Issue 28, 2024

Advances in block copolymer-phospholipid hybrid vesicles: from physical–chemical properties to applications

Abstract

Hybrid vesicles, made of lipids and amphiphilic block copolymers, have become increasingly popular thanks to their versatile properties that enable the construction of intricate membranes mimicking cellular structures. This tutorial review gives an overview over the different hybrid vesicle designs, and provides a detailed analysis of their properties, including their composition, membrane fluidity, membrane homogeneity, permeability, stability. The review puts emphasis on the application of these hybrid vesicles in bottom-up synthetic biology and aims to offer an overview of design guidelines, particularly focusing on composition, to eventually realize the intended applications of these hybrid vesicles.

Graphical abstract: Advances in block copolymer-phospholipid hybrid vesicles: from physical–chemical properties to applications

Article information

Article type
Review Article
Submitted
29 Feb 2024
Accepted
23 Jun 2024
First published
24 Jun 2024
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY-NC license

Chem. Sci., 2024,15, 10724-10744

Advances in block copolymer-phospholipid hybrid vesicles: from physical–chemical properties to applications

E. Brodszkij and B. Städler, Chem. Sci., 2024, 15, 10724 DOI: 10.1039/D4SC01444H

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