Issue 91, 2022

Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker sensing

Abstract

Herein, we develop a hierarchically mesoporous cerium metal–organic framework (Ce-HMMOF) nanozyme with enhanced ALP-mimicking activity for the naked-eye detection of phosphorylated biomarkers. The long-range ordered mesochannels (9.18 nm) throughout the Ce-HMMOF promote both the mass transfer and the accessibility of interior active sites, permitting the rapid and sensitive sensing of phosphorylated biomarkers through ALP-like biocatalysis. This work provides a new insight into the engineering of highly active nanozymes for disease-associated biomarker screening and diagnosis.

Graphical abstract: Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker sensing

Supplementary files

Article information

Article type
Communication
Submitted
04 Sep 2022
Accepted
21 Okt 2022
First published
21 Okt 2022

Chem. Commun., 2022,58, 12720-12723

Hierarchically mesoporous Ce-based MOFs with enhanced alkaline phosphatase-like activity for phosphorylated biomarker sensing

R. Gao, N. Ye, X. Kou, Y. Shen, H. Yang, T. Wu, S. Huang, G. Chen and G. Ouyang, Chem. Commun., 2022, 58, 12720 DOI: 10.1039/D2CC04895G

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