Effect of the range of repulsions on the existence of a stable liquid phase

Ryan J. Larsen and Charles F. Zukoski

The Journal of Chemical Physics, 2012, 136
DOI: 10.1063/1.3679169

Nucleation in aqueous NaCl solutions shifts from 1-step to 2-step mechanism on crossing the spinodal

Hao Jiang, Pablo G. Debenedetti and Athanassios Z. Panagiotopoulos

The Journal of Chemical Physics, 2019, 150
DOI: 10.1063/1.5084248

Investigation of molecular and mesoscale clusters in undersaturated glycine aqueous solutions

Georgina Zimbitas, Anna Jawor-Baczynska, Maria Jazmin Vesga, Nadeem Javid, Barry D. Moore, John Parkinson and Jan Sefcik

Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2019, 579, 123633
DOI: 10.1016/j.colsurfa.2019.123633

The Very Different Effect of Water on Nucleation, Crystallization, and Hydrate Stability of Zingerone and Vanillate Esters

Marwah Aljohani, Patrick McArdle and Andrea Erxleben

Crystal Growth & Design, 2020, 20, 627
DOI: 10.1021/acs.cgd.9b00960

Metastable Liquid Clusters in Super- and Undersaturated Protein Solutions

Olga Gliko, Weichun Pan, Panagiotis Katsonis, Nikolaus Neumaier, Oleg Galkin, Sevil Weinkauf and Peter G. Vekilov

J. Phys. Chem. B, 2007, 111, 3106
DOI: 10.1021/jp068827o

Glass–Liquid Phase Separation in Highly Supersaturated Aqueous Solutions of Telaprevir

Laura I. Mosquera-Giraldo and Lynne S. Taylor

Mol. Pharmaceutics, 2015, 12, 496
DOI: 10.1021/mp500573z

Formation and Evolution of Nanoscale Calcium Phosphate Precursors under Biomimetic Conditions

Ludovica M. Epasto, Tristan Georges, Albina Selimović, Jean-Michel Guigner, Thierry Azaïs and Dennis Kurzbach

Anal. Chem., 2021, 93, 10204
DOI: 10.1021/acs.analchem.1c01561

Nonclassical Crystallization and Core–Shell Structure Formation of Ibuprofen from Binary Solvent Solutions

Rajaboopathi Mani, Leena Peltonen, Clare J. Strachan, Maarit Karppinen and Marjatta Louhi-Kultanen

Crystal Growth & Design, 2023, 23, 236
DOI: 10.1021/acs.cgd.2c00971

Two-step mechanism for the nucleation of crystals from solution

Peter G. Vekilov

Journal of Crystal Growth, 2005, 275, 65
DOI: 10.1016/j.jcrysgro.2004.10.068

Crystal Growth, Structure, and Polymorphic Behavior of an Ionic Liquid: Phthalate Derivative of N-Butyl,N-methylimidazolium Hexafluorophosphate

Clément Brandel, Gabin Gbabode, Yohann Cartigny, Claudette Martin, Géraldine Gouhier, Samuel Petit and Gérard Coquerel

Chem. Mater., 2014, 26, 4151
DOI: 10.1021/cm501220x

Oiling-Out Investigation and Morphology Control of β-Alanine Based on Ternary Phase Diagrams

Mengmeng Sun, Shichao Du, Mingyang Chen, Sohrab Rohani, Huihui Zhang, Ya Liu, PanPan Sun, Yaping Wang, Peng Shi, Shijie Xu and Junbo Gong

Crystal Growth & Design, 2018, 18, 818
DOI: 10.1021/acs.cgd.7b01293

Mesoscopic Solute-Rich Clusters in Organic Solutions

Manasa Yerragunta, Alejandro C. Veliz, Monika Warzecha, Viktor G. Hadjiev, Alastair J. Florence, Gül H. Zerze, Jeffrey D. Rimer and Peter G. Vekilov

Crystal Growth & Design, 2025, 25, 3958
DOI: 10.1021/acs.cgd.5c00370