Issue 39, 2013

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

Abstract

Metabolic chemical reporters of glycosylation allow for the visualization and identification of a variety of glycoconjugates by taking advantage of the promiscuity of carbohydrate metabolism. Here we describe the synthesis and characterization of metabolic chemical reporters bearing an N-propargyloxycarbamate (Poc) group that creates discrimination between glycosylation pathways.

Graphical abstract: N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

Supplementary files

Article information

Article type
Communication
Submitted
02 Nov 2012
Accepted
03 Dez 2012
First published
03 Dez 2012

Chem. Commun., 2013,49, 4328-4330

N-Propargyloxycarbamate monosaccharides as metabolic chemical reporters of carbohydrate salvage pathways and protein glycosylation

L. A. Bateman, B. W. Zaro, K. N. Chuh and M. R. Pratt, Chem. Commun., 2013, 49, 4328 DOI: 10.1039/C2CC37963E

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