Issue 29, 2018

The aerolysin nanopore: from peptidomic to genomic applications

Abstract

The aerolysin pore (ARP) is a newly emerging nanopore that has been extensively used for peptide and protein sensing. Recently, several groups have explored the application of ARP in detecting genetic and epigenetic markers. This brief review summarizes the current applications of ARP, progressing from peptidomic to genomic detection; the recently reported site-directed mutagenesis of ARP; and new genomic DNA sensing approaches, and their advantages and disadvantages. This review will also discuss the perspectives and future applications of ARP for nucleic acid sequencing and biomolecule sensing.

Graphical abstract: The aerolysin nanopore: from peptidomic to genomic applications

Article information

Article type
Minireview
Submitted
25 Mai 2018
Accepted
25 Jun 2018
First published
25 Jun 2018

Nanoscale, 2018,10, 13857-13866

The aerolysin nanopore: from peptidomic to genomic applications

Y. Wang, L. Gu and K. Tian, Nanoscale, 2018, 10, 13857 DOI: 10.1039/C8NR04255A

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